Sir Bernard Katz, FRS (; 26 March 1911 – 20 April 2003) was a German-born

British British may refer to: Peoples, culture, and language * British people, nationals or natives of the United Kingdom, British Overseas Territories, and Crown Dependencies. ** Britishness, the British identity and common culture * British English, ...

physician and

biophysicist Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study Biology, biological phenomena. Biophysics covers all scales of biological organization, from Molecule, molecular to organismic ...

, noted for his work on

nerve A nerve is an enclosed, cable-like bundle of nerve fibers (called axons) in the peripheral nervous system. A nerve transmits electrical impulses. It is the basic unit of the peripheral nervous system. A nerve provides a common pathway for the e ...

physiology Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical ...

. He shared the

Nobel Prize in physiology or medicine The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, accord ...

in 1970 with

Julius Axelrod Julius Axelrod (May 30, 1912 – December 29, 2004) was an American biochemist. He won a share of the Nobel Prize in Physiology or Medicine in 1970 along with Bernard Katz and Ulf von Euler. The Nobel Committee honored him for his work on the re ...

and

Ulf von Euler Ulf Svante von Euler (7 February 1905 – 9 March 1983) was a Swedish physiologist and pharmacologist. He shared the Nobel Prize in Physiology or Medicine in 1970 for his work on neurotransmitters. Life Ulf Svante von Euler-Chelpin was born in S ...

. He was made a

Knight Bachelor The title of Knight Bachelor is the basic rank granted to a man who has been knighted by the monarch but not inducted as a member of one of the organised orders of chivalry; it is a part of the British honours system. Knights Bachelor are the ...

in 1969.

Life and career

Katz was born in

Leipzig Leipzig ( , ; Upper Saxon: ) is the most populous city in the German state of Saxony. Leipzig's population of 605,407 inhabitants (1.1 million in the larger urban zone) as of 2021 places the city as Germany's eighth most populous, as wel ...

, Germany, to a Jewish family originally from Russia, the son of Eugenie (Rabinowitz) and Max Katz, a fur merchant. He was educated at the Albert Gymnasium in that city from 1921 to 1929 and went on to study medicine at the

University of Leipzig Leipzig University (german: Universität Leipzig), in Leipzig in Saxony, Germany, is one of the world's oldest universities and the second-oldest university (by consecutive years of existence) in Germany. The university was founded on 2 Decemb ...

. He graduated in 1934 and fled to Britain in February 1935. Katz went to work at

University College London , mottoeng = Let all come who by merit deserve the most reward , established = , type = Public research university , endowment = £143 million (2020) , budget = ...

, initially under the tutelage of

Archibald Vivian Hill Archibald Vivian Hill (26 September 1886 – 3 June 1977), known as A. V. Hill, was a British physiologist, one of the founders of the diverse disciplines of biophysics and operations research. He shared the 1922 Nobel Prize in Physiology or Me ...

. He finished his PhD in 1938 and won a

Carnegie Fellowship The Carnegie Corporation of New York is a philanthropic fund established by Andrew Carnegie in 1911 to support education programs across the United States, and later the world. Carnegie Corporation has endowed or otherwise helped to establis ...

to study with

John Carew Eccles Sir John Carew Eccles (27 January 1903 – 2 May 1997) was an Australian neurophysiologist and philosopher who won the 1963 Nobel Prize in Physiology or Medicine for his work on the synapse. He shared the prize with Andrew Huxley and Alan Llo ...

at the Kanematsu Institute of

Sydney Medical School The University of Sydney School of Medicine, also known as Sydney Medical School (SMS) is the graduate medical school of the University of Sydney. Established in 1856, it is the first medical school in Australia. In 2018, Sydney Medical School j ...

. During this time, both he and Eccles gave research lectures at the

University of Sydney The University of Sydney (USYD), also known as Sydney University, or informally Sydney Uni, is a public research university located in Sydney, Australia. Founded in 1850, it is the oldest university in Australia and is one of the country's si ...

. He obtained British nationality in 1941 and joined the

Royal Australian Air Force "Through Adversity to the Stars" , colours = , colours_label = , march = , mascot = , anniversaries = RAAF Anniversary Commemoration ...

in 1942. He spent the war in the Pacific as a

radar Radar is a detection system that uses radio waves to determine the distance (''ranging''), angle, and radial velocity of objects relative to the site. It can be used to detect aircraft, ships, spacecraft, guided missiles, motor vehicles, w ...

officer and in 1946 was invited back to UCL as an assistant director by

Hill A hill is a landform that extends above the surrounding terrain. It often has a distinct Summit (topography), summit. Terminology The distinction between a hill and a mountain is unclear and largely subjective, but a hill is universally con ...

. For three years until 1949, the Katz family lived with

and his wife

Margaret Margaret is a female first name, derived via French () and Latin () from grc, μαργαρίτης () meaning "pearl". The Greek is borrowed from Persian. Margaret has been an English name since the 11th century, and remained popular througho ...

in the top flat of their house in

Highgate Highgate ( ) is a suburban area of north London at the northeastern corner of Hampstead Heath, north-northwest of Charing Cross. Highgate is one of the most expensive London suburbs in which to live. It has two active conservation organisati ...

. Back in England he also worked with the 1963 Nobel prize winners

Alan Hodgkin Sir Alan Lloyd Hodgkin (5 February 1914 – 20 December 1998) was an English physiologist and biophysicist who shared the 1963 Nobel Prize in Physiology or Medicine with Andrew Huxley and John Eccles. Early life and education Hodgkin was b ...

and

Andrew Huxley Sir Andrew Fielding Huxley (22 November 191730 May 2012) was an English physiologist and biophysicist. He was born into the prominent Huxley family. After leaving Westminster School in central London, he went to Trinity College, Cambridge on ...

. Katz was made a professor at UCL in 1952 and head of biophysics, he was elected a Fellow of the Royal Society (FRS) in 1952. He stayed as head of biophysics until 1978 when he became emeritus professor. Katz married Marguerite Penly in 1945. He died in London on 20 April 2003, at the age of 92. His son Jonathan is Public Orator of The

University of Oxford , mottoeng = The Lord is my light , established = , endowment = £6.1 billion (including colleges) (2019) , budget = £2.145 billion (2019–20) , chancellor ...

Research

His research uncovered fundamental properties of

synapse In the nervous system, a synapse is a structure that permits a neuron (or nerve cell) to pass an electrical or chemical signal to another neuron or to the target effector cell. Synapses are essential to the transmission of nervous impulses from ...

s, the junctions across which nerve cells signal to each other and to other types of cells. By the 1950s, he was studying the biochemistry and action of

acetylcholine Acetylcholine (ACh) is an organic chemical that functions in the brain and body of many types of animals (including humans) as a neurotransmitter. Its name is derived from its chemical structure: it is an ester of acetic acid and choline. Part ...

, a

signalling molecule In biology, cell signaling (cell signalling in British English) or cell communication is the ability of a cell to receive, process, and transmit signals with its environment and with itself. Cell signaling is a fundamental property of all cellula ...

found in synapses linking

motor neuron A motor neuron (or motoneuron or efferent neuron) is a neuron whose cell body is located in the motor cortex, brainstem or the spinal cord, and whose axon (fiber) projects to the spinal cord or outside of the spinal cord to directly or indirectl ...

s to

muscle Skeletal muscles (commonly referred to as muscles) are organs of the vertebrate muscular system and typically are attached by tendons to bones of a skeleton. The muscle cells of skeletal muscles are much longer than in the other types of muscl ...

s,The Release of Neural Transmitter Substances (The Sherrington Lectures X), Charles C Thomas Publisher, Springfield (Illinois) 1969, pp. 60 used to stimulate contraction. Katz won the Nobel for his discovery with

Paul Fatt Paul Fatt (13 January 1924 – 28 September 2014) was a British neuroscientist, who was a professor at University College London. With Bernard Katz, he developed the "quantal hypothesis" for neurotransmitter A neurotransmitter is a signa ...

that neurotransmitter release at synapses is "

quantal In physics, a quantum (plural quanta) is the minimum amount of any physical entity (physical property) involved in an interaction. The fundamental notion that a physical property can be "quantized" is referred to as "the hypothesis of quantizati ...

", meaning that at any particular synapse, the amount of neurotransmitter released is never less than a certain amount, and if more is always an integral number times this amount. Scientists now understand that this circumstance arises because, prior to their release into the synaptic gap, transmitter molecules reside in like-sized subcellular packages known as

synaptic vesicle In a neuron, synaptic vesicles (or neurotransmitter vesicles) store various neurotransmitters that are released at the synapse. The release is regulated by a voltage-dependent calcium channel. Vesicles are essential for propagating nerve impulse ...

s, released in a similar way to any other

vesicle Vesicle may refer to: ; In cellular biology or chemistry * Vesicle (biology and chemistry), a supramolecular assembly of lipid molecules, like a cell membrane * Synaptic vesicle ; In human embryology * Vesicle (embryology), bulge-like features o ...

during

exocytosis Exocytosis () is a form of active transport and bulk transport in which a cell transports molecules (e.g., neurotransmitters and proteins) out of the cell ('' exo-'' + ''cytosis''). As an active transport mechanism, exocytosis requires the use o ...

. Katz's work had immediate influence on the study of

organophosphate In organic chemistry, organophosphates (also known as phosphate esters, or OPEs) are a class of organophosphorus compounds with the general structure , a central phosphate molecule with alkyl or aromatic substituents. They can be considered a ...

s and

organochlorine An organochloride, organochlorine compound, chlorocarbon, or chlorinated hydrocarbon is an organic compound containing at least one covalent bond, covalently bonded atom of chlorine. The chloroalkane class (alkanes with one or more hydrogens subst ...

s, the basis of new post-war study for

nerve agent Nerve agents, sometimes also called nerve gases, are a class of organic chemicals that disrupt the mechanisms by which nerves transfer messages to organs. The disruption is caused by the blocking of acetylcholinesterase (AChE), an enzyme that ...

s and

pesticide Pesticides are substances that are meant to control pests. This includes herbicide, insecticide, nematicide, molluscicide, piscicide, avicide, rodenticide, bactericide, insect repellent, animal repellent, microbicide, fungicide, and lampri ...

s, as he determined that the complex enzyme cycle was easily disrupted.

References

External links

Sir Bernard Katz Biography
Nobel Foundation

* Sabbatini, R.M.E.

''Brain & Mind'', 2004.
Physiology Online, PhysiologyNews, Issue 52, Autumn 2003

König-Albert-Gymnasium Leipzig
* * {{DEFAULTSORT:Katz, Bernard 1911 births 2003 deaths Nobel laureates in Physiology or Medicine British Nobel laureates German Nobel laureates British neuroscientists German neuroscientists Jewish neuroscientists Jewish scientists Physicians from Leipzig Alumni of University College London Academics of University College London Recipients of the Copley Medal Knights Bachelor Fellows of the Royal Society Foreign associates of the National Academy of Sciences Jewish emigrants from Nazi Germany to the United Kingdom Electrophysiologists Neurophysiologists The Journal of Physiology editors

Life and career

Research

See also

References

External links