Adolfo Ferrata (26 April 1880 in

Brescia Brescia (, locally ; lmo, link=no, label= Lombard, Brèsa ; lat, Brixia; vec, Bressa) is a city and ''comune'' in the region of Lombardy, Northern Italy. It is situated at the foot of the Alps, a few kilometers from the lakes Garda and Iseo. ...

– 9 March 1946) was an Italian

pathologist Pathology is the study of the causal, causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when us ...

and

hematologist Hematology (American and British English spelling differences#ae and oe, always spelled haematology in British English) is the branch of medicine concerned with the study of the cause, prognosis, treatment, and prevention of diseases related to ...

. In 1904 he earned his medical degree from the

University of Parma The University of Parma ( it, Università degli Studi di Parma, UNIPR) is a public university in Parma, Emilia-Romagna, Italy. It is organised in nine departments. As of 2016 the University of Parma has about 26,000 students. History During the ...

, spending the following years performing scientific research in clinics at

Parma Parma (; egl, Pärma, ) is a city in the northern Italian region of Emilia-Romagna known for its architecture, Giuseppe Verdi, music, art, prosciutto (ham), Parmigiano-Reggiano, cheese and surrounding countryside. With a population of 198,292 ...

Berlin Berlin ( , ) is the capital and largest city of Germany by both area and population. Its 3.7 million inhabitants make it the European Union's most populous city, according to population within city limits. One of Germany's sixteen constitue ...

and

Naples Naples (; it, Napoli ; nap, Napule ), from grc, Νεάπολις, Neápolis, lit=new city. is the regional capital of Campania and the third-largest city of Italy, after Rome and Milan, with a population of 909,048 within the city's adminis ...

. From 1921 to 1924 he was a professor of special medical pathology at the Universities of

Messina Messina (, also , ) is a harbour city and the capital of the Italian Metropolitan City of Messina. It is the third largest city on the island of Sicily, and the 13th largest city in Italy, with a population of more than 219,000 inhabitants in ...

and

Siena Siena ( , ; lat, Sena Iulia) is a city in Tuscany, Italy. It is the capital of the province of Siena. The city is historically linked to commercial and banking activities, having been a major banking center until the 13th and 14th centuri ...

, afterwards serving as a professor of clinical medicine at the

University of Pavia The University of Pavia ( it, Università degli Studi di Pavia, UNIPV or ''Università di Pavia''; la, Alma Ticinensis Universitas) is a university located in Pavia, Lombardy, Italy. There was evidence of teaching as early as 1361, making it one ...

, a position he kept for the remainder of his career. Among his contributions to medical science are investigations on the structure and

embryology Embryology (from Greek ἔμβρυον, ''embryon'', "the unborn, embryo"; and -λογία, '' -logia'') is the branch of animal biology that studies the prenatal development of gametes (sex cells), fertilization, and development of embryos and ...

of the

kidney The kidneys are two reddish-brown bean-shaped organs found in vertebrates. They are located on the left and right in the retroperitoneal space, and in adult humans are about in length. They receive blood from the paired renal arteries; blood ...

, research on the

morphology Morphology, from the Greek and meaning "study of shape", may refer to: Disciplines * Morphology (archaeology), study of the shapes or forms of artifacts * Morphology (astronomy), study of the shape of astronomical objects such as nebulae, galaxies ...

intestinal villi Intestinal villi (singular: villus) are small, finger-like projections that extend into the lumen of the small intestine. Each villus is approximately 0.5–1.6 mm in length (in humans), and has many microvilli projecting from the enterocy ...

and

haematopoietic Haematopoiesis (, from Greek , 'blood' and 'to make'; also hematopoiesis in American English; sometimes also h(a)emopoiesis) is the formation of blood cellular components. All cellular blood components are derived from haematopoietic stem cells. ...

studies in normal and pathological conditions. In his research of

haematopoiesis Haematopoiesis (, from Greek , 'blood' and 'to make'; also hematopoiesis in American English; sometimes also h(a)emopoiesis) is the formation of blood cellular components. All cellular blood components are derived from haematopoietic stem cells. ...

, Ferrata helped demonstrate the systemic nature of

leukemia Leukemia ( also spelled leukaemia and pronounced ) is a group of blood cancers that usually begin in the bone marrow and result in high numbers of abnormal blood cells. These blood cells are not fully developed and are called ''blasts'' or ' ...

, leading him to support an hypothesis that elements of the blood (

erythrocytes Red blood cells (RBCs), also referred to as red cells, red blood corpuscles (in humans or other animals not having nucleus in red blood cells), haematids, erythroid cells or erythrocytes (from Greek ''erythros'' for "red" and ''kytos'' for "holl ...

leukocytes White blood cells, also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders. All white blood cells are produced and derived from mult ...

, and

blood platelets Platelets, also called thrombocytes (from Greek θρόμβος, "clot" and κύτος, "cell"), are a component of blood whose function (along with the coagulation factors) is to react to bleeding from blood vessel injury by clumping, thereby ini ...

) all originate from the

hemocytoblast Hematopoietic stem cells (HSCs) are the stem cells that give rise to other blood cells. This process is called haematopoiesis. In vertebrates, the very first definitive HSCs arise from the ventral endothelial wall of the embryonic aorta within ...

, a direct descendant of a

mesenchymal cell Mesenchymal stem cells (MSCs) also known as mesenchymal stromal cells or medicinal signaling cells are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cel ...

, which he referred to as an ''emoistioblasto'' (hemohistioblast). In 1907 he was the first scientist to show that the

complement A complement is something that completes something else. Complement may refer specifically to: The arts * Complement (music), an interval that, when added to another, spans an octave ** Aggregate complementation, the separation of pitch-class ...

could be split into two components that were singularly inactive, only regaining their activity when reunited. In 1920 Ferrata founded the journal "

Haematologica ''Haematologica'' is a monthly, peer reviewed, scientific journal, published by the Ferrata Storti Foundation. The editor in chief is Dr. Jacob M. Rowe (Rambam Medical Center, Haifa, Israel). The focus of ''Haematologica'' is all topics related t ...

Associated eponym

* "Ferrata cell": A primordial

, also known as an hemohistioblast (hematohistioblast).Medilexicon
(definition of eponym)

References

{{DEFAULTSORT:Ferrata, Adolfo Italian pathologists Italian hematologists People from Brescia Academic staff of the University of Pavia 1880 births 1946 deaths University of Parma alumni Academic staff of the University of Messina Academic staff of the University of Siena