BD1031 or (R)-2-
-(3,4-dichlorophenyl)ethyl
The hyphen-minus is the most commonly used type of hyphen, widely used in digital documents. It is the only character that looks like a minus sign or a dash in many character sets such as ASCII or on most keyboards, so it is also used as s ...
ctahydropyrrolo
,2-a
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yrazine is a selective
sigma receptor agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...
, with a reported
binding affinity of ''K''
i = 1 ± 0.2 nM for the
sigma-1 receptor and 80 times selectivity over the
sigma-2 receptor.
The enantiomer of BD1031 is known as
BD1018
BD1018 or (S)-2- -(3,4-dichlorophenyl)ethylctahydropyrrolo ,2-ayrazine is a selective sigma receptor ligand, with a reported binding affinity of ''K''i = 5 ± 0.7 nM for the sigma-1 receptor and approximately 10 times selectivity over the sigma-2 ...
.
Consistent with other reported
sigma receptor agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...
s, BD1031 increases the behavioural toxicity of cocaine in Swiss Webster mice.
See also
*
BD1008
References
{{Sigma receptor modulators
Sigma agonists