Benproperine ( INN) is a

cough suppressant Cold medicines are a group of medicinal, medications taken individually or in Combination drug, combination as a Symptomatic treatment, treatment for the symptoms of the common cold and similar conditions of the upper respiratory tract. The t ...

. It has been marketed in multiple countries in Central America and Europe, as the phosphate or pamoate salts in either tablet, dragée, or syrup form. Trade names include Blascorid in Italy and Sweden, Pectipront and Tussafug in Germany, and Pirexyl in Scandinavia. The recommended dosage for adults is 25 to 50 mg two to four times daily, and for children 25 mg once or twice daily. Adverse effects include dry mouth, dizziness, fatigue, and heartburn.

Synthesis

The base catalyzed ether formation between 2-Benzylphenol 8994-41-4(1) and

1,2-dichloropropane 1,2-Dichloropropane is an organic compound classified as a chlorocarbon. It is a colorless, flammable liquid with a sweet odor. it is obtained as a byproduct of the production of epichlorohydrin, which is produced on a large scale.Manfred Rossb ...

(2) gives 1-benzyl-2-(2-chloropropoxy)benzene 5909-36-0(3). Displacement of the remaining halogen with piperidine completes the synthesis of ''benproperine'' (4).

References

Antitussives 1-Piperidinyl compounds 2-Phenoxyethanamines Abandoned drugs {{respiratory-system-drug-stub