Amgen Inc. (formerly Applied Molecular Genetics Inc.) is an American multinational

biopharmaceutical A biopharmaceutical, also known as a biological medical product, or biologic, is any pharmaceutical drug product manufactured in, extracted from, or semisynthesized from biological sources. Different from totally synthesized pharmaceuticals, t ...

company A company, abbreviated as co., is a Legal personality, legal entity representing an association of people, whether Natural person, natural, Legal person, legal or a mixture of both, with a specific objective. Company members share a common p ...

headquartered in

Thousand Oaks, California Thousand Oaks is the second-largest city in Ventura County, California, United States. It is in the northwestern part of Greater Los Angeles, approximately from the city of Los Angeles and from Downtown Los Angeles, Downtown. It is named af ...

. One of the world's largest independent

biotechnology Biotechnology is the integration of natural sciences and engineering sciences in order to achieve the application of organisms, cells, parts thereof and molecular analogues for products and services. The term ''biotechnology'' was first used b ...

companies, Amgen was established in Thousand Oaks, California, in 1980.Baker, Pam (2002). ''Thousand Oaks Westlake Village: A Contemporary Portrait''. Community Communications, Inc. Page 37. . Amgen's Thousand Oaks staff in 2017 numbered 5,125 (7.5% of total city employment) and included hundreds of scientists, making Amgen the largest employer in

Ventura County Ventura County () is a county in the southern part of the U.S. state of California. As of the 2020 census, the population was 843,843. The largest city is Oxnard, and the county seat is the city of Ventura. Ventura County comprises the Oxnar ...

. Focused on

molecular biology Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physi ...

and

biochemistry Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and ...

, its goal is to provide a healthcare business based on

recombinant DNA technology Molecular cloning is a set of experimental methods in molecular biology that are used to assemble recombinant DNA molecules and to direct their replication within host organisms. The use of the word ''cloning'' refers to the fact that the metho ...

. In 2018, the company's largest selling product lines were

Neulasta Pegfilgrastim, sold under the brand name Neulasta among others, is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (GCSF) analog filgrastim. It serves to stimulate the production of white blood cells ( neutrophi ...

, an

immunostimulator Immunostimulants, also known as immunostimulators, are substances (drugs and nutrients) that stimulate the immune system by inducing activation or increasing activity of any of its components. One notable example is the granulocyte macrophage colo ...

used to prevent infections in patients undergoing cancer chemotherapy and

Enbrel Etanercept, sold under the brand name Enbrel among others, is a biologic medical product that is used to treat autoimmune diseases by interfering with tumor necrosis factor (TNF), a soluble inflammatory cytokine, by acting as a TNF inhibitor. It h ...

, a

tumor necrosis factor Tumor necrosis factor (TNF, cachexin, or cachectin; formerly known as tumor necrosis factor alpha or TNF-α) is an adipokine and a cytokine. TNF is a member of the TNF superfamily, which consists of various transmembrane proteins with a homolog ...

blocker used in the treatment of

rheumatoid arthritis Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. It typically results in warm, swollen, and painful joints. Pain and stiffness often worsen following rest. Most commonly, the wrist and hands are involv ...

and other autoimmune diseases. Other products include

Epogen Epoetin alfa is a human erythropoietin produced in cell culture using recombinant DNA technology. Authorised by the European Medicines Agency on 28 August 2007, it stimulates erythropoiesis (increasing red blood cell levels) and is used to treat ...

Aranesp Darbepoetin alfa (INN) is a re-engineered form of erythropoietin containing 5 amino acid changes (N30, T32, V87, N88, T90) resulting in the creation of 2 new sites for N-linked carbohydrate addition. It has a 3-fold longer serum half-life compare ...

Sensipar Cinacalcet, sold under the brand name Sensipar among others, is a medication used to treat tertiary hyperparathyroidism, parathyroid carcinoma, and primary hyperparathyroidism. Text was copied from this source which is © European Medicines Agenc ...

Mimpara Cinacalcet, sold under the brand name Sensipar among others, is a medication used to treat tertiary hyperparathyroidism, parathyroid carcinoma, and primary hyperparathyroidism. Text was copied from this source which is © European Medicines Agenc ...

Nplate Romiplostim, sold under the brand name Nplate among others, is a fusion protein analog of thrombopoietin, a hormone that regulates platelet production. Indications and Marketing The drug was developed by Amgen through a restricted usage program ...

Vectibix Panitumumab, sold under the brand name Vectibix, is a fully human monoclonal antibody specific to the epidermal growth factor receptor (also known as ''EGF receptor'', ''EGFR'', ''ErbB-1'' and ''HER1'' in humans). Panitumumab is manufactured by ...

Prolia Denosumab (trade names Prolia and Xgeva) is a human monoclonal antibody for the treatment of osteoporosis, treatment-induced bone loss, metastases to bone, and giant cell tumor of bone. Denosumab is contraindicated in people with low blood calci ...

and

XGEVA Denosumab (trade names Prolia and Xgeva) is a human monoclonal antibody for the treatment of osteoporosis, treatment-induced bone loss, metastases to bone, and giant cell tumor of bone. Denosumab is contraindicated in people with low blood calci ...

. Amgen sponsored the

Tour of California The Tour of California (officially sponsored as the Amgen Tour of California) was an annual professional road bicycle racing, road cycling stage race on the UCI World Tour and USA Cycling Professional Tour that ran from 2006 to 2019. It was the ...

from 2011 to 2017.

History

The word AMGen is a

portmanteau A portmanteau word, or portmanteau (, ) is a blend of wordsinitial public offering An initial public offering (IPO) or stock launch is a public offering in which shares of a company are sold to institutional investors and usually also to retail (individual) investors. An IPO is typically underwritten by one or more investment ...

). The company's first

chief executive officer A chief executive officer (CEO), also known as a central executive officer (CEO), chief administrator officer (CAO) or just chief executive (CE), is one of a number of corporate executives charged with the management of an organization especially ...

, from 1980, was co-founder

George B. Rathmann George Blatz Rathmann (1927–2012) was an American chemist, biologist, pioneer in biotechnology and corporate executive. In 1980 he co-founded and served as the first CEO of Amgen, and later founded Icos. Background Rathmann was born on Decemb ...

, followed by Gordon M. Binder in 1988, followed by

Kevin W. Sharer Kevin W. Sharer (born March 2, 1948), is an American businessman who was chairman/CEO of the biotechnology company Amgen from 2000 to 2012. He later joined the faculty of Harvard Business School teaching RC Strategy and General Management. Educ ...

in 2000. Robert A. Bradway became Amgen’s president and chief executive officer in May 2012 following Sharer's retirement. The company has made at least five major corporate acquisitions.

Timeline

*1980. William Bowes from Cetus Corporation recruits Winston Salser from UCLA to start Amgen with a scientific advisory board consisting of Norman Davidson,

Leroy Hood Leroy "Lee" Edward Hood (born October 10, 1938) is an American biologist who has served on the faculties at the California Institute of Technology (Caltech) and the University of Washington. Hood has developed ground-breaking scientific instrum ...

, Arnold Berk, John Carbon, Robert Schimke,

Arno Motulsky Arno Gunther Motulsky (5 July 1923 – 17 January 2018) was a professor of medical genetics and genome sciences at the University of Washington. Through his research, writing and mentoring, he helped create and define the field of medical genetic ...

, Marvin H. Caruthers, and Dave Gibson. *1989. Amgen received approval for the first recombinant human erythropoetin product, Epogen, for the treatment of anemia associated with chronic kidney failure. Epogen (also marketed by Johnson and Johnson under the tradename Procrit) would later be approved for anemia due to cancer chemotherapy, anemia due to treatment with certain HIV drugs, and for the reduction of the need for transfusions associated with surgery. * 1991. In February 1991, Amgen received FDA approval for Neupogen for the prevention of infections in patients whose immune systems are suppressed due to cancer chemotherapy. A 2002 meta-analysis found that Neupogen treatment reduced the risk of febrile neutropenia by 38%, reduced the risk of documented infection by 49%, and reduced the risk of infection-related mortality by 40%. * 1998. In November 1998, Immunex, a future acquisition of Amgen, received approval for Enbrel (etanercept), the first rheumatoid arthritis drug targeting tumor necrosis factor alpha (TNF-alpha). A 2006 assessment by the National Institute of Clinical Excellence of the United Kingdom concluded that etanercept and related rheumatoid arthritis drugs later introduced by competitors "are effective treatments compared with placebo for RA patients who are not well controlled by conventional DMARDs, improving control of symptoms, improving physical function, and slowing radiographic changes in joints." A more recent study demonstrated that compared to traditional disease-modifying anti-rheumatic drugs, treatment with etanercept improved survival, reduced cardiovascular events and reduced the incidence of hematological cancers. * 2010. On June 6, 2010 Amgen received

FDA The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food ...

approval for Prolia, a protein drug for the treatment of post-menopausal osteoporosis. In clinical trials, Prolia reduced the rate of vertebral fractures by 61% and the risk of hip fractures by 40%. * 2010 In November 2010 the

approved Xgeva for the prevention of complications of bone metastases in patients with solid tumors. The clinical trials primarily enrolled patients with breast or prostate cancer. * 2012. Illegal marketing practices. The ''

Los Angeles Times The ''Los Angeles Times'' (abbreviated as ''LA Times'') is a daily newspaper that started publishing in Los Angeles in 1881. Based in the LA-adjacent suburb of El Segundo since 2018, it is the sixth-largest newspaper by circulation in the Un ...

'' reported on December 18, 2012 that Amgen pleaded guilty and agreed to pay $150 million in criminal penalty and $612 million to resolve 11 related

whistleblower A whistleblower (also written as whistle-blower or whistle blower) is a person, often an employee, who reveals information about activity within a private or public organization that is deemed illegal, immoral, illicit, unsafe or fraudulent. Whi ...

complaints. Federal prosecutors accused the company of pursuing profits while putting patients at risk. Larry Husten, a contributor at Forbes.com elaborates on AMGEN's illegal marketing practices in this case, namely that the "government accused Amgen of marketing Aranesp for indications not approved by the FDA and other illegal marketing practices". One of the drugs mentioned in the lawsuit had sales of $492 million in the third quarter of 2012, down 17% from the same quarter the previous year due to "reimbursement problems and label changes". * 2013. Lawmakers inserted text into the fiscal cliff bill that will allow the drugmaker to sell a class of drugs that includes Sensipar without government controls for an additional two years. The New York Times estimated that the paragraph in the fiscal cliff bill will cost taxpayers an estimated $500 million but other assessments concluded that the change would protect seniors in rural areas and reduce overall Medicare spending. *2015. In September the company announced it would acquire Dezima Pharma for more than $1.55 billion. The same day the company announced a collaboration with Xencor on 6 early stage immuno-oncology and inflammation programmes. As part of the deal Amgen will pay $45 million upfront, with the deal being worth up to another $1.7 billion. *2016. In September, the company announced it would purchase the rights to Boehringer Ingelheims Phase I bispecific T-cell engager compound (BI 836909, now AMG 420) for use in the treatment of

multiple myeloma Multiple myeloma (MM), also known as plasma cell myeloma and simply myeloma, is a cancer of plasma cells, a type of white blood cell that normally produces antibodies. Often, no symptoms are noticed initially. As it progresses, bone pain, an ...

. *2017. Cash returned to shareholders totalled a record $6.5 billion through dividends and share repurchases. *2018. Amgen was ranked 123 on the Fortune 500 list of the largest United States corporations by revenue. *2019. Amgen announced it would acquire Nuevolution AB for 1.61 billion Swedish crowns ($166.8 million) to enhance its drug discovery capabilities. In August the company announced it would acquire the

Otezla Apremilast, sold under the brand name Otezla among others, is a medication for the treatment of certain types of psoriasis and psoriatic arthritis. It may also be useful for other immune system-related inflammatory diseases. The drug acts as a se ...

drug programme from

Celgene Celgene Corporation is a pharmaceutical company that makes cancer and immunology drugs. Its major product is Revlimid ( lenalidomide), which is used in the treatment of multiple myeloma, and also in certain anemias. The company is incorporated i ...

for $13.4 billion, as part of Celgene and

Bristol-Myers Squibb The Bristol Myers Squibb Company (BMS) is an American multinational pharmaceutical company. Headquartered in New York City, BMS is one of the world's largest pharmaceutical companies and consistently ranks on the ''Fortune'' 500 list of the lar ...

s merger deal. In October, Amgen announced it would be acquiring a 20.5% stake in the

Beijing } Beijing ( ; ; ), alternatively romanized as Peking ( ), is the capital of the People's Republic of China. It is the center of power and development of the country. Beijing is the world's most populous national capital city, with over 21 ...

-based BeiGene for $2.7 billion. In November, Amgen awarded a $2 million grant to the

CDC Foundation The Centers for Disease Control and Prevention (CDC) is the national public health agency of the United States. It is a United States federal agency, under the Department of Health and Human Services, and is headquartered in Atlanta, Georgi ...

to launch the latter's EmPOWERED Health Program, promoting patient engagement in decision making for their cancer treatment. *2021. In March, the company announced it would acquire Five Prime Therapeutics and its lead candidate, bemarituzumab, for $1.9 billion and Rodeo Therapeutics for up to $720 million. In July, Amgen acquired Teneobio for $900 million. *2022. In August, the company agreed to acquire ChemoCentryx for $3.7 billion in an all-cash deal. ChemoCentryx is the maker of

Tavneos Avacopan, sold under the brand name Tavneos, is a medication used to treat anti-neutrophil cytoplasmic autoantibody-associated vasculitis. Avacopan is a complement 5a receptor antagonist and a cytochrome P450 3A4 inhibitor. The most common s ...

—a drug treatment for rare diseases called anti-neutrophil cytoplasmic autoantibody-associated

vasculitis Vasculitis is a group of disorders that destroy blood vessels by inflammation. Both arteries and veins are affected. Lymphangitis (inflammation of lymphatic vessels) is sometimes considered a type of vasculitis. Vasculitis is primarily caused b ...

—which was approved last year. In December, the company announced it would acquire Horizon Therapeutics for $27.8 billion ($116.50 in cash for each Horizon share, a 20% premium) expanding its rare disease treatments.

Acquisition history

*Amgen (Founded 1983 as Applied Molecular Genetics) **Synergen Inc (Acq 1994) **Kinetix Pharmaceuticals Inc (Acq 2000) **Immunex Corporation (Acq 2002) **Tularik Inc (Acq 2004) **Abgenix Inc (Acq 2006) **Avidia Inc (Acq 2006) **Alantos Pharmaceuticals (Acq 2007) **Ilypsa Inc (Acq 2007) **BioVex Group Inc (Acq 2011) **Micromet Inc (Acq 2012) **Mustafa Nevzat İlaç (Acq 2012) **KAI Pharmaceuticals (Acq 2012) **

deCODE genetics deCODE genetics ( is, Íslensk erfðagreining) is a biopharmaceutical company based in Reykjavík, Iceland. The company was founded in 1996 by Kári Stefánsson with the aim of using population genetics studies to identify variations in the hum ...

(Acq 2012) **

Onyx Pharmaceuticals Onyx Pharmaceuticals Inc. has been a biopharmaceutical company headquartered in South San Francisco, California. The company developed and marketed medicines for the treatment of cancer. Onyx was founded in 1992 by Kevin J. Kinsella and Frank M ...

(Acq 2013) **NextCODE genetics (Spun off 2013) **Dezima Pharma (Acq 2015) **Catherex (Acq 2015) **Nuevolution AB (Acq 2019) **Otezla (Acq 2019) **Five Prime Therapeutics (Acq 2021) **Rodeo Therapeutics (Acq 2021) **Teneobio (Acq 2021) **ChemoCentryx (Acq 2022) ** Horizon Therapeutics (Acq announced 2022) ***Vidara Therapeutics International (Acq 2014) ***Hyperion Therapeutics (Acq 2015) ***Crealta Holdings (Acq 2015) ***Raptor Pharmaceutical (Acq 2016) ***River Vision Development Corp. (Acq 2017) ***Viela Bio Inc (Acq 2021)

Products

Amgen's approved drugs or therapeutic biologicals include: *Aimovig ( erenumab-aooe) for

migraine headaches Migraine (, ) is a common neurological disorder characterized by recurrent headaches. Typically, the associated headache affects one side of the head, is pulsating in nature, may be moderate to severe in intensity, and could last from a few ho ...

*Aranesp (

darbepoetin alfa Darbepoetin alfa (INN) is a re-engineered form of erythropoietin containing 5 amino acid changes (N30, T32, V87, N88, T90) resulting in the creation of 2 new sites for N-linked carbohydrate addition. It has a 3-fold longer serum half-life compar ...

) for

anemia Anemia or anaemia (British English) is a blood disorder in which the blood has a reduced ability to carry oxygen due to a lower than normal number of red blood cells, or a reduction in the amount of hemoglobin. When anemia comes on slowly, th ...

*Blincyto (

blinatumomab Blinatumomab, sold under the brand name Blincyto, is a biopharmaceutical medication used as a second-line treatment for Philadelphia chromosome-negative relapsed or refractory acute lymphoblastic leukemia. It belongs to a class of constructed ...

for the treatment of

acute lymphoblastic leukemia Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the development of large numbers of immature lymphocytes. Symptoms may include feeling tired, pale skin color, fever, easy bleeding or bruisin ...

) *Corlanor (

ivabradine Ivabradine, sold under the brand name Procoralan among others, is a medication, which is a funny current (I''f'') inhibitor, used for the symptomatic management of heart-related chest pain and heart failure. Patients who qualify for use of Ivab ...

) *Enbrel (

etanercept Etanercept, sold under the brand name Enbrel among others, is a biologic medical product that is used to treat autoimmune diseases by interfering with tumor necrosis factor (TNF), a soluble inflammatory cytokine, by acting as a TNF inhibitor. It ...

) for various forms of

arthritis Arthritis is a term often used to mean any disorder that affects joints. Symptoms generally include joint pain and stiffness. Other symptoms may include redness, warmth, swelling, and decreased range of motion of the affected joints. In som ...

*Epogen (

erythropoietin Erythropoietin (; EPO), also known as erythropoetin, haematopoietin, or haemopoietin, is a glycoprotein cytokine secreted mainly by the kidneys in response to cellular hypoxia; it stimulates red blood cell production (erythropoiesis) in the bo ...

) for

*Evenity ( romosozumab-aqqg) for

osteoporosis Osteoporosis is a systemic skeletal disorder characterized by low bone mass, micro-architectural deterioration of bone tissue leading to bone fragility, and consequent increase in fracture risk. It is the most common reason for a broken bone ...

*Imlygic (

talimogene laherparepvec Talimogene laherparepvec, sold under the brand name Imlygic, is a biopharmaceutical medication used to treat melanoma that cannot be operated on; it is injected directly into a subset of lesions which generates a systemic immune response against ...

) for local treatment of unresectable cutaneous, subcutaneous, and nodal lesions in melanoma recurrent after initial surgery *Kyprolis (

carfilzomib Carfilzomib, sold under the brand name Kyprolis, is an anti-cancer medication acting as a selective proteasome inhibitor. Chemically, it is a tetrapeptide epoxyketone and an analog of epoxomicin. It was developed by Onyx Pharmaceuticals. The U. ...

) *Lumakras ( sotorasib) *Neulasta (

pegfilgrastim Pegfilgrastim, sold under the brand name Neulasta among others, is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (GCSF) analog filgrastim. It serves to stimulate the production of white blood cells ( neutrophils ...

) for

neutropenia Neutropenia is an abnormally low concentration of neutrophils (a type of white blood cell) in the blood. Neutrophils make up the majority of circulating white blood cells and serve as the primary defense against infections by destroying bacteria ...

*Neupogen (

granulocyte colony-stimulating factor Granulocyte colony-stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream. Functiona ...

) for

*Nplate (

romiplostim Romiplostim, sold under the brand name Nplate among others, is a fusion protein analog of thrombopoietin, a hormone that regulates platelet production. Indications and Marketing The drug was developed by Amgen through a restricted usage program ...

) for chronic

immune thrombocytopenic purpura Immune thrombocytopenic purpura (ITP), also known as idiopathic thrombocytopenic purpura or immune thrombocytopenia, is a type of thrombocytopenic purpura defined as an isolated low platelet count with a normal bone marrow in the absence of othe ...

*Parsabiv (

etelcalcetide Etelcalcetide (formerly velcalcetide, trade name Parsabiv) is a calcimimetic drug for the treatment of secondary hyperparathyroidism in patients undergoing hemodialysis. It is administered intravenously at the end of each dialysis session. Etelcal ...

) *Prolia (

denosumab Denosumab (trade names Prolia and Xgeva) is a human monoclonal antibody for the treatment of osteoporosis, treatment-induced bone loss, metastases to bone, and giant cell tumor of bone. Denosumab is contraindicated in people with low blood calci ...

) for postmenopausal

*Repatha (

evolocumab Evolocumab (trade name Repatha) is a monoclonal antibody medication designed for the treatment of hyperlipidemia. Evolocumab is a fully human monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9). PCSK9 is a pro ...

) *Sensipar/Mimpara (

cinacalcet Cinacalcet, sold under the brand name Sensipar among others, is a medication used to treat tertiary hyperparathyroidism, parathyroid carcinoma, and primary hyperparathyroidism. Text was copied from this source which is © European Medicines Agenc ...

for primary and

secondary hyperparathyroidism Secondary hyperparathyroidism is the medical condition of excessive secretion of parathyroid hormone (PTH) by the parathyroid glands in response to hypocalcemia (low blood calcium levels), with resultant hyperplasia of these glands. This disorde ...

, a mineral metabolism complication common in patients with kidney failure) *Tezspire ( tezepelumab) for asthma *Vectibix (

panitumumab Panitumumab, sold under the brand name Vectibix, is a fully human monoclonal antibody specific to the epidermal growth factor receptor (also known as ''EGF receptor'', ''EGFR'', ''ErbB-1'' and ''HER1'' in humans). Panitumumab is manufactured by ...

for

colon cancer Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, is the development of cancer from the colon or rectum (parts of the large intestine). Signs and symptoms may include blood in the stool, a change in bowel mo ...

) *Xgeva (

) for the prevention of skeletal-related events (pathological fracture, radiation to bone, spinal cord compression or surgery to bone in adults with bone metastases from solid tumors)

Products developed and then sold off

* Kepivance ( palifermin for

oral mucositis Mucositis is the painful inflammation and ulceration of the mucous membranes lining the digestive tract, usually as an adverse effect of chemotherapy and radiotherapy treatment for cancer. Mucositis can occur anywhere along the gastrointestinal ( ...

, sold to Biovitrium, now Swedish Orphan Biovitrum, in December 2008Amgen press office
Biovitrum Closes Product Acquisition Deal with Amgen
*StemGen (

ancestim Ancestim is a recombinant methionyl human stem cell factor, branded by Amgen as StemGen. It was developed by Amgen and sold to Biovitrium, now Swedish Orphan Biovitrum, in December, 2008.Amgen press officeBiovitrum Closes Product Acquisition Dea ...

) for use in combination with

filgrastim Filgrastim, sold under the brand name Neupogen among others, is a medication used to treat low neutrophil count. Low neutrophil counts may occur with HIV/AIDS, following chemotherapy or radiation poisoning, or be of an unknown cause. It may ...

for mobilizing peripheral

hematopoietic stem cells Hematopoietic stem cells (HSCs) are the stem cells that give rise to other blood cells. This process is called haematopoiesis. In vertebrates, the very first definitive HSCs arise from the ventral endothelial wall of the embryonic aorta within ...

) (sold to Biovitrium, now Swedish Orphan Biovitrum, in December 2008) *Kineret (

anakinra Anakinra, sold under the brand name Kineret, is a biopharmaceutical medication used to treat rheumatoid arthritis, cryopyrin-associated periodic syndromes, familial Mediterranean fever, and Still's disease. It is a recombinant and slightly modif ...

) for

, exclusively licensed to Biovitrium, now Swedish Orphan Biovitrum, in December 2008

Pipeline and clinical trials

In December 2013, Amgen had 11 drugs in Phase III

clinical trials Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietar ...

. In November 2014 the company announced it was halting all trials of rilotumumab in advanced

gastric cancer Stomach cancer, also known as gastric cancer, is a cancer that develops from the lining of the stomach. Most cases of stomach cancers are gastric carcinomas, which can be divided into a number of subtypes, including gastric adenocarcinomas. Lymph ...

patients after one of the trials found more deaths in those who took the compound with chemotherapy, than those without. Later in the same week, the company in conjunction with

AstraZeneca AstraZeneca plc () is a British-Swedish multinational pharmaceutical and biotechnology company with its headquarters at the Cambridge Biomedical Campus in Cambridge, England. It has a portfolio of products for major diseases in areas includin ...

reported positive results for

brodalumab Brodalumab, sold under the brand name Siliq in the US and Kyntheum in the EU, is a human monoclonal antibody designed for the treatment of inflammatory diseases. In February 2017, it received US FDA approval to treat moderate to severe plaque p ...

in a Phase III trial comparing the compound with

ustekinumab Ustekinumab, sold under the brand name Stelara is a monoclonal antibody medication developed by Janssen Pharmaceuticals, for the treatment of Crohn's disease, ulcerative colitis, plaque psoriasis and psoriatic arthritis, targeting both IL-12 an ...

and a

placebo A placebo ( ) is a substance or treatment which is designed to have no therapeutic value. Common placebos include inert tablets (like sugar pills), inert injections (like Saline (medicine), saline), sham surgery, and other procedures. In general ...

in treating

psoriasis Psoriasis is a long-lasting, noncontagious autoimmune disease characterized by raised areas of abnormal skin. These areas are red, pink, or purple, dry, itchy, and scaly. Psoriasis varies in severity from small, localized patches to complete ...

. In March 2015, the company announced it would license its Phase II candidate drug AMG 714 to developer Celimmune who plan to develop the anti-IL-15

monoclonal antibody A monoclonal antibody (mAb, more rarely called moAb) is an antibody produced from a cell Lineage made by cloning a unique white blood cell. All subsequent antibodies derived this way trace back to a unique parent cell. Monoclonal antibodies ca ...

for treatment against diet nonresponsive

celiac disease Coeliac disease (British English) or celiac disease (American English) is a long-term autoimmune disorder, primarily affecting the small intestine, where individuals develop intolerance to gluten, present in foods such as wheat, rye and barl ...

and refractory celiac disease. In June 2015, Amgen presented Phase II clinical trial data for their anti-

CGRP Calcitonin gene-related peptide (CGRP) is a member of the calcitonin family of peptides consisting of calcitonin, amylin, adrenomedullin, adrenomedullin 2 ( intermedin) and calcitonin‑receptor‑stimulating peptide. Calcitonin is mainly produc ...

antibody

AMG 334 Calcitonin gene-related peptide (CGRP) receptor antagonists are a class of drugs that act as antagonists of the calcitonin gene-related peptide receptor (CGRPR). Several monoclonal antibodies which binds to the CGRP receptor or peptide have been ...

for

migraine Migraine (, ) is a common neurological disorder characterized by recurrent headaches. Typically, the associated headache affects one side of the head, is pulsating in nature, may be moderate to severe in intensity, and could last from a few hou ...

, approved for sale as Aimovig in 2019. In September 2019, FDA granted

fast track designation Fast track is a designation by the United States Food and Drug Administration (FDA) of an investigational drug for expedited review to facilitate development of drugs that treat a serious or life-threatening condition and fill an unmet medical ...

to sotorasib for the treatment of metastatic

non-small-cell lung carcinoma Non-small-cell lung cancer (NSCLC) is any type of epithelial lung cancer other than small-cell lung carcinoma (SCLC). NSCLC accounts for about 85% of all lung cancers. As a class, NSCLCs are relatively insensitive to chemotherapy, compared to sm ...

(NSCLC) with the KRAS G12C mutation. In May 2021, sotorasib received accelerated approval from FDA for treatment of adult patients with NSCLC whose tumors have a KRAS G12C mutation and who have received at least one prior systemic therapy; this was the first approved targeted therapy for tumors with any KRAS mutation. Similar approvals for sotorasib in NSCLC followed in January 2022 in Europe and Japan. In September 2022, data from a late-stage study showed the company's cancer pill Lumakras beating out chemotherapy. This was the first approved drug in the set of treatments that target KRAS, among the most common generic mutations found in cancers but one where researchers have struggled for years to design drugs to treat. The drug was approved in 2021 with a list price of $17,900 per month.

Carbon footprint

Amgen reported Total CO2e emissions (Direct + Indirect) for the twelve months ending 31 December 2020 at 243 Kt (-6 /-2.4% y-o-y)Alt URL
/ref> and aims to reach net zero emissions by 2027.

Public-private engagement

Amgen engages with the public and private sectors in a variety of settings including to promote

research and development Research and development (R&D or R+D), known in Europe as research and technological development (RTD), is the set of innovative activities undertaken by corporations or governments in developing new services or products, and improving existi ...

, academic funding, event sponsorship,

philanthropy Philanthropy is a form of altruism that consists of "private initiatives, for the Public good (economics), public good, focusing on quality of life". Philanthropy contrasts with business initiatives, which are private initiatives for private goo ...

, and

political lobbying In politics, lobbying, persuasion or interest representation is the act of lawfully attempting to influence the actions, policies, or decisions of government officials, most often legislators or members of regulatory agencies. Lobbying, whi ...

Academia

Institute for Advanced Study The Institute for Advanced Study (IAS), located in Princeton, New Jersey, in the United States, is an independent center for theoretical research and intellectual inquiry. It has served as the academic home of internationally preeminent scholar ...

- Donor to various IAS campaigns, including the IAS/Park City Mathematics Institute (PCMI), the Regional Initiative in Science and Education (RISE), and the Opportunity Equation (OE). * LA Promise Fund - Sponsor of the Amgen Biotech Experience Los Angeles (ABE-LA). *

University of Toronto The University of Toronto (UToronto or U of T) is a public research university in Toronto, Ontario, Canada, located on the grounds that surround Queen's Park. It was founded by royal charter in 1827 as King's College, the first institution ...

- Donor to U of T's Boundless campaign. *

University of Washington The University of Washington (UW, simply Washington, or informally U-Dub) is a public research university in Seattle, Washington. Founded in 1861, Washington is one of the oldest universities on the West Coast; it was established in Seattle a ...

- Donor.

Events and conferences

* Alberta Kidney Days - Virtual series sponsor. * BC Kidney Days - Sponsor. * Mentoring in IBD - Sponsor. *

Princess Margaret Cancer Centre The Princess Margaret Cancer Centre (previously, ''Princess Margaret Hospital'') is a scientific research centre and a teaching hospital in Toronto, Ontario, Canada, affiliated with the University of Toronto Faculty of Medicine as part of the Univ ...

(PMCC) Conference - Sponsor.

Health care

Kingston General Hospital The Kingston General Hospital (KGH) site is an acute-care teaching hospital affiliated with Queen's University located in Kingston, Ontario, Canada. Along with the Hotel Dieu Hospital (HDH) site, these hospitals deliver health care services to ...

- Donor. *

- Donor to the Princess Margaret Cancer Foundation. * Providence Health Care - Donor. *

Scarborough Health Network Scarborough Health Network (SHN) is a hospital network in Scarborough, Toronto, Ontario, Canada. It operates the Scarborough General, Centenary, and Birchmount hospitals. The three are major community health hospitals with teaching affiliations ...

- Donor to the SHN Foundation. * SickKids - Donor to the SickKids Foundation. *

Sinai Health System The Sinai Health is a hospital system which serves Toronto, Ontario, Canada. It comprises two hospitals, Mount Sinai Hospital (Toronto), Mount Sinai Hospital (an acute care hospital) and Hennick Bridgepoint Hospital, formally Bridgepoint Active H ...

- Donor to the Sinai Health Foundation. * St. Michael's Hospital - Donor. * Sunnybrook Health Sciences Centre - Donor to the Sunnybrook Foundation. *

Unity Health Toronto Unity Health Toronto is a Catholic Church and health care, Catholic hospital network serving Toronto, Ontario, Canada. It was initially founded in 2017 under the provisional name Our Shared Purpose through the merger of St. Michael's Hospital (Tor ...

- Donor. *

University Health Network University Health Network (UHN) is a public research and teaching hospital network in Toronto, Ontario, Canada. It is the largest health research organization in Canada and ranks first in Canada for total research funding. It was named Canada's ...

- Donor to the UHN Foundation. *

Women's College Hospital Women's College Hospital is a teaching hospital in downtown Toronto, Ontario, Canada. It is located at the north end of Hospital Row, a section of University Avenue where several major hospitals are located. It currently functions as an indepen ...

- Donor.

Media

National Geographic Society The National Geographic Society (NGS), headquartered in Washington, D.C., United States, is one of the largest non-profit scientific and educational organizations in the world. Founded in 1888, its interests include geography, archaeology, and ...

- Donor.

Medical societies

American Society of Hematology The American Society of Hematology (ASH) is a professional organization representing hematologists. It was founded in 1958. Its annual meeting is held in December of every year and has attracted more than 30,000 attendees. The society publishes t ...

- Corporate funder. * Arthritis Society (Canada) - Partner. *

Canadian Society of Hospital Pharmacists The Canadian Society of Hospital Pharmacists (CSHP) is a professional organization representing the interests of pharmacists A pharmacist, also known as a chemist ( Commonwealth English) or a druggist (North American and, archaically, Common ...

- Donor to the CSHP Foundation. * Canadian Society of Nephrology - Corporate partner. *

Endocrine Society The Endocrine Society is a professional, international medical organization in the field of endocrinology and metabolism, founded in 1916 as The Association for the Study of Internal Secretions. The official name of the organization was changed ...

- Corporate liaison board member. *

European Society of Cardiology The European Society of Cardiology (ESC) is an independent non-profit, non-governmental professional association that works to advance the prevention, diagnosis and management of diseases of the heart and blood vessels, and improve scientific un ...

- Sponsor for the EORP registry programme. * Federation of Medical Women in Canada - Sponsor.

Political lobbying

* Alliance for a Stronger FDA - Member. * Alliance for Aging Research - Donor. * BIOTECanada - Member. *

Bipartisan Policy Center The Bipartisan Policy Center (BPC) is a Washington, D.C.–based think tank that promotes bipartisanship. The organization aims to combine ideas from both the Republican and Democratic parties to address challenges in the U.S. BPC focuses on iss ...

- Donor. *

The Business Council The Business Council is an organization of business leaders headquartered in Washington, D.C.Robert A. Bradway. *

- Funding partner. *

Centre for Commercialization of Regenerative Medicine Center or centre may refer to: Mathematics * Center (geometry), the middle of an object * Center (algebra), used in various contexts ** Center (group theory) ** Center (ring theory) * Graph center, the set of all vertices of minimum eccentrici ...

(CCRM) - Industry partner. *

Council on Foreign Relations The Council on Foreign Relations (CFR) is an American think tank A think tank, or policy institute, is a research institute that performs research and advocacy concerning topics such as social policy, political strategy, economics, mi ...

- Affiliate. *

European Federation of Pharmaceutical Industries and Associations The European Federation of Pharmaceutical Industries and Associations (EFPIA) is a Brussels-based trade association and lobbying organisation, founded in 1978 and representing the research-based pharmaceutical industry operating in Europe. Throug ...

(EFPIA) - Member. *

Foundation for the National Institutes of Health The Foundation for the National Institutes of Health (FNIH) is a not-for-profit, 501(c)(3) charitable organization established by the US Congress in 1990. Located in North Bethesda, MD, the FNIH raises private-sector funds, and creates and manage ...

(FNIH) - Donor. * Global Health Progress - Partner. GHP is a multinational resource hub hosted by the

International Federation of Pharmaceutical Manufacturers & Associations The International Federation of Pharmaceutical Manufacturers & Associations (IFPMA) is a trade association that represents leading innovative pharmaceutical companies at the international level and in official relations with the United Nations. I ...

(IFPMA). *

Health Products Stewardship Association Health, according to the World Health Organization, is "a state of complete physical, mental and social well-being and not merely the absence of disease and infirmity".World Health Organization. (2006)''Constitution of the World Health Organiza ...

- Member. *

Innovative Medicines Canada Innovative Medicines Canada (IMC) is a national association of pharmaceutical companies that represents the interests of the research-based pharmaceutical industry in Canada. Its membership includes biopharmaceutical companies, vaccine developers, ...

- Member company. *

(IFPMA) - Member. * Life Sciences British Columbia - Sponsor. * Mayor's Fund for Los Angeles - Disaster relief grant provider. *

National Health Council The National Health Council (NHC) is a nonprofit association of health organizations. Its members are national health-related organizations, including leading patient advocacy groups such as the American Cancer Society, the American Heart Assoc ...

- Member. *

Personalized Medicine Coalition Personalization (broadly known as customization) consists of tailoring a service or a product to accommodate specific individuals, sometimes tied to groups or segments of individuals. A wide variety of organizations use personalization to improv ...

- Member. *

Pharmaceutical Advertising Advisory Board The Pharmaceutical Advertising Advisory Board (PAAB) is a Canadian not-for-profit organization based in Pickering, Ontario. Acting as a pseudo-regulatory body, PAAB offers review and pre-clearance services recognized by Health Canada to pharmaceu ...

(PAAB) - Client. PAAB "maintains a collaborative relationship” with

Health Canada Health Canada (HC; french: Santé Canada, SC)Health Canada is the applied title under the Federal Identity Program; the legal title is Department of Health (). is the Structure of the Canadian federal government#Departments, with subsidiary unit ...

. *

Pharmaceutical Research and Manufacturers of America Pharmaceutical Research and Manufacturers of America (PhRMA, pronounced ), formerly known as the Pharmaceutical Manufacturers Association, is a trade group representing companies in the pharmaceutical industry in the United States. Founded in 195 ...

(PhRMA) - Member. * Reagan-Udall Foundation for the Food and Drug Administration - Donor. * Research!America - Member.

Professional associations

* British Columbia Pharmacy Association - Sponsor. * Canadian Association of Gastroenterology - Corporate sponsor. * Canadian Association of Radiologists - Corporate partner. * Canadian Rheumatology Association - Corporate sponsor. *

Canadian Urological Association Canadians (french: Canadiens) are people identified with the country of Canada. This connection may be residential, legal, historical or cultural. For most Canadians, many (or all) of these connections exist and are collectively the source of ...

- Corporate sponsor. * Colorectal Cancer Canada - Sponsor. *

Ontario Medical Association The Ontario Medical Association (OMA) is a membership organization that represents the political, clinical and economic interests of Ontario physicians. Practising physicians, residents, and medical students enrolled in any of the six Ontario fac ...

- Donor.

Research and development

* Alberta Kidney Disease Network - Grant provider. * Can-SOLVE CKD Network - Funding partner. *

Urban Institute The Urban Institute is a Washington, D.C.–based think tank that carries out economic and social policy research to "open minds, shape decisions, and offer solutions". The institute receives funding from government contracts, foundations and pr ...

- Donor.

References

External links

* {{Authority control Biotechnology companies of the United States Biopharmaceutical companies Companies based in Thousand Oaks, California Companies listed on the Nasdaq Companies in the Dow Jones Industrial Average Life sciences industry Multinational companies headquartered in the United States Orphan drug companies Pharmaceutical companies established in 1980 Biotechnology companies established in 1980 Pharmaceutical companies of the United States 1980 establishments in California 1980s initial public offerings

History

Timeline

Acquisition history

Products

Products developed and then sold off

Pipeline and clinical trials

Carbon footprint

Public-private engagement

Academia

Events and conferences

Health care

Media

Medical societies

Political lobbying

Professional associations

Research and development

See also

References

External links