Cytoplasmic tyrosine-protein kinase BMX is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
that in humans is encoded by the ''BMX''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
Tyrosine kinase
A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to the tyrosine residues of specific proteins inside a cell. It functions as an "on" or "off" switch in many cellular functions.
Tyrosine kinases belong to a larger cla ...
s are either receptor molecules, which contain transmembrane and extracellular domains, or nonreceptor proteins, which are located intracellularly. One family of nonreceptor TKs includes the genes
TEC,
TXK,
ITK
Itk is a framework for building mega-widgets using the Incr Tcl
incr Tcl (commonly stylised as '' ncr Tcl/nowiki>'', and often abbreviated to ''itcl'') is a set of object-oriented extensions for the Tcl programming language. It is widely us ...
, and
BTK. All of these proteins are homologs of the ''
Drosophila
''Drosophila'' () is a genus of flies, belonging to the family Drosophilidae, whose members are often called "small fruit flies" or (less frequently) pomace flies, vinegar flies, or wine flies, a reference to the characteristic of many species ...
'' Src28 TK and contain an
SH3 and
SH2 domain upstream of the TK domain.
Interactions
BMX has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with:
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PAK1,
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PTK2,
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PTPN21
Tyrosine-protein phosphatase non-receptor type 21 is an enzyme that in humans is encoded by the ''PTPN21'' gene.
Function
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signal ...
and
*
RUFY1
RUN and FYVE domain-containing protein 1 is a protein that in humans is encoded by the ''RUFY1'' gene. It is named after the RUN and FYVE domains it contains.
Interactions
RUFY1 has been shown to interact
Advocates for Informed Choice, ...
.
References
Further reading
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External links
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Tyrosine kinases
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