Barry M. Trost (born June 13, 1941, in
Philadelphia) is an American chemist who is the Job and Gertrud Tamaki Professor Emeritus in the School of Humanities and Sciences at
Stanford University
Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is consider ...
. The
Tsuji-Trost reaction and the
Trost ligand
The Trost ligand is a diphosphine used in the palladium- catalyzed Trost asymmetric allylic alkylation. Other C2-symmetric ligands derived from ''trans''-1,2-diaminocyclohexane (DACH) have been developed, such as the (''R'',''R'')-DACH- naphthy ...
are named after him. He is prominent for advancing the concept of
atom economy.
Early life and education
Trost was born in
Philadelphia, Pennsylvania on June 13, 1941. He studied at the
University of Pennsylvania and obtained his B.A. in 1962.
He then attended the
Massachusetts Institute of Technology for graduate school, where he worked with
Herbert O. House Herbert Otis House (December 5, 1929 – October 2, 2013) was an American organic chemist. House was born in Willoughby, Ohio, and obtained his Ph.D. in 1953 from the University of Illinois under the guidance of Reynold Fuson. Upon graduation, he ...
on
enolate anions, the
Mannich reaction, and the
Robinson annulation. Trost graduated with his Ph.D. in 1965.
Independent career
Trost moved to the
University of Wisconsin–Madison to begin his independent career, and was promoted to Professor of Chemistry in 1969, and the Vilas Research Professor in 1982.
In 1987, he moved to
Stanford University
Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is consider ...
as Professor of Chemistry, and was appointed the Job and Gertrud Tamaki Professor of Humanities and Sciences in 1990. He previously served as Chair of the Department of Chemistry.
, Trost has an
h-index of 161 according to
Google Scholar and of 140 (1040 documents) according to
Scopus.
Research
Trost's research focused on chemical synthesis.
In order to build complex target molecules from simple molecules, Trost developed new reactions and reagents, and utilized c
ascade reactions and tandem reactions.
Target molecules have potential applications as novel catalysts, as well as antibiotic and anti-tumor therapeutics.
References
Sources
Biographical Data at Trost's Home Page
External links
*
21st-century American chemists
Organic chemists
1941 births
Scientists from Philadelphia
University of Pennsylvania alumni
Living people
Members of the United States National Academy of Sciences
Massachusetts Institute of Technology alumni
Stanford University faculty
University of Wisconsin–Madison faculty
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