Bazinaprine (SR-95,191) is an experimental drug candidate. It is a
monoamine oxidase inhibitor
Monoamine oxidase inhibitors (MAOIs) are a class of drugs that inhibit the activity of one or both monoamine oxidase enzymes: monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B). They are best known as effective antidepressants, espe ...
(MAOI) which is believed to be useful for the treatment of
depression. The drug strongly inhibits type A
monoamine oxidase
Monoamine oxidases (MAO) () are a family of enzymes that catalyze the oxidation of monoamines, employing oxygen to clip off their amine group. They are found bound to the outer membrane of mitochondria in most cell types of the body. The first ...
, but only weakly inhibits type B. The effects of the drug are reversible
in vivo, but not
in vitro.
In studies, the chemical has been shown to not interact ''in vivo'' with other neurotransmitter or drug receptor sites.
See also
*
Reversible inhibitor of MAO-A
Monoamine oxidase inhibitors (MAOIs) are a class of drugs that inhibit the activity of one or both monoamine oxidase enzymes: monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B). They are best known as effective antidepressants, espe ...
(RIMA)
References
{{Monoamine metabolism modulators
Monoamine oxidase inhibitors
4-Morpholinyl compounds
Nitriles
Pyridazines