Bankole Johnson
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Bankole A. Johnson, DSc, MD, MPhil,
FRCPsych The Royal College of Psychiatrists is the main professional organisation of psychiatrists in the United Kingdom, and is responsible for representing psychiatrists, for psychiatric research and for providing public information about mental health ...
(born 5 November 1959) is a Nigerian
psychiatrist A psychiatrist is a physician who specializes in psychiatry, the branch of medicine devoted to the diagnosis, prevention, study, and treatment of mental disorders. Psychiatrists are physicians and evaluate patients to determine whether their sy ...
. He served as Alumni Professor and Chairman of the Department of Psychiatry and Neurobehavioral Sciences at the
University of Virginia The University of Virginia (UVA) is a Public university#United States, public research university in Charlottesville, Virginia. Founded in 1819 by Thomas Jefferson, the university is ranked among the top academic institutions in the United S ...
and is known for his research into addiction. Johnson's primary area of research expertise is the
psychopharmacology Psychopharmacology (from Greek grc, ψῡχή, psȳkhē, breath, life, soul, label=none; grc, φάρμακον, pharmakon, drug, label=none; and grc, -λογία, -logia, label=none) is the scientific study of the effects drugs have on m ...
of medications for treating
addictions Addiction is a neuropsychological disorder characterized by a persistent and intense urge to engage in certain behaviors, one of which is the usage of a drug, despite substantial harm and other negative consequences. Repetitive drug use of ...
, and he is well known in the field for his discovery that
topiramate Topiramate, sold under the brand name Topamax among others, is a carbonic anhydrase inhibitor medication used to treat epilepsy and prevent migraines. It has also been used in alcohol dependence. For epilepsy this includes treatment for gener ...
, a gamma-aminobutyric acid (GABA) facilitator and glutamate antagonist, is an effective treatment for alcoholism. Johnson also received national media attention for his appearance in the Home Box Office (
HBO Home Box Office (HBO) is an American premium television network, which is the flagship property of namesake parent subsidiary Home Box Office, Inc., itself a unit owned by Warner Bros. Discovery. The overall Home Box Office business unit is ba ...
) original documentary feature, "Addiction", which won a Governors Award, a special
Emmy Award The Emmy Awards, or Emmys, are an extensive range of awards for artistic and technical merit for the American and international television industry. A number of annual Emmy Award ceremonies are held throughout the calendar year, each with the ...
, from the
Academy of Television Arts and Sciences The Academy of Television Arts & Sciences (ATAS), also colloquially known as the Television Academy, is a professional honorary organization dedicated to the advancement of the television industry in the United States. It is a 501(c)(6) non-prof ...
. Johnson recently accepted an appointment to join the University of Maryland as the Chairman of Psychiatry and to lead a Brain Science Research Consortium in the neurosciences.


Biography

Johnson was born on 5 November 1959 in Nigeria. Johnson attended King's College in Lagos, Nigeria and received his diploma in 1975. He then went on to Davies' College in Sussex, England followed by the Institute Catholique de Paris in Paris, France. Johnson graduated from the
University of Glasgow , image = UofG Coat of Arms.png , image_size = 150px , caption = Coat of arms Flag , latin_name = Universitas Glasguensis , motto = la, Via, Veritas, Vita , ...
in Scotland in 1982 with a Medicinae Baccalaureum et Chirurgie Baccalaureum degree. He went on to train in psychiatry at the Royal London and Maudsley and Bethlem Royal Hospitals, and to train in research at the Institute of Psychiatry (
University of London The University of London (UoL; abbreviated as Lond or more rarely Londin in post-nominals) is a federal public research university located in London, England, United Kingdom. The university was established by royal charter in 1836 as a degree ...
). In 1991, Johnson graduated from the University of London with a Master of Philosophy degree in
neuropsychiatry Neuropsychiatry or Organic Psychiatry is a branch of medicine that deals with psychiatry as it relates to neurology, in an effort to understand and attribute behavior to the interaction of neurobiology and social psychology factors. Within neurop ...
. Johnson conducted his doctoral research at
Oxford University Oxford () is a city in England. It is the county town and only city of Oxfordshire. In 2020, its population was estimated at 151,584. It is north-west of London, south-east of Birmingham and north-east of Bristol. The city is home to the ...
and obtained a doctorate degree in medicine, Medicinae Doctorem, from the University of Glasgow in 1993. Most recently, in 2004, Johnson earned his Doctor of Science degree in medicine from the University of Glasgow – the highest degree that can be granted in science by a British university. Johnson joined the faculty at the University of Texas Health Science Center in Houston in 1993 and later became the Deputy chairman for Research and Chief of the Division of Alcohol and Drug Addiction in the Department of Psychiatry at the University of Texas Health Science Center in San Antonio in 1998. In 2001, Johnson received the Dan Anderson Research Award from the Hazelden Foundation for his "distinguished contribution as a researcher who has advanced the scientific knowledge of addiction recovery." In 2002, Johnson received the Distinguished Senior Scholar of Distinction Award from the
National Medical Association The National Medical Association (NMA) is the largest and oldest national organization representing African American physicians and their patients in the United States. The NMA is a 501(c)(3) national professional and scientific organization repr ...
. Johnson was inducted into the Texas Hall of Fame in 2003 for his contributions to science, mathematics, and technology. On 1 September 2004, Johnson accepted an appointment to serve as Alumni Professor and Chairman of the Department of Psychiatric Medicine at the University of Virginia. Johnson became a fellow of the
Royal College of Psychiatrists The Royal College of Psychiatrists is the main professional organisation of psychiatrists in the United Kingdom, and is responsible for representing psychiatrists, for psychiatric research and for providing public information about mental health ...
in 2007. In 2009 Johnson was named associate editor of the editorial board of ''The American Journal of Psychiatry'', and from 2010 to 2011 he served as field editor-in-chief of ''Frontiers in Psychiatry''. In 2019, Johnson received the R. Brinkley Smithers award from the American Association of Addiction Medicine.


Research

Johnson's research focus is on the
neuropsychopharmacology Neuropsychopharmacology, an interdisciplinary science related to psychopharmacology (study of effects of drugs on the mind) and fundamental neuroscience, is the study of the neural mechanisms that drugs act upon to influence behavior. It entails ...
of addiction. His work integrates the neuroscience and behavioural aspects of addiction medicine with the goal of formulating a more thorough understanding of the basis of drug-seeking behaviour and developing effective treatments. Central to his research is the role of and interaction between midbrain
monoamine Monoamine neurotransmitters are neurotransmitters and neuromodulators that contain one amino group connected to an aromatic ring by a two-carbon chain (such as -CH2-CH2-). Examples are dopamine, norepinephrine and serotonin. All monoamines are ...
systems with a focus on
serotonin Serotonin () or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter. Its biological function is complex and multifaceted, modulating mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vas ...
, gamma-aminobutyric acid (GABA)/
glutamate Glutamic acid (symbol Glu or E; the ionic form is known as glutamate) is an α-amino acid that is used by almost all living beings in the biosynthesis of proteins. It is a non-essential nutrient for humans, meaning that the human body can syn ...
and
dopamine Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells. It is an organic compound, organic chemical of the catecholamine and phenethylamine families. Dopamine const ...
. Johnson's
Journal of the American Medical Association ''The Journal of the American Medical Association'' (''JAMA'') is a peer-reviewed medical journal published 48 times a year by the American Medical Association. It publishes original research, reviews, and editorials covering all aspects of bio ...
(JAMA) paper, titled "Topiramate for treating alcohol dependence: a
randomized controlled trial A randomized controlled trial (or randomized control trial; RCT) is a form of scientific experiment used to control factors not under direct experimental control. Examples of RCTs are clinical trials that compare the effects of drugs, surgical te ...
" and published in 2007, gained national and international media attention. The 14-week US multi-site clinical trial involved 371 male and female alcoholics. Those patients taking topiramate had reduced heavy drinking and showed better results with lowering
cholesterol Cholesterol is any of a class of certain organic molecules called lipids. It is a sterol (or modified steroid), a type of lipid. Cholesterol is biosynthesized by all animal cells and is an essential structural component of animal cell mem ...
, body mass index, liver enzymes, and blood pressure than those taking the placebo. The study results were featured on Reuters, MSNBC, CBS, ABC, CNN, Fox News, USA Today, the Associated Press, and many other media outlets."Migraine pill helps curb drinking without detox: New approach called promising, but side effects still a problem, study finds" 9 October 2007. http://www.nbcnews.com/id/21209314 Johnson’s current research involves clinical trials and human laboratory studies, and includes
neuroimaging Neuroimaging is the use of quantitative (computational) techniques to study the structure and function of the central nervous system, developed as an objective way of scientifically studying the healthy human brain in a non-invasive manner. Incre ...
and
molecular genetics Molecular genetics is a sub-field of biology that addresses how differences in the structures or expression of DNA molecules manifests as variation among organisms. Molecular genetics often applies an "investigative approach" to determine the ...
. He now incorporates neuroimaging evaluations into his drug interaction studies to identify the site-specific effects of abused drugs and to evaluate the effectiveness of potential medications for the treatment of addiction. Current studies include a clinical trial aimed at determining the effectiveness of ondansetron, a serotonin-3 antagonist, for the treatment of subtypes of alcoholics, as well as a human laboratory project trying to elucidate the effects of
naltrexone Naltrexone, sold under the brand name Revia among others, is a medication primarily used to manage alcohol or opioid use disorder by reducing cravings and feelings of euphoria associated with substance use disorder. It has also been found t ...
and
acamprosate Acamprosate, sold under the brand name Campral, is a medication used along with counselling to treat alcohol use disorder. For label updates seFDA index page for NDA 021431/ref> Acamprosate is thought to stabilize chemical signaling in the brai ...
on
hepatic The liver is a major organ only found in vertebrates which performs many essential biological functions such as detoxification of the organism, and the synthesis of proteins and biochemicals necessary for digestion and growth. In humans, it i ...
and
renal The kidneys are two reddish-brown bean-shaped organs found in vertebrates. They are located on the left and right in the retroperitoneal space, and in adult humans are about in length. They receive blood from the paired renal arteries; blood ...
function in alcohol-dependent individuals.


Honors and awards

* Inductee, Texas Hall of Fame for Science, Mathematics and Technology, 2003 * Appointed to the National Advisory Council for NIH/NIDA, 2004 – 2007 * Member, Medications Development Subcommittee of NIDA's Advisory Council on Drug Abuse, 2004 – 2007 * Member, Extramural Advisory Board for NIH/NIAAA, 2004 – present * Member, Medications Development Scientific Advisory Board for NIH/NIDA, 2005 – 2009 * American Psychiatric Association Distinguished Psychiatrist Lecturer Award, 2006 (for outstanding achievement in the field of psychiatry as an educator, researcher, and clinician) * NIH Roadmap Consultant, 2006 – present * Listed in "Best Doctors in America", 2007, 2009–2010 * Fellow, Royal College of Psychiatrists, 2007 – present * Distinguished Fellow, American Psychiatric Association, 2008 – present * American Psychiatric Association, Solomon Carter Fuller Award, 2009 * Fellow, American College of Neuropsychopharmacology, 2010 – present * Jack Mendelson Award, NIAAA – 2013


References


External links

*University of Virginia: http://www.healthsystem.virginia.edu/internet/psychiatric/staffandfaculty/research.cfm?uva_id=bj4x&hideintro=1 *The Excelsior Program: http://www.medicine.virginia.edu/clinical/departments/psychiatry/patients/excelsior *HBO Addiction Film Series: "Addiction": http://www.hbo.com/addiction/thefilm/centerpiece/618_segment_7.html *''Frontiers in Psychiatry'': https://web.archive.org/web/20100211141806/http://frontiersin.org/psychiatry/psychiatry/missionstatement/ * University of Maryland: https://web.archive.org/web/20151001110541/http://somvweb.som.umaryland.edu/absolutenm/templates/?a=2446&z=41 {{DEFAULTSORT:Johnson, Bankole 1959 births Bipolar disorder researchers Nigerian psychiatrists Alumni of the University of Glasgow Alumni of the University of London Alumni of the University of Oxford University of Texas at Austin faculty University of Virginia School of Medicine faculty 21st-century science writers Living people Fellows of the Royal College of Psychiatrists Nigerian expatriate academics in the United States King's College, Lagos alumni