Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), more popularly known as baboon syndrome because of its resemblance to the distinctive red
buttocks
The buttocks (singular: buttock) are two rounded portions of the exterior anatomy of most mammals, located on the posterior of the pelvic region. In humans, the buttocks are located between the lower back and the perineum. They are composed ...
displayed by female
baboons, is a systemic
contact dermatitis
Contact dermatitis is a type of acute or chronic inflammation of the skin caused by exposure to chemical or physical agents. Symptoms of contact dermatitis can include itchy or dry skin, a red rash, bumps, blisters, or swelling. These rashes are ...
characterized by well-demarcated patches of
erythema
Erythema (from the Greek , meaning red) is redness of the skin or mucous membranes, caused by hyperemia (increased blood flow) in superficial capillaries. It occurs with any skin injury, infection, or inflammation. Examples of erythema not asso ...
distributed symmetrically on the buttocks.
The cause of the syndrome may be drug-related, i.e. induced by systemic administration of hydroxyzine
penicillin,
iodinated radio contrast media
and others.
Symptoms and signs
The typical rash commonly appears on buttocks. This then resembles the colour of a baboon's
buttocks
The buttocks (singular: buttock) are two rounded portions of the exterior anatomy of most mammals, located on the posterior of the pelvic region. In humans, the buttocks are located between the lower back and the perineum. They are composed ...
. Other areas like upper inner thigh and
armpits
The axilla (also, armpit, underarm or oxter) is the area on the human body directly under the shoulder joint. It includes the axillary space, an anatomical space within the shoulder girdle between the arm and the thoracic cage, bounded superio ...
, may be affected by the rash. The rashes are red and well-defined. The presentation is typically symmetrical and not associated with systemic symptoms.
Cause
Diagnosis
Treatment
Treatment of symmetrical drug related intertriginous and flexural exanthema involves identifying and stopping the causative agent. Topical steroids can help to reduce the redness.
Epidemiology
Baboon syndrome affects both sexes equally, and can occur at any age, but seems to be more common in childhood than in adulthood.
See also
*
Airbag dermatitis
Airbag dermatitis (also known as an "airbag burn") is caused skin irritation and trauma secondary to the deployment of airbags.
See also
* Airbag
* Contact dermatitis
Contact dermatitis is a type of acute or chronic inflammation of the ski ...
*
List of cutaneous conditions
References
Contact dermatitis
Syndromes affecting the skin
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