B53 or B-53 may refer to :
*
B53 nuclear bomb
The Mk/B53 was a high-yield bunker buster thermonuclear weapon developed by the United States during the Cold War. Deployed on Strategic Air Command bombers, the B53, with a yield of 9 megatons, was the most powerful weapon in the U.S. nuc ...
*
HLA-B53
HLA-B53 (B53) is an HLA- B serotype. The serotype identifies the more common HLA-B*53 gene products. The B53 sequence is identical to B35 but short sequence specifies a Bw4 rather than a Bw6 motif (as found in B35), indicating B53 is a recent ...
, an HLA-B serotype
*
Convair XB-53
The Convair XB-53 was a proposed jet-powered medium bomber aircraft, designed by Convair for the United States Army Air Forces. With a radical tailless, forward-swept wing design, the aircraft appeared futuristic; however, the project was ca ...
, an American aircraft
{{Letter-NumberCombDisambig