enzymology Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...

, a beta-ketoacyl-acyl-carrier-protein synthase I () is an

enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...

that

catalyzes Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...

the

chemical reaction A chemical reaction is a process that leads to the IUPAC nomenclature for organic transformations, chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the pos ...

:an acyl-acyl-carrier-protein + malonyl-acyl-carrier-protein

\rightleftharpoons

a 3-oxoacyl-acyl-carrier-protein + CO₂ + acyl-carrier-protein Thus, the two substrates of this enzyme are acyl-acyl-carrier-protein and malonyl-acyl-carrier-protein, whereas its 3

products Product may refer to: Business * Product (business), an item that serves as a solution to a specific consumer problem. * Product (project management), a deliverable or set of deliverables that contribute to a business solution Mathematics * Produ ...

are 3-oxoacyl-acyl-carrier-protein, CO₂, and acyl carrier protein. This enzyme participates in

fatty acid biosynthesis Fatty is a derogatory term for someone who is obese. It may refer also to: People * Mai Fatty, Gambian politician * Roscoe Arbuckle (1887–1933), American actor and comedian * Fatty Briody (1858–1903), American Major League Baseball player * ...

. This enzyme belongs to the family of

transferase A transferase is any one of a class of enzymes that catalyse the transfer of specific functional groups (e.g. a methyl or glycosyl group) from one molecule (called the donor) to another (called the acceptor). They are involved in hundreds of di ...

s, specifically those

acyltransferase Acyltransferase is a type of transferase enzyme that acts upon acyl groups. Examples include: * Glyceronephosphate O-acyltransferase * Lecithin-cholesterol acyltransferase *Long-chain-alcohol O-fatty-acyltransferase In enzymology, a long-chain- ...

s transferring groups other than aminoacyl groups.

Nomenclature

The

systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivial ...

of this enzyme class is acyl- cyl-carrier-proteinmalonyl- cyl-carrier-proteinC-acyltransferase (decarboxylating). Other names in common use include: * beta-ketoacyl-ACP synthase I, * beta-ketoacyl synthetase, * beta-ketoacyl-ACP synthetase, * beta-ketoacyl-acyl carrier protein synthetase, * beta-ketoacyl- cyl carrier proteinsynthase, * beta-ketoacylsynthase, * condensing enzyme (CE), * 3-ketoacyl-acyl carrier protein synthase, * fatty acid condensing enzyme, * acyl-malonyl(acyl-carrier-protein)-condensing enzyme, * acyl-malonyl acyl carrier protein-condensing enzyme, * beta-ketoacyl acyl carrier protein synthase, * 3-oxoacyl- cyl-carrier-proteinsynthase, * 3-oxoacyl:ACP synthase I, * KASI, * KAS I, * FabF1, and * FabB.

References

* * * * * * * Neidhardt, F.C. (Ed.), Escherichia coli and Salmonella: Cellular and Molecular Biology, 2nd ed., vol. 1, ASM Press, Washington, DC, 1996, p. 612-636. EC 2.3.1 Enzymes of known structure {{2.3-enzyme-stub