Arias-Stella Reaction in Endometrium (45966643982)

Arias-Stella reaction, also Arias-Stella phenomenon, is a

benign Malignancy () is the tendency of a medical condition to become progressively worse. Malignancy is most familiar as a characterization of cancer. A ''malignant'' tumor contrasts with a non-cancerous benign tumor, ''benign'' tumor in that a malign ...

change in the

endometrium The endometrium is the inner epithelial layer, along with its mucous membrane, of the mammalian uterus. It has a basal layer and a functional layer: the basal layer contains stem cells which regenerate the functional layer. The functional laye ...

associated with the presence of

chorionic tissue Chorionic villi are villi that sprout from the chorion to provide maximal contact area with maternal blood. They are an essential element in pregnancy from a histomorphologic perspective, and are, by definition, a product of conception. Branche ...

. Arias-Stella reaction is due to progesterone primarily.

Cytologically Cell biology (also cellular biology or cytology) is a branch of biology that studies the structure, function, and behavior of cells. All living organisms are made of cells. A cell is the basic unit of life that is responsible for the living and ...

, it looks like a

malignancy Malignancy () is the tendency of a medical condition to become progressively worse. Malignancy is most familiar as a characterization of cancer. A ''malignant'' tumor contrasts with a non-cancerous ''benign'' tumor in that a malignancy is not s ...

and, historically, it was diagnosed as

endometrial cancer Endometrial cancer is a cancer that arises from the endometrium (the lining of the uterus or womb). It is the result of the abnormal growth of cells that have the ability to invade or spread to other parts of the body. The first sign is most o ...

Significance

It is significant only because it can be misdiagnosed as a

cancer Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal b ...

. It may be seen in a completely normal

pregnancy Pregnancy is the time during which one or more offspring develops ( gestates) inside a woman's uterus (womb). A multiple pregnancy involves more than one offspring, such as with twins. Pregnancy usually occurs by sexual intercourse, but ca ...

Diagnosis

It is characterized by

nuclear Nuclear may refer to: Physics Relating to the nucleus of the atom: * Nuclear engineering *Nuclear physics *Nuclear power *Nuclear reactor *Nuclear weapon *Nuclear medicine *Radiation therapy *Nuclear warfare Mathematics *Nuclear space *Nuclear ...

enlargement and may also have any of the following: an irregular

nuclear membrane The nuclear envelope, also known as the nuclear membrane, is made up of two lipid bilayer membranes that in eukaryotic cells surround the nucleus, which encloses the genetic material. The nuclear envelope consists of two lipid bilayer membrane ...

, granular

chromatin Chromatin is a complex of DNA and protein found in eukaryotic cells. The primary function is to package long DNA molecules into more compact, denser structures. This prevents the strands from becoming tangled and also plays important roles in r ...

, centronuclear vacuolization, and pseudonuclear inclusions. Five subtypes are recognized: #Minimal atypia. #Early secretory pattern. #Secretory or hypersecretory pattern. #Regenerative, proliferative or nonsecretory pattern. #Monstrous cell pattern.

History

It was first described by

Javier Arias Stella Javier Arias Stella (August 2, 1924 – February 25, 2020) was a Peruvian pathologist, politician, diplomat, academic, and lecturer who variously served as Minister of Public Health of Peru (1963-1965, 1967-1968), Minister of Foreign Relations of ...

, a

Peruvian Peruvians ( es, peruanos) are the citizens of Peru. There were Andean and coastal ancient civilizations like Caral, which inhabited what is now Peruvian territory for several millennia before the Spanish conquest in the 16th century; Peruvian p ...

pathologist Pathology is the study of the causal, causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when us ...

, in 1954.

References

Bibliography

* Textbook of Obstetrics by D.C. Dutta Page no. 180. {{ISBN, 81-7381-142-3 Mammal female reproductive system

Significance

Diagnosis

History

See also

References

Bibliography