Sir Aaron Klug (11 August 1926 – 20 November 2018) was a British

biophysicist Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study biological phenomena. Biophysics covers all scales of biological organization, from molecular to organismic and populations. Bi ...

and chemist. He was a winner of the 1982

Nobel Prize in Chemistry ) , image = Nobel Prize.png , alt = A golden medallion with an embossed image of a bearded man facing left in profile. To the left of the man is the text "ALFR•" then "NOBEL", and on the right, the text (smaller) "NAT•" then "M ...

for his development of crystallographic electron microscopy and his structural elucidation of biologically important

nucleic acid Nucleic acids are biopolymers, macromolecules, essential to all known forms of life. They are composed of nucleotides, which are the monomers made of three components: a 5-carbon sugar, a phosphate group and a nitrogenous base. The two main ...

protein complexes A protein complex or multiprotein complex is a group of two or more associated polypeptide chains. Protein complexes are distinct from multienzyme complexes, in which multiple catalytic domains are found in a single polypeptide chain. Protein ...

Early life and education

Klug was born in

Želva Želva ( pl, Pozelwa) is a town in Ukmergė district municipality, Vilnius County, east Lithuania. According to the Lithuanian census of 2011, the town has a population of 457 people. History The town has a Catholic church and a synagogue. Želv ...

, in Lithuania, to

Jewish Jews ( he, יְהוּדִים, , ) or Jewish people are an ethnoreligious group and nation originating from the Israelites Israelite origins and kingdom: "The first act in the long drama of Jewish history is the age of the Israelites""The ...

parents Lazar, a cattleman, and Bella (née Silin) Klug, with whom he moved to South Africa at the age of two. He was educated at

Durban High School Durban High School is an all-boys public school in Durban, South Africa. DHS opened its doors in 1866 in two rooms and with seven pupils in Smith Street. From there it moved to a disused granary in Cato Square in 1880, just after the Zulu ...

. Paul de Kruif's 1926 book, '' Microbe Hunters'', aroused his interest in microbiology. He started to study microbiology, but then moved into physics and maths, graduating with a

Bachelor of Science A Bachelor of Science (BS, BSc, SB, or ScB; from the Latin ') is a bachelor's degree awarded for programs that generally last three to five years. The first university to admit a student to the degree of Bachelor of Science was the University o ...

degree at the

University of the Witwatersrand The University of the Witwatersrand, Johannesburg (), is a multi-campus South African public research university situated in the northern areas of central Johannesburg. It is more commonly known as Wits University or Wits ( or ). The university ...

, in Johannesburg. He studied physics and obtained his

Master of Science A Master of Science ( la, Magisterii Scientiae; abbreviated MS, M.S., MSc, M.Sc., SM, S.M., ScM or Sc.M.) is a master's degree in the field of science awarded by universities in many countries or a person holding such a degree. In contrast t ...

degree at the

University of Cape Town The University of Cape Town (UCT) ( af, Universiteit van Kaapstad, xh, Yunibesithi ya yaseKapa) is a public research university in Cape Town, South Africa. Established in 1829 as the South African College, it was granted full university statu ...

. He was awarded an

1851 Research Fellowship The 1851 Research Fellowship is a scheme conducted by the Royal Commission for the Exhibition of 1851 to annually award a three-year research scholarship to approximately eight "young scientists or engineers of exceptional promise". The fellowship ...

from the

Royal Commission for the Exhibition of 1851 The Royal Commission for the Exhibition of 1851 is an institution founded in 1850 to administer the international exhibition of 1851, officially called the Great Exhibition of the Works of Industry of all Nations. The Great Exhibition was held ...

, which enabled him to move to England, completing his PhD in research physics at

Trinity College, Cambridge Trinity College is a constituent college of the University of Cambridge. Founded in 1546 by King Henry VIII, Trinity is one of the largest Cambridge colleges, with the largest financial endowment of any college at either Cambridge or Oxford. ...

in 1953.

Career and research

Following his PhD, Klug moved to

Birkbeck College , mottoeng = Advice comes over nightTranslation used by Birkbeck. , established = , type = Public research university , endowment = £4.3 m (2014) , budget = £10 ...

in the

University of London The University of London (UoL; abbreviated as Lond or more rarely Londin in post-nominals) is a federal public research university located in London, England, United Kingdom. The university was established by royal charter in 1836 as a degr ...

in late 1953, and started working with virologist

Rosalind Franklin Rosalind Elsie Franklin (25 July 192016 April 1958) was a British chemist and X-ray crystallographer whose work was central to the understanding of the molecular structures of DNA (deoxyribonucleic acid), RNA (ribonucleic acid), viruses, ...

in the lab of crystallographer John Bernal. This experience aroused a lifelong interest in the study of viruses, and during his time there he made discoveries in the structure of the

tobacco mosaic virus ''Tobacco mosaic virus'' (TMV) is a positive-sense single-stranded RNA virus species in the genus ''Tobamovirus'' that infects a wide range of plants, especially tobacco and other members of the family Solanaceae. The infection causes characteri ...

. In 1962 he moved to the newly built Medical Research Council (MRC)

Laboratory of Molecular Biology The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s. Since then it has remained a major medical r ...

(LMB) in Cambridge. Over the following decade Klug used methods from

X-ray diffraction X-ray crystallography is the experimental science determining the atomic and molecular structure of a crystal, in which the crystalline structure causes a beam of incident X-rays to diffract into many specific directions. By measuring the angles ...

, microscopy and structural modelling to develop crystallographic electron microscopy in which a sequence of two-dimensional images of crystals taken from different angles are combined to produce three-dimensional images of the target. He studied the structure of

transfer RNA Transfer RNA (abbreviated tRNA and formerly referred to as sRNA, for soluble RNA) is an adaptor molecule composed of RNA, typically 76 to 90 nucleotides in length (in eukaryotes), that serves as the physical link between the mRNA and the amino ...

, and found what is known as zinc fingers as well as the neurofibrils in Alzheimer's disease. Also in 1962 Klug had been offered a teaching Fellowship at

Peterhouse, Cambridge Peterhouse is the oldest constituent college of the University of Cambridge in England, founded in 1284 by Hugh de Balsham, Bishop of Ely. Today, Peterhouse has 254 undergraduates, 116 full-time graduate students and 54 fellows. It is quite ...

. After receiving the Nobel Prize in Chemistry in 1982, he went on teaching because he found the courses interesting and was later made an Honorary Fellow at the College. Between 1986 and 1996 he was director of the Laboratory of Molecular Biology in Cambridge. Klug served on the Advisory Council for the

Campaign for Science and Engineering The Campaign for Science and Engineering (CaSE) is a non-profit organisation that is the UK's leading independent advocate for science and engineering. It focuses on arguing for more research funding, promoting a high-tech and knowledge-based e ...

. He also served on the Board of Scientific Governors at

The Scripps Research Institute Scripps Research, previously known as The Scripps Research Institute (TSRI), is a nonprofit American medical research facility that focuses on research and education in the biomedical sciences. Headquartered in San Diego, California, the instit ...

. He and

Dai Rees David James Rees, (31 March 1913 – 15 November 1983) was one of the Britain's leading golfers either side of the Second World War. The winner of many prestigious tournaments in Britain, Europe and farther afield, Rees is best remembered as ...

approached the

Wellcome Trust The Wellcome Trust is a charitable foundation focused on health research based in London, in the United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of one of the predecessors of Glaxo ...

to found the

Wellcome Sanger Institute The Wellcome Sanger Institute, previously known as The Sanger Centre and Wellcome Trust Sanger Institute, is a non-profit British genomics and genetics research institute, primarily funded by the Wellcome Trust. It is located on the Wellcome Ge ...

, which was a key player in the

Human Genome Project The Human Genome Project (HGP) was an international scientific research project with the goal of determining the base pairs that make up human DNA, and of identifying, mapping and sequencing all of the genes of the human genome from both ...

Awards and honours

Klug was awarded the

Louisa Gross Horwitz Prize The Louisa Gross Horwitz Prize for Biology or Biochemistry is an annual prize awarded by Columbia University to a researcher or group of researchers who have made an outstanding contribution in basic research in the fields of biology or biochemis ...

from

Columbia University Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...

in 1981. He was

knighted A knight is a person granted an honorary title of knighthood by a head of state (including the Pope) or representative for service to the monarch, the church or the country, especially in a military capacity. Knighthood finds origins in the G ...

Elizabeth II Elizabeth II (Elizabeth Alexandra Mary; 21 April 1926 – 8 September 2022) was Queen of the United Kingdom and other Commonwealth realms from 6 February 1952 until her death in 2022. She was queen regnant of 32 sovereign states durin ...

in 1988. In 1969 he was elected a Fellow of the Royal Society (FRS), the oldest national scientific institution in the world. He was elected its President (PRS) from 1995 to 2000. He was appointed to the

Order of Merit The Order of Merit (french: link=no, Ordre du Mérite) is an order of merit for the Commonwealth realms, recognising distinguished service in the armed forces, science, art, literature, or for the promotion of culture. Established in 1902 by ...

in 1995 – as is customary for Presidents of the Royal Society. His certificate of election to the Royal Society reads: Klug was a member of the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, a ...

and the

American Philosophical Society The American Philosophical Society (APS), founded in 1743 in Philadelphia, is a scholarly organization that promotes knowledge in the sciences and humanities through research, professional meetings, publications, library resources, and communit ...

In 2000, Klug received the Golden Plate Award of the

American Academy of Achievement The American Academy of Achievement, colloquially known as the Academy of Achievement, is a non-profit educational organization that recognizes some of the highest achieving individuals in diverse fields and gives them the opportunity to meet ...

. In 2005, he was awarded South Africa's

Order of Mapungubwe The Order of Mapungubwe is South Africa's highest honour. It was instituted on 6 December 2002, and is granted by the President of South Africa, for achievements in the international arena which have served South Africa's interests. The order orig ...

(gold) for exceptional achievements in medical science. He was elected a

Fellow of the Academy of Medical Sciences Fellowship of the Academy of Medical Sciences (FMedSci) is an award for medical scientists who are judged by the UK Academy of Medical Sciences for the "excellence of their science, their contribution to medicine and society and the range of th ...

(FMedSci), also in 2005. In 2013, Israel's

Ben-Gurion University of the Negev Ben-Gurion University of the Negev (BGU) ( he, אוניברסיטת בן-גוריון בנגב, ''Universitat Ben-Guriyon baNegev'') is a public research university in Beersheba, Israel. Ben-Gurion University of the Negev has five campuses: the ...

dedicated their centre for structural biology in Klug's name, ''Aaron Klug Integrated Centre for Biomolecular Structure''. He, his family and the then-British Ambassador to Israel

Matthew Gould Matthew Steven Gould (born 20 August 1971) is a British civil servant who is CEO of NHSX, the body which oversees digital policy and programmes in NHS England. He was Ambassador to Israel (2010–15) and Director General for Digital and Medi ...

, were in attendance. Klug was associated with the university and the town of

Be'er Sheva Beersheba or Beer Sheva, officially Be'er-Sheva ( he, בְּאֵר שֶׁבַע, ''Bəʾēr Ševaʿ'', ; ar, بئر السبع, Biʾr as-Sabʿ, Well of the Oath or Well of the Seven), is the largest city in the Negev desert of southern Israel. ...

, having visited them numerous times.

Personal life

Klug married Liebe Bobrow in 1948. Though Klug had faced discrimination in South Africa, he remained religious and according to

Sydney Brenner Sydney Brenner (13 January 1927 – 5 April 2019) was a South African biologist. In 2002, he shared the Nobel Prize in Physiology or Medicine with H. Robert Horvitz and Sir John E. Sulston. Brenner made significant contributions to work ...

, he became more religious in his older age.Hargittai, Istva'n & Magdolna. 2006. ''Candid Science VI: More Conversations with Famous Scientists''. Imperial College Press, p. 33

References

External links

* *
The Papers of Sir Aaron Klug
held at

Churchill Archives Centre The Churchill Archives Centre (CAC) at Churchill College at the University of Cambridge is one of the largest repositories in the United Kingdom for the preservation and study of modern personal papers. It is best known for housing the papers of ...