BRN-3 is a group of related
transcription factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The fu ...
s in the
POU family
POU or pou may refer to:
People
* Pou (surname), a surname
* Chu Pou (303–350), Chinese general and politician
* Pou Temara (born 1948), New Zealand Māori academic
Codes
* POU, IATA airport code and FAA location identifier for Hudson Valley R ...
.
They are also known as class 4 POU domain
homeobox
A homeobox is a DNA sequence, around 180 base pairs long, that regulates large-scale anatomical features in the early stages of embryonic development. For instance, mutations in a homeobox may change large-scale anatomical features of the full- ...
proteins.
There are three BRN-3 proteins encoded by the following genes:
* BRN3A (
POU4F1
POU domain, class 4, transcription factor 1 (POU4F1) also known as brain-specific homeobox/POU domain protein 3A (BRN3A), homeobox/POU domain protein RDC-1 or Oct-T1 is a protein that in humans is encoded by the ''POU4F1'' gene.
BRN3A (POU4F1) is ...
, )
* BRN3B (
POU4F2
POU domain, class 4, transcription factor 2 is a protein that in humans is encoded by the ''POU4F2'' gene.
Function
POU4F2 is a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important ...
, )
* BRN3C (
POU4F3
POU domain, class 4, transcription factor 3 is a protein that in humans is encoded by the ''POU4F3'' gene. It's a member of BRN-3 group, also known as POU family class 4.
Nomenclature
DFNA15 refers to a type of nonsyndromic deafness
Nonsyndrom ...
, )
Nomenclature
The BRN or Brn prefix is an abbreviation for "brain"; the longer name is "Brain-specific homeobox". The name of the group may also be abbreviated as POU4, Pou4, POU IV, or POU-IV.
References
External links
*
Transcription factors
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