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Andrew Jeremy Wakefield (born September 3, 1956) is a British
anti-vaccine Vaccine hesitancy is a delay in acceptance, or refusal, of vaccines despite the availability of vaccine services and supporting evidence. The term covers refusals to vaccinate, delaying vaccines, accepting vaccines but remaining uncertain abou ...
activist, former physician, and discredited academic who was
struck off The General Medical Council (GMC) is a public body that maintains the official register of medical practitioners within the United Kingdom. Its chief responsibility is to "protect, promote and maintain the health and safety of the public" by ...
the medical register for his involvement in ''The Lancet'' MMR autism fraud, a 1998 study that falsely claimed a link between the measles, mumps, and rubella (MMR) vaccine and
autism The autism spectrum, often referred to as just autism or in the context of a professional diagnosis autism spectrum disorder (ASD) or autism spectrum condition (ASC), is a neurodevelopmental condition (or conditions) characterized by difficulti ...
. He has subsequently become known for
anti-vaccination Vaccine hesitancy is a delay in acceptance, or refusal, of vaccines despite the availability of vaccine services and supporting evidence. The term covers refusals to vaccinate, delaying vaccines, accepting vaccines but remaining uncertain abou ...
activism. Publicity around the 1998 study caused a sharp decline in vaccination uptake, leading to a number of outbreaks of measles around the world. He was a surgeon on the liver transplant programme at the
Royal Free Hospital The Royal Free Hospital (also known simply as the Royal Free) is a major teaching hospital in the Hampstead area of the London Borough of Camden. The hospital is part of the Royal Free London NHS Foundation Trust, which also runs services at Bar ...
in London and became senior lecturer and honorary consultant in experimental gastroenterology at the Royal Free and University College School of Medicine. He resigned from his positions there in 2001, "by mutual agreement", then moved to the United States. In 2004, Wakefield co-founded and began working at the Thoughtful House research center (now renamed Johnson Center for Child Health and Development) in Austin, Texas, serving as executive director there until February 2010, when he resigned in the wake of findings against him by the British General Medical Council. Wakefield published his 1998 paper on autism in the prestigious medical journal '' The Lancet'', claiming to have identified a novel form of
enterocolitis Enterocolitis is an inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon. It may be caused by various infections, with bacteria, viruses, fungi, parasites, or other causes. Common clinical man ...
linked to autism. However, other researchers were unable to reproduce his findings, and a 2004 investigation by ''
Sunday Times ''The Sunday Times'' is a British newspaper whose circulation makes it the largest in Britain's quality press market category. It was founded in 1821 as ''The New Observer''. It is published by Times Newspapers Ltd, a subsidiary of News UK, whi ...
'' reporter
Brian Deer Brian Deer is a British investigative reporter, best known for inquiries into the drug industry, medicine and social issues for ''The Sunday Times''. Deer's investigative nonfiction book, ''The Doctor Who Fooled the World,'' was published in Se ...
identified undisclosed financial
conflicts of interest A conflict of interest (COI) is a situation in which a person or organization is involved in multiple interests, financial or otherwise, and serving one interest could involve working against another. Typically, this relates to situations in ...
on Wakefield's part. Wakefield reportedly stood to earn up to $43 million per year selling test kits. Most of Wakefield's co-authors then withdrew their support for the study's interpretations, and the General Medical Council (GMC) conducted an inquiry into allegations of
misconduct Misconduct is wrongful, improper, or unlawful conduct motivated by premeditated or intentional purpose or by obstinate indifference to the consequences of one's acts. It is an act which is forbidden or a failure to do that which is required. Misc ...
against Wakefield and two former colleagues, focusing on Deer's findings. In 2010, the GMC found that Wakefield had been dishonest in his research, had acted against his patients' best interests and mistreated developmentally delayed children, and had "failed in his duties as a responsible consultant". ''The Lancet'' fully retracted Wakefield's 1998 publication on the basis of the GMC's findings, noting that elements of the manuscript had been falsified and that the journal had been "deceived" by Wakefield. Three months later, Wakefield was struck off the
UK medical register The General Medical Council (GMC) is a public body that maintains the official register of medical practitioners within the United Kingdom. Its chief responsibility is to "protect, promote and maintain the health and safety of the public" by ...
, in part for his deliberate falsification of research published in ''The Lancet'', and was barred from practising medicine in the UK. In a related legal decision, a British court held that " ere is now no respectable body of opinion which supports akefield'shypothesis, that MMR vaccine and autism/enterocolitis are causally linked". Wakefield has continued to defend his research and conclusions, saying there was no fraud, hoax or
profit motive In economics, the profit motive is the motivation of firms that operate so as to maximize their profits. Mainstream microeconomic theory posits that the ultimate goal of a business is "to make money" - not in the sense of increasing the firm's ...
. In 2016, Wakefield directed the anti-vaccination film '' Vaxxed: From Cover-Up to Catastrophe''.


Early life and education

Wakefield was born in 1956; his father was a neurologist and his mother was a general practitioner. After leaving the independent
King Edward's School, Bath King Edward's School (KES), Bath, Somerset, England is an independent co-educational day school providing education for 1,016 pupils aged 3 to 18. The school is a member of The Headmasters' and Headmistresses' Conference. The school was establis ...
, Wakefield studied medicine at St Mary's Hospital Medical School (now Imperial College School of Medicine), fully qualifying in 1981. Wakefield became a fellow of the
Royal College of Surgeons The Royal College of Surgeons is an ancient college (a form of corporation) established in England to regulate the activity of surgeons. Derivative organisations survive in many present and former members of the Commonwealth. These organisations a ...
in 1985.


Career

At the University of Toronto from 1986 to 1989, he was a member of a team that studied tissue rejection problems with
small intestine The small intestine or small bowel is an organ in the gastrointestinal tract where most of the absorption of nutrients from food takes place. It lies between the stomach and large intestine, and receives bile and pancreatic juice through the ...
transplantation, using animal models. He continued his studies of small intestine transplantation under a Wellcome Trust travelling fellowship at University of Toronto in Canada.


Claims of measles virus–Crohn's disease link

Back in the UK, he worked on the liver transplant programme at the
Royal Free Hospital The Royal Free Hospital (also known simply as the Royal Free) is a major teaching hospital in the Hampstead area of the London Borough of Camden. The hospital is part of the Royal Free London NHS Foundation Trust, which also runs services at Bar ...
in London. In 1993, Wakefield attracted professional attention when he published reports in which he concluded that measles virus might cause
Crohn's disease Crohn's disease is a type of inflammatory bowel disease (IBD) that may affect any segment of the gastrointestinal tract. Symptoms often include abdominal pain, diarrhea (which may be bloody if inflammation is severe), fever, abdominal distension, ...
; and two years later he published a paper in '' The Lancet'' proposing a link between the
measles vaccine Measles vaccine protects against becoming infected with measles. Nearly all of those who do not develop immunity after a single dose develop it after a second dose. When rate of vaccination within a population is greater than 92%, outbreaks of m ...
and Crohn's disease. Subsequent research failed to confirm this hypothesis, with a group of experts in Britain reviewing a number of peer-reviewed studies in 1998 and concluding that the measles virus did not cause Crohn's disease, and neither did the MMR vaccine. Later, in 1995, while conducting research into Crohn's disease, he was approached by Rosemary Kessick, the parent of a child with autism, who was seeking help with her son's bowel problems and autism; Kessick ran a group called Allergy Induced Autism. In 1996, Wakefield turned his attention to researching possible connections between the MMR vaccine and autism. At the time of his MMR research study, Wakefield was senior lecturer and honorary consultant in experimental gastroenterology at the Royal Free Hospital School of Medicine (from 2008,
UCL Medical School UCL Medical School is the medical school of University College London (UCL) and is located in London, United Kingdom. The School provides a wide range of undergraduate and postgraduate medical education programmes and also has a medical educatio ...
). He resigned in 2001, by "mutual agreement and was made a fellow of the Royal College of Pathologists", and moved to the US in 2001 (or 2004, by another account). He was reportedly asked to leave the Royal Free Hospital after refusing a request to validate his 1998 ''Lancet'' paper with a controlled study. Wakefield subsequently helped establish and served as the executive director of Thoughtful House Center for Children, which studies autism in Austin, Texas, where, according to ''The Times'', he "continued to promote the theory of a link between the MMR vaccine and autism, despite admitting it was 'not proved'." He resigned from Thoughtful House in February 2010, after the British General Medical Council found that he had been "dishonest and irresponsible" in conducting his earlier autism research in England. ''The Times'' reported in May 2010 that he was a medical advisor for Visceral, a UK charity that "researches bowel disease and developmental disorders". Wakefield is barred from practising as a physician in the UK, and is not licensed in the US. He lives in the US where he has a following, including the anti-vaccinationist
Jenny McCarthy Jennifer McCarthy Wahlberg (' Jennifer Ann McCarthy; born November 1, 1972) is an American actress, model, and television personality. She began her career in 1993 as a nude model for ''Playboy'' magazine and was later named their Playmate of ...
, who wrote the foreword for Wakefield's autobiography, ''Callous Disregard''. She has a son with autism-like symptoms that she believes were caused by the MMR vaccine. According to Deer, , Wakefield lives near Austin with his family. Wakefield has set up the non-profit Strategic Autism Initiative to commission studies into the condition, and is currently listed as a director of a company called Medical Interventions for Autism and another called the Autism Media Channel.


''The Lancet'' fraud

On 28 February 1998, Wakefield was the lead author of a study of twelve children with autism that was published in ''The Lancet''. The study proposed a new syndrome called autistic enterocolitis, and raised the possibility of a link between a novel form of bowel disease, autism, and the MMR vaccine. The authors said that the parents of eight of the twelve children linked what were described as "behavioural symptoms" with MMR, and reported that the onset of these symptoms began within two weeks of MMR vaccination. These possible triggers were reported as MMR in eight cases, and measles infection in one. The paper was instantly controversial, leading to widespread publicity in the UK and the convening of a special panel of the UK's Medical Research Council the following month. One 2005 study in Japan found that there was no causal relationship between the MMR vaccine and autism in groups of children given the triple MMR vaccine and children who received individual measles, mumps and rubella vaccinations. In Japan, the MMR vaccine had been replaced with individual vaccinations in 1993. Although the paper said that no causal connection had been proven, before it was published, Wakefield made statements at a press conference and in a video news release issued by the hospital, calling for suspension of the triple MMR vaccine until more research could be done. This was later criticized as ' science by press conference'. According to BBC News, it was this press conference, rather than the paper in ''The Lancet'', that fuelled the MMR vaccination scare. The BBC report said he told journalists: "it was a 'moral issue' and he could no longer support the continued use of the three-in-one jab for measles, mumps and rubella. 'Urgent further research is needed to determine whether MMR may give rise to this complication in a small number of people,' Wakefield said at the time." He said, "If you give three viruses together, three live viruses, then you potentially increase the risk of an adverse event occurring, particularly when one of those viruses influences the immune system in the way that measles does." He suggested parents should opt for single vaccinations against measles, mumps and rubella, separated by gaps of one year. ''
60 Minutes ''60 Minutes'' is an American television news magazine broadcast on the CBS television network. Debuting in 1968, the program was created by Don Hewitt and Bill Leonard, who chose to set it apart from other news programs by using a unique sty ...
'' interviewed him in November 2000, and he repeated these claims to the U.S. audience, providing a new focus for the nascent anti-vaccination movement in the U.S., which had been primarily concerned about
thiomersal Thiomersal ( INN), or thimerosal ( USAN, JAN), is an organomercury compound. It is a well-established antiseptic and antifungal agent. The pharmaceutical corporation Eli Lilly and Company gave thiomersal the trade name Merthiolate. It has been ...
in vaccines. In December 2001, Wakefield resigned from the Royal Free Hospital, saying, "I have been asked to go because my research results are unpopular." The medical school said that he had left "by mutual agreement". In February 2002, Wakefield stated: "What precipitated this crisis was the removal of the single vaccine, the removal of choice, and that is what has caused the furore—because the doctors, the gurus, are treating the public as though they are some kind of moronic mass who cannot make an informed decision for themselves."


Aftermath of initial controversy

Wakefield continued to conduct clinical research in the United States after leaving the Royal Free Hospital in December 2001. He joined a controversial American researcher,
Jeff Bradstreet James Jeffrey "Jeff" Bradstreet (July 6, 1954 – June 19, 2015), was an American doctor, alternative medicine practitioner, and a former preacher who ran the International Child Development Resource Center in Melbourne, Florida, a medica ...
, at the International Child Development Resource Center, to conduct further studies on the possible relationship between the MMR vaccine and autism. In 2004, Wakefield began working at the Thoughtful House research center in Austin, Texas. Wakefield served as executive director of Thoughtful House until February 2010, when he resigned in the wake of findings against him by the British General Medical Council. In February 2004, the controversy resurfaced when Wakefield was accused of a conflict of interest. In '' The Sunday Times'', Brian Deer reported that some of the parents of the 12 children in the study in ''The Lancet'' were recruited via a UK lawyer preparing a lawsuit against MMR manufacturers, and that the Royal Free Hospital had received £55,000 from the UK's Legal Aid Board (now the
Legal Services Commission The Legal Services Commission (LSC) was an executive non-departmental public body of the Ministry of Justice which was responsible for the operational administration of legal aid in England and Wales between 2000 and 2013. Overview The LSC was re ...
) to pay for the research. Previously, in October 2003, the board had cut off public funding for the litigation against MMR manufacturers. Following an investigation of the allegations in ''The Sunday Times'' by the UK General Medical Council, Wakefield was charged with serious professional misconduct, including dishonesty. In December 2006, Deer, writing in ''The Sunday Times'', further reported that in addition to the money they donated to the Royal Free Hospital, the lawyers responsible for the MMR lawsuit had paid Wakefield personally more than £400,000, which he had not previously disclosed. Twenty-four hours before the 2004 ''Sunday Times'' report by Deer, ''The Lancet''s editor Richard Horton responded to the investigation in a public statement, describing Wakefield's research as "fatally flawed" and said he believed the paper would have been rejected as biased if the peer reviewers had been aware of Wakefield's conflict of interest. Ten of Wakefield's twelve co-authors of the paper in ''The Lancet'' later published a retraction of an interpretation. The section of the paper retracted read as follows: The retraction stated:


''Wakefield v Channel 4 Television and Others''

In November 2004,
Channel 4 Channel 4 is a British free-to-air public broadcast television network operated by the state-owned Channel Four Television Corporation. It began its transmission on 2 November 1982 and was established to provide a fourth television service in ...
broadcast a one-hour '' Dispatches'' investigation by reporter Brian Deer; the ''Toronto Star'' said Deer had "produced documentary evidence that Wakefield applied for a patent on a single-jab measles vaccine before his campaign against the MMR vaccine, raising questions about his motives". In addition to Wakefield's unpublished initial patent submission, Deer released a copy of the published patent application. At page 1, the first paragraph of this stated: Before describing the research in Wakefield's 1998 paper in ''The Lancet'', at the same page this patent explicitly states that the use of the MMR vaccine causes autism: According to Deer, a letter from Wakefield's lawyers to him dated 31 January 2005 said: "Dr Wakefield did not plan a rival vaccine." In the ''Dispatches'' programme, Deer also revealed that Nicholas Chadwick, a researcher working under Wakefield's supervision in the Royal Free medical school, had failed to find measles virus in the children reported on in ''The Lancet''. In January 2005, Wakefield initiated libel proceedings against Channel 4, the independent production company Twenty Twenty and Brian Deer, ''The Sunday Times'', and against Deer personally along with his website briandeer.com in the case ''Wakefield v Channel Four Television and Others''
006 Alec Trevelyan (006) is a fictional character and the main antagonist in the 1995 James Bond film ''GoldenEye'', the first film to feature actor Pierce Brosnan as Bond. Trevelyan is portrayed by actor Sean Bean. The likeness of Bean as Alec Tre ...
EWHC 3289 (QB);
007 The ''James Bond'' series focuses on a fictional British Secret Service agent created in 1953 by writer Ian Fleming, who featured him in twelve novels and two short-story collections. Since Fleming's death in 1964, eight other authors have ...
94 BMLR 1. Within weeks of issuing his claims, however, Wakefield sought to have the action frozen until after the conclusion of General Medical Council proceedings against him. Channel 4 and Deer sought a High Court order compelling Wakefield to continue with his action, or discontinue it. After a hearing on 27 and 28 October 2005, Justice David Eady ruled against a
stay of proceedings Stay may refer to: Places * Stay, Kentucky, an unincorporated community in the US Law * Stay of execution, a ruling to temporarily suspend the enforcement of a court judgment * Stay of proceedings, a ruling halting further legal process in a t ...
: The judgment identified Channel 4's "very lengthy extracts" summarizing Deer's allegations against Wakefield: :(i) akefieldspread fear that the MMR vaccine might lead to autism, even though he knew that his own laboratory had carried out tests whose results dramatically contradicted his claims in that the measles virus had not been found in a single one of the children concerned in his study and he knew or ought to have known that there was absolutely no basis at all for his belief that the MMR should be broken up into single vaccines. :(ii) In spreading such fear, acted dishonestly and for mercenary motives in that, although he improperly failed to disclose the fact, he planned a rival vaccine and products (such as a diagnostic kit based on his theory) that could have made his fortune :(iii) Gravely abused the children under his care by unethically carrying out extensive invasive procedures (on occasions requiring three people to hold a child down), thereby driving nurses to leave and causing his medical colleagues serious concern and unhappiness :(iv) Improperly and/or dishonestly failed to disclose to his colleagues and to the public that his research on autistic children had begun with a contract with solicitors who were trying to sue the manufacturers of the MMR vaccine :(v) Improperly or dishonestly lent his reputation to the International Child Development Resource Centre, which promoted to very vulnerable parents expensive products for whose efficacy (as he knew or should have known) there was no scientific evidence Eady's ruling states that, "The views or conclusions of the GMC disciplinary body would not, so far as I can tell, be relevant or admissible", that Channel 4's allegations "go to undermine fundamentally the Claimant's professional integrity and honesty", and that, "It cannot seriously be suggested that priority should be given to GMC proceedings for the resolution of issues." In December 2006, Deer released records obtained from the Legal Services Commission, showing that it had paid £435,643 in undisclosed fees to Wakefield for the purpose of building a case against the MMR vaccine. Those payments, ''The Sunday Times'' reported, had begun two years before publication of Wakefield's paper in ''The Lancet''. Within days of Deer's report, Wakefield dropped all his libel actions and was ordered to pay all defendants' legal costs.


Other concerns

Wakefield's data was also questioned; a former graduate student, who appeared in Deer's programme, later testified that Wakefield ignored laboratory data that conflicted with his hypothesis. An independent investigation of a collaborating laboratory questioned the accuracy of the data underpinning Wakefield's claims. In June 2005, the
BBC #REDIRECT BBC Here i going to introduce about the best teacher of my life b BALAJI sir. He is the precious gift that I got befor 2yrs . How has helped and thought all the concept and made my success in the 10th board exam. ...
programme '' Horizon'' reported on an unnamed and unpublished study of blood samples from a group of 100 autistic children and 200 children without autism. They reported finding 99% of the samples contained no trace of the measles virus, and the samples that did contain the virus were just as likely to be from non-autistic children, i.e., only three samples contained the measles virus, one from an autistic child and two from a typically developing child. The study's authors found no evidence of any link between MMR and autism. The Institute of Medicine (IOM) of the United States National Academy of Sciences, along with the
CDC The Centers for Disease Control and Prevention (CDC) is the national public health agency of the United States. It is a United States federal agency, under the Department of Health and Human Services, and is headquartered in Atlanta, Georg ...
and the UK National Health Service, have found no link between vaccines and autism. Reviews in the medical literature have also found no link between the MMR vaccine and autism or with bowel disease, which Wakefield called " autistic enterocolitis".


General Medical Council hearings

Between July 2007 and May 2010, a 217-day "fitness to practise" hearing of the UK General Medical Council examined charges of
professional misconduct Professional ethics encompass the personal and corporate standards of behavior expected of professionals. The word professionalism originally applied to vows of a religious order. By no later than the year 1675, the term had seen secular applic ...
against Wakefield and two colleagues involved in the paper in ''The Lancet''. The charges included that he: * "Was being paid to conduct the study by solicitors representing parents who believed their children had been harmed by MMR". * Ordered investigations "without the requisite paediatric qualifications" including colonoscopies, colon biopsies and lumbar punctures ("spinal taps") on his research subjects without the approval of his department's ethics board and contrary to the children's clinical interests, when these diagnostic tests were not indicated by the children's symptoms or medical history. * "Act d'dishonestly and irresponsibly' in failing to disclose ... how patients were recruited for the study" as well as in his descriptions in the Lancet papers and in questions after the paper published, about what ailments the children had, and when those ailments were observed relative to their getting vaccinated. * "Conduct dthe study on a basis not approved by the hospital's ethics committee." * Purchased blood samples—for £5 each—from children present at his son's birthday party, which Wakefield joked about in a later presentation. * " owed callous disregard for any distress or pain the children might suffer" Wakefield denied the charges; on 28 January 2010, the GMC ruled against Wakefield on all issues, stating that he had "failed in his duties as a responsible consultant", acted against the interests of his patients, and "dishonestly and irresponsibly" in his controversial research. On 24 May 2010, he was struck off the United Kingdom medical register. It was the harshest sanction that the GMC could impose, and effectively ended his career as a physician. In announcing the ruling, the GMC said that Wakefield had "brought the medical profession into disrepute", and no sanction short of erasing his name from the register was appropriate for the "serious and wide-ranging findings" of misconduct. On the same day, Wakefield's autobiography, ''Callous Disregard'' was published, using the same words as one of the charges against him ("he showed callous disregard for any distress or pain the children might suffer"). Wakefield argued that he had been unfairly treated by the medical and scientific establishment.


Fraud and conflict of interest allegations

In February 2009, ''The Sunday Times'' reported that a further investigation by the newspaper had revealed that Wakefield "changed and misreported results in his research, creating the appearance of a possible link with autism", citing evidence obtained by the newspaper from medical records and interviews with witnesses, and supported by evidence presented to the GMC. In April 2010, Deer expanded on laboratory aspects of his findings in a report in the ''
BMJ ''The BMJ'' is a weekly peer-reviewed medical trade journal, published by the trade union the British Medical Association (BMA). ''The BMJ'' has editorial freedom from the BMA. It is one of the world's oldest general medical journals. Origina ...
'', recounting how normal clinical
histopathology Histopathology (compound of three Greek words: ''histos'' "tissue", πάθος ''pathos'' "suffering", and -λογία ''-logia'' "study of") refers to the microscopic examination of tissue in order to study the manifestations of disease. Spec ...
results (obtained from the Royal Free hospital) had been subjected to wholesale changes, from normal to abnormal, in the medical school and published in ''The Lancet''. On 2 January 2011, Deer provided two tables comparing the data on the twelve children, showing the original hospital data and the data with the wholesale changes as used in the 1998 ''The Lancet'' article. On 5 January 2011, ''BMJ'' published an article by Brian Deer entitled "How the case against the MMR vaccine was fixed". Deer said that, based on examination of the medical records of the 12 children in the original study, his research had found: In an accompanying editorial, ''BMJ'' editors said: The ''
British Medical Journal ''The BMJ'' is a weekly peer-reviewed medical trade journal, published by the trade union the British Medical Association (BMA). ''The BMJ'' has editorial freedom from the BMA. It is one of the world's oldest general medical journals. Origina ...
'' editorial concluded that Wakefield's paper was an "elaborate fraud". In a ''BMJ'' follow-up article on 11 January 2011, Deer stated that Wakefield had planned to capitalize on the MMR vaccination scare provoked by his paper. He said that based upon documents he had obtained under Freedom of information legislation, Wakefield—in partnership with the father of one of the boys in the study—had planned to launch a venture on the back of an MMR vaccination scare that would profit from new medical tests and "litigation driven testing". '' The Washington Post'' reported that Deer said that Wakefield predicted he "could make more than $43 million a year from diagnostic kits" for the new condition, autistic enterocolitis. According to Deer's report in ''BMJ'', the ventures, Immunospecifics Biotechnologies Ltd and Carmel Healthcare Ltd—named after Wakefield's wife—failed after Wakefield's superiors at University College London's medical school gave him a two-page letter that said:
WebMD WebMD is an American corporation known primarily as an online publisher of news and information pertaining to human health and well-being. The site includes information pertaining to drugs. It is one of the top healthcare websites. It was fo ...
reported on Deer's ''BMJ'' report, saying that the $43 million predicted yearly profits would come from marketing kits for "diagnosing patients with autism" and that "the initial market for the diagnostic will be litigation-driven testing of patients with AE utistic enterocolitis, an unproven condition concocted by Wakefieldfrom both the UK and the US". According to WebMD, the ''BMJ'' article also claimed that Carmel Healthcare Ltd. would succeed in marketing products and developing a replacement vaccine if "public confidence in the MMR vaccine was damaged". In October 2012, research published in PNAS, the Proceedings of the National Academy of Sciences, identified Wakefield's 1998 paper as the most cited retracted scientific paper, with 758 citations, and gave the "reason for retraction" as "fraud".


Journal retractions

On 2 February 2010, ''The Lancet'' formally retracted Wakefield's 1998 paper. The retraction states: "The claims in the original paper that children were 'consecutively referred' and that investigations were 'approved' by the local ethics committee have been proven to be false." The following day, the editor of a specialist journal, ''
NeuroToxicology Neurotoxins are toxins that are destructive to nervous tissue, nerve tissue (causing neurotoxicity). Neurotoxins are an extensive class of exogenous chemical neurological insult (medical), insultsSpencer 2000 that can adversely affect function ...
'', withdrew another Wakefield paper that was in press. The article, which concerned research on monkeys, had already been published online and sought to implicate vaccines in autism. In May 2010, ''
The American Journal of Gastroenterology ''The American Journal of Gastroenterology'' is a peer reviewed medical journal owned by the American College of Gastroenterology. It has been published by Lippincott Williams & Wilkins since 2019 and was previously published by Nature Research ...
'' retracted a paper of Wakefield's that used data from the 12 patients of the article in ''The Lancet''. On 5 January 2011, ''British Medical Journal'' editors recommended that Wakefield's other publications should be scrutinized and retracted if need be.


Wakefield response

As of January 2011, Wakefield continued to maintain his innocence. In a press release, he stated, In an Internet radio interview, Wakefield said the ''BMJ'' series "was utter nonsense" and denied "that he used the cases of the 12 children in his study to promote his business venture". Deer has filed financial disclosure forms and rejects Wakefield's claim that he is funded by the pharmaceutical industry. According to
CNN CNN (Cable News Network) is a multinational cable news channel headquartered in Atlanta, Georgia, U.S. Founded in 1980 by American media proprietor Ted Turner and Reese Schonfeld as a 24-hour cable news channel, and presently owned by t ...
, Wakefield said the patent he held was for "an 'over-the-counter nutritional supplement' that boosts the immune system". WebMD reported that Wakefield said he was the victim of "a ruthless, pragmatic attempt to crush any attempt to investigate valid vaccine safety concerns". Wakefield says that Deer is a "hit man who was brought in to take imdown" and that other scientists have simply taken Deer at his word. While on ''
Anderson Cooper 360° ''Anderson Cooper 360°'' (commonly shortened to either ''AC-360'' or ''360'') is an American television news show on CNN and CNN International, hosted by CNN journalist and news anchor Anderson Cooper. Since May 20, 2019, ''360°'' has been br ...
'', he said that he had not read the ''BMJ'' articles yet, but he denied their validity and denied that Deer had interviewed the families of the children in the study. He also urged viewers to read his book, ''Callous Disregard'', which he said would explain why he was being targeted, to which
Anderson Cooper Anderson Hays Cooper (born June 3, 1967) is an American broadcast journalist and political commentator from the Vanderbilt family. He is the primary anchor of the CNN news broadcast show ''Anderson Cooper 360°''. In addition to his duties at C ...
replied: "But sir, if you're lying, then your book is also a lie. If your study is a lie, your book is a lie." Wakefield later implied that there is a
conspiracy A conspiracy, also known as a plot, is a secret plan or agreement between persons (called conspirers or conspirators) for an unlawful or harmful purpose, such as murder or treason, especially with political motivation, while keeping their agr ...
by public health officials and pharmaceutical companies to discredit him, including suggesting they pay bloggers to post rumours about him on websites or that they artificially inflated reports of deaths from measles.


Deer counter-response

Deer responded to Wakefield's charge by challenging Wakefield to sue him: Deer mentioned that all of Wakefield's previous libel actions had been dismissed or withdrawn. In January 2012, Wakefield filed a defamation lawsuit in Texas state court against Deer, Fiona Godlee, and the ''BMJ'' for false accusations of fraud, seeking a jury trial in
Travis County Travis County is located in south central Texas. As of the 2020 census, the population was 1,290,188. It is the fifth-most populous county in Texas. Its county seat is Austin, the capital of Texas. The county was established in 1840 and is n ...
. The filing identified Wakefield as a resident of Austin, and cited the " Texas Long-Arm Statute" as justification for initiating the proceeding in Texas. The ''BMJ'' responded that it stood by its reports and would "defend the claim vigorously". In August 2012 District Court Judge Amy Meachum dismissed Wakefield's suit for lack of jurisdiction. Her ruling was upheld on appeal in September 2014 and Wakefield was ordered to pay all parties' costs. On 5 April 2011, Deer was named the UK's specialist journalist of the year in the
British Press Awards The Press Awards, formerly the British Press Awards, is an annual ceremony that celebrates the best of British journalism. History Established in 1962 by '' The People'' and '' World's Press News'', the first award ceremony for the then-named ...
, organised by the Society of Editors. The judges said that Deer's investigation of Wakefield was a "tremendous righting of a wrong".


Epidemics, effects, and reception

Physicians, medical journals, and editors have made statements tying Wakefield's fraudulent actions to various epidemics and deaths. Michael J. Smith, a professor of pediatrics at the University of Louisville, an "infectious diseases expert who has studied the autism controversy's effect on immunization rates", said, "Clearly, the results of this akefieldstudy have had repercussions." Wakefield's study and his claim that the MMR vaccine might cause autism led to a decline in vaccination rates in the United States, the United Kingdom, and Ireland, and a corresponding rise in measles and
mumps MUMPS ("Massachusetts General Hospital Utility Multi-Programming System"), or M, is an imperative, high-level programming language with an integrated transaction processing key–value database. It was originally developed at Massachusetts Gener ...
infections, resulting in serious illness and deaths. His continued claims that the vaccine is harmful have contributed to a climate of distrust of all vaccines and the reemergence of other previously controlled diseases. The Associated Press said: WWAY, an
ABC ABC are the first three letters of the Latin script known as the alphabet. ABC or abc may also refer to: Arts, entertainment, and media Broadcasting * American Broadcasting Company, a commercial U.S. TV broadcaster ** Disney–ABC Television ...
affiliate in Wilmington, North Carolina, said: Paul Hébert, editor-in-chief of the ''
Canadian Medical Association Journal The ''Canadian Medical Association Journal'' (French ''Journal de l'Association Médicale Canadienne'') is a peer-reviewed general medical journal published by the Canadian Medical Association (CMA). It publishes original clinical research, anal ...
'' (CMAJ) said: A profile in a '' New York Times Magazine'' article commented:Journalist Brian Deer called for criminal charges against Wakefield. On 1 April 2011, the James Randi Educational Foundation awarded Wakefield the
Pigasus Award The Pigasus Award is the name of an annual tongue-in-cheek award that was presented by noted skeptic James Randi. The award seeks to expose parapsychological, paranormal or psychic frauds that Randi had noted over the previous year. Randi ...
for "refusal to face reality". A 2011 journal article described the vaccine-autism connection as "the most damaging medical hoax of the last 100 years". In 2011, Wakefield was at the top of the list of the worst doctors of 2011 in '' Medscape's'' list of "Physicians of the Year: Best and Worst". In January 2012, '' Time'' magazine named Wakefield in a list of "Great Science Frauds". In 2012 he was awarded the Lifetime Achievement in Quackery award by the Good Thinking Society. A writer from ''The New York Times'', who was covering a 2011 event in
Tomball, Texas Tomball ( ) is a city in Harris County in the U.S. state of Texas, a part of the Houston metropolitan area. The population was 12,341 at the 2020 U.S. census. In 1907, the community of Peck was renamed Tomball for local congressman Thomas Henry B ...
where Wakefield spoke, was threatened by its organizer, Michelle Guppy: "Be nice to him, or we will hurt you." Guppy is the coordinator of the Houston Autism Disability Network. In June 2012, a local court in Rimini, Italy, ruled that the MMR vaccination had caused autism in a 15-month-old boy. The court relied heavily on Wakefield's discredited ''Lancet'' paper and largely ignored the scientific evidence presented to it. The decision was appealed. On 13 February 2015, the decision was overturned by a Court of Appeals in Bologna. In February 2015, Wakefield denied that he bore any responsibility for the measles epidemic that started at
Disneyland Disneyland is a theme park in Anaheim, California. Opened in 1955, it was the first theme park opened by The Walt Disney Company and the only one designed and constructed under the direct supervision of Walt Disney. Disney initially envision ...
. He also reaffirmed his discredited belief that "MMR contributes to the current autism epidemic". By that time at least 166 measles cases had been reported.
Paul Offit Paul Allan Offit (born March 27, 1951) is an American pediatrician specializing in infectious diseases, vaccines, immunology, and virology. He is the co-inventor of a rotavirus vaccine. Offit is the Maurice R. Hilleman Professor of Vaccinology, ...
did not agree, saying that the outbreak was "directly related to Dr. Wakefield's theory". Filmmaker Miranda Bailey followed Wakefield and his wife Carmel and their children for five years filming a documentary about Wakefield as a person, ''The Pathological Optimist''. According to Robert Ladendorf writing for ''
Skeptical Inquirer ''Skeptical Inquirer'' is a bimonthly American general-audience magazine published by the Committee for Skeptical Inquiry (CSI) with the subtitle: ''The Magazine for Science and Reason''. Mission statement and goals Daniel Loxton, writing in 2 ...
'' magazine, Bailey attempted to remain neutral and add a "human touch", which Ladendorf says was successful. Wakefield is shown "as a soft-spoken but beleaguered family man trying to resurrect his reputation and raising money for his legal fund." In 2018, ''The Skeptic'' awarded Wakefield the Rusty Razor award "for pseudoscience and bad critical thinking." The award is decided annually by readers' votes. Editor Deborah Hyde said, "Our contributors clearly felt that anti-vaccination damage is still a current issue, despite Mr. Wakefield first having come to public attention so long ago. These childhood diseases can do real damage, so we're proud to be an organisation that gets the good news out there – the evidence is overwhelming that vaccination is safe. Protect your children and your community by using it." In 2022, Wakefield's fraudulent study was included on a list of "11 of the biggest lies in history".


Political activism

Wakefield was scheduled to testify before the Oregon Senate Health Care Committee on 9 March 2015, in opposition to Senate Bill 442, "a bill that would eliminate nonmedical exemptions from Oregon's school immunization law". The Oregon Chiropractic Association had invited him. The chairman of the committee then canceled the meeting "after it became clear that" Wakefield planned to testify. She denied that her decision had anything to do with Wakefield's plans. On 24 April 2015, Wakefield received two standing ovations from the students at
Life Chiropractic College West Life Chiropractic College West is a private chiropractic school in Hayward, California, US, known for its Doctor of Chiropractic degree program. Founded as Pacific States Chiropractic College in 1976 by George E. Anderson, the name was changed in ...
when he told them to oppose Senate Bill 277 (SB 277), a bill that proposes elimination of non-medical vaccine exemptions. Wakefield had previously been a featured speaker at a 2014 "California Jam" gathering of chiropractors, as well as a 2015 "California Jam" seminar, with
continuing education Continuing education (similar to further education in the United Kingdom and Ireland) is an all-encompassing term within a broad list of post-secondary learning activities and programs. The term is used mainly in the United States and Canada. ...
credits, sponsored by Life Chiropractic College West. On 3 July 2015, Wakefield participated in a protest held in Santa Monica, California, against SB 277, a recently enacted bill which removed the personal belief exemption to school vaccine requirements in California state law. Regarding his anti-vaccine advocacy, Wakefield has been described as a
conspiracy theorist A conspiracy theory is an explanation for an event or situation that invokes a conspiracy by sinister and powerful groups, often political in motivation, when other explanations are more probable.Additional sources: * * * * The term has a nega ...
in ''
ThinkProgress ''ThinkProgress'' was an American progressive news website that was active from 2005 to 2019. It was a project of the Center for American Progress Action Fund (CAP Action), a progressive public policy research and advocacy organization. Founded ...
'', '' The Washington Post'', '' The Guardian'', the '' Los Angeles Times'', '' Forbes'', ''
Wired ''Wired'' (stylized as ''WIRED'') is a monthly American magazine, published in print and online editions, that focuses on how emerging technologies affect culture, the economy, and politics. Owned by Condé Nast, it is headquartered in San Fran ...
'', the Johns Hopkins Bloomberg School of Public Health and by
Paul Offit Paul Allan Offit (born March 27, 1951) is an American pediatrician specializing in infectious diseases, vaccines, immunology, and virology. He is the co-inventor of a rotavirus vaccine. Offit is the Maurice R. Hilleman Professor of Vaccinology, ...
.


''Vaxxed'' film

In 2016, Wakefield directed the anti-vaccination propaganda film ''Vaxxed: From Cover-Up to Catastrophe.'' The film purports to show "an appalling cover-up committed by the government agency charged with protecting the health of American citizens he_US_Centers_for_Disease_Control_and_Prevention_(CDC).html" ;"title="Centers for Disease Control and Prevention">he US Centers for Disease Control and Prevention (CDC)">Centers for Disease Control and Prevention">he US Centers for Disease Control and Prevention (CDC)... an alarming deception that has contributed to the skyrocketing increase of autism and potentially the most catastrophic epidemic of our lifetime." The film was withdrawn from New York's 2016 Tribeca Film Festival after the festival's founder Robert De Niro (who has a child with autism) reversed his decision to include it. The film was also scheduled to be projected at the Mairie de Paris but was then moved to a small private cinema. Wakefield called this action censorship. Ian Lipkin, professor of epidemiology and director of the Center for Infection and Immunity at the
Columbia University Mailman School of Public Health The Joseph L. Mailman School of Public Health is the public health graduate school of Columbia University. Located on the Columbia University Medical Center campus in the Washington Heights neighborhood of Manhattan, New York City, the school ...
, writing in '' The Wall Street Journal'', said: "If ''Vaxxed'' had been submitted as science fiction, it would merit attention for its story line, character development and dialogue. But as a documentary it misrepresents what science knows about autism, undermines public confidence in the safety and efficacy of vaccines, and attacks the integrity of legitimate scientists and public-health officials".


Selected publications


Books

*


Journal articles

* Withdrawn: * Retracted: :* Retraction: * Retracted: :* Retraction: * * * *


See also

* H. Hugh Fudenberg *
List of scientific misconduct incidents Scientific misconduct is the violation of the standard codes of scholarly conduct and ethical behavior in the publication of professional scientific research. A '' Lancet'' review on ''Handling of Scientific Misconduct in Scandinavian countries ...


Notes


References


External links

* * * * * * Updated March 2015. * {{DEFAULTSORT:Wakefield, Andrew 1956 births Living people Academic scandals Alumni of Imperial College London Alumni of St Mary's Hospital Medical School British anti-vaccination activists Autism pseudoscience British conspiracy theorists English fraudsters Health fraud Medical controversies in the United Kingdom Medical doctors struck off by the General Medical Council Medical scandals in the United Kingdom Place of birth missing (living people) People educated at King Edward's School, Bath People involved in scientific misconduct incidents MMR vaccine and autism