Bernhard Brenner is a scientist who, through his experiments, elucidated the repeated cycles of stretch and release of muscle fibers under isometric conditions. Because of this, these cycles were named as "''Brenner Cycles''".

Biography

Brenner was born in Stuttgart, capital of Baden-Württenberg state in Germany. He studied Medicine at the University of Tübingen between the years of 1969-1975. In 1980, Bernhard Brenner became associate researcher visitor at National Institute of Health (NIH) where he clarified that, when the muscle is in its relaxed state, the complex

tropomyosin Tropomyosin is a two-stranded alpha-helical, coiled coil protein found in actin-based cytoskeletons. Tropomyosin and the actin skeleton All organisms contain organelles that provide physical integrity to their cells. These type of organelles ar ...

- troponin does not block cross-bridge bounds to actin. Due to this revelation, the pathway of muscle contraction was decoded, and then he correlated a rate of force for muscle redevelopment under calcium regulation called ''K_TR'' to the number of cross-bridges turnover kinetics. Until 1985, Bernhard Brenner worked with other colleagues Richard Podolsky, Evan Eisenberg, Joseph Chalovich, Lois Greene, Mark Schoenberg, and Leepo Yu, and after this period, Bernhard Brenner returned to Germany and became professor and director of th
Institute for Molecular and Cell Physiology at Hannover Medical School
(MHH). Later in his career, he started to study mutations in cardiac myosin related to

hypertrophic cardiomyopathy Hypertrophic cardiomyopathy (HCM, or HOCM when obstructive) is a condition in which the heart becomes thickened without an obvious cause. The parts of the heart most commonly affected are the interventricular septum and the ventricles. This r ...

. He died in 2017, from cancer.

References

University of Tübingen alumni Scientists from Stuttgart Year of birth missing 2017 deaths German physiologists {{Germany-scientist-stub