Asunaprevir (formerly BMS-650032, brand name in

Japan Japan ( ja, 日本, or , and formally , ''Nihonkoku'') is an island country in East Asia. It is situated in the northwest Pacific Ocean, and is bordered on the west by the Sea of Japan, while extending from the Sea of Okhotsk in the north ...

and

Russia Russia (, , ), or the Russian Federation, is a List of transcontinental countries, transcontinental country spanning Eastern Europe and North Asia, Northern Asia. It is the List of countries and dependencies by area, largest country in the ...

Sunvepra) is an experimental drug candidate for the treatment of

hepatitis C Hepatitis C is an infectious disease caused by the hepatitis C virus (HCV) that primarily affects the liver; it is a type of viral hepatitis. During the initial infection people often have mild or no symptoms. Occasionally a fever, dark urine, a ...

. It was undergoing

development Development or developing may refer to: Arts *Development hell, when a project is stuck in development *Filmmaking, development phase, including finance and budgeting *Development (music), the process thematic material is reshaped * Photograph ...

Bristol-Myers Squibb The Bristol Myers Squibb Company (BMS) is an American multinational pharmaceutical company. Headquartered in New York City, BMS is one of the world's largest pharmaceutical companies and consistently ranks on the ''Fortune'' 500 list of the lar ...

and has completed

Phase III clinical trials The phases of clinical research are the stages in which scientists conduct experiments with a health intervention to obtain sufficient evidence for a process considered effective as a medical treatment. For drug development, the clinical phases ...

in 2013. Asunaprevir is an inhibitor of the

hepatitis C virus The hepatitis C virus (HCV) is a small (55–65 nm in size), enveloped, positive-sense single-stranded RNA virus of the family ''Flaviviridae''. The hepatitis C virus is the cause of hepatitis C and some cancers such as liver cancer ( hepato ...

enzyme serine protease NS3. Asunaprevir is being tested in combination with

pegylated interferon Pegylated interferon (PEG-IFN) is a class of medication that includes three different drugs as of 2012: * Pegylated interferon-alpha-2a * Pegylated interferon-alpha-2b * Pegylated interferon-beta-1a In these formulations, Polyethylene glycol (PEG ...

and

ribavirin Ribavirin, also known as tribavirin, is an antiviral medication used to treat RSV infection, hepatitis C and some viral hemorrhagic fevers. For hepatitis C, it is used in combination with other medications such as simeprevir, sofosbuvir, pegin ...

, as well as in interferon-free regimens with other direct-acting antiviral agents including

daclatasvir Daclatasvir, sold under the brand name Daklinza, is an antiviral medication used in combination with other medications to treat hepatitis C (HCV). The other medications used in combination include sofosbuvir, ribavirin, and interferon, vary depe ...

.AASLD: Daclatasvir plus Asunaprevir Rapidly Suppresses HCV in Prior Null Responders
. Highleyman, L. HIVandHepatitis.com. 8 November 2011.

References

Carbamates Chloroarenes Cyclopropanes CYP2D6 inhibitors Experimental drugs Isoquinolines NS3/4A protease inhibitors Pyrrolidines Sulfonamides Tert-butyl compounds {{Antiinfective-drug-stub

See also

References