Bamipine (trade name Soventol) is a pharmaceutical drug acting as an H₁ antihistamine with anticholinergic properties. It is used as an

antipruritic Antipruritics, abirritants, or anti-itch drugs, are medications that inhibit the itching (Latin: ''pruritus'') often associated with sunburns, allergic reactions, eczema, psoriasis, chickenpox, fungal infections, insect bites and stings like those ...

ointment. No oral use is known.: Bamipine.

Adverse effects

Side effects are typical of an old (first-generation) antihistamine: tiredness in adults, agitation in children,

mydriasis Mydriasis is the dilation of the pupil, usually having a non-physiological cause, or sometimes a physiological pupillary response. Non-physiological causes of mydriasis include disease, trauma, or the use of certain types of drugs. Normally, as ...

(dilation of the pupils). These effects are rare when bamipine is applied topically as an ointment. Allergic and

hypersensitivity Hypersensitivity (also called hypersensitivity reaction or intolerance) refers to undesirable reactions produced by the normal immune system, including allergies and autoimmunity. They are usually referred to as an over-reaction of the immune s ...

reactions are also rare. Acute

eczema Dermatitis is inflammation of the Human skin, skin, typically characterized by itchiness, erythema, redness and a rash. In cases of short duration, there may be small blisters, while in long-term cases the skin may become lichenification, thick ...

can be worsened by bamipine ointment.

Contraindications and interactions

No clinically relevant contraindications or interactions with other drugs are known.

Pharmacology

Pharmacokinetics

When applied topically, the maximal effect is reached after 20 to 60 minutes and lasts up to 48 hours. Bamipine is not absorbed through intact skin in relevant doses.

References

{{Histaminergics Piperidines H1 receptor antagonists