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Human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by
infection An infection is the invasion of an organism's body tissues by disease-causing agents, their multiplication, and the reaction of host tissues to the infectious agents and the toxins they produce. An infectious disease, also known as a transmissib ...

infection
with the
human immunodeficiency virus The human immunodeficiency viruses (HIV) are two species of ''Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune ...

human immunodeficiency virus
(HIV), a
retrovirus A retrovirus is a type of virus that inserts a copy of its RNA genome into the DNA of a host cell that it invades, thus changing the genome of that cell. Once inside the host cell's cytoplasm, the virus uses its own reverse transcriptase enzyme ...

retrovirus
. Following initial infection a person may not notice any symptoms, or may experience a brief period of
influenza-like illness Influenza-like illness (ILI), also known as flu-like syndrome or flu-like symptoms, is a medical diagnosis of possible influenza or other illness causing a set of common symptoms. These include fever, shivering, chills, malaise, dry cough, loss of ...

influenza-like illness
. Typically, this is followed by a prolonged period with no symptoms. If the infection progresses, it interferes more with the
immune system The immune system is a network of biological processes that protects an organism from diseases. It detects and responds to a wide variety of pathogens, from viruses to parasitic worms, as well as cancer cells and objects such as wood splinters, d ...

immune system
, increasing the risk of developing common infections such as
tuberculosis Tuberculosis (TB) is an infectious disease usually caused by ''Mycobacterium tuberculosis'' (MTB) bacteria. Tuberculosis generally affects the lungs, but can also affect other parts of the body. Most infections show no symptoms, in which cas ...

tuberculosis
, as well as other
opportunistic infection An opportunistic infection is an infection caused by pathogens (bacteria, fungi, parasites or viruses) that take advantage of an opportunity not normally available. These opportunities can stem from a variety of sources, such as a weakened immune s ...

opportunistic infection
s, and
tumors A neoplasm () is a type of abnormal and excessive growth, called neoplasia, of tissue. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists in growing abnormally, even if the original trigger is rem ...

tumors
which are otherwise rare in people who have normal immune function. These late symptoms of infection are referred to as acquired immunodeficiency syndrome (AIDS). This stage is often also associated with . HIV is primarily by
unprotected sex Safe sex is sexual activity using methods or devices (such as condoms) to reduce the risk of transmitting or acquiring sexually transmitted infections (STIs), especially HIV. "Safe sex" is also sometimes referred to as safer sex or protected s ...

unprotected sex
(including
anal Anal may refer to: Related to the anus *related to the anus of animals ** Anal fin, in fish anatomy ** Anal vein, in insect anatomy ** Anal scale, in reptile anatomy *related to the human anus ** Anal sex, a type of sexual activity involving sti ...

anal
and
oral sex#REDIRECT Oral sex#REDIRECT Oral sex {{Redirect category shell|1= {{R from other capitalisation ...
{{Redirect category shell|1= {{R from other capitalisation ...

oral sex
), contaminated
blood transfusion Blood transfusion is the process of transferring blood products into one's circulation intravenously. Transfusions are used for various medical conditions to replace lost components of the blood. Early transfusions used whole blood, but modern med ...

blood transfusion
s,
hypodermic needle Luer-Lok_connector_on_right.html" style="text-decoration: none;"class="mw-redirect" title="colour code">Syringe on left, hypodermic needle with attached Luer-Lok_connector_on_right">colour_code">Syringe_on_left,_hypodermic_needle_with_attached ...

hypodermic needle
s, and
from mother to child
from mother to child
during
pregnancy Pregnancy, also known as gestation, is the time during which one or more offspring develops inside a woman. A multiple pregnancy involves more than one offspring, such as with twins. Pregnancy usually occurs by sexual intercourse, but can occu ...

pregnancy
, delivery, or breastfeeding. Some bodily fluids, such as saliva, sweat and tears, do not transmit the virus. Methods of prevention include
safe sex Safe sex is sexual activity using methods or devices (such as condoms) to reduce the risk of transmitting or acquiring sexually transmitted infections (STIs), especially HIV. "Safe sex" is also sometimes referred to as safer sex or protected s ...

safe sex
,
needle exchange program A needle and syringe programme (NSP), also known as needle exchange program (NEP), is a social service that allows injecting drug users (IDUs) to obtain hypodermic needles and associated paraphernalia at little or no cost. It is based on the phi ...

needle exchange program
s,
treating those who are infected
treating those who are infected
, as well as both
pre-
pre-
and
post-exposure prophylaxis Post-exposure prophylaxis, also known as post-exposure prevention (PEP), is any preventive medical treatment started after exposure to a pathogen in order to prevent the infection from occurring. Rabies PEP is commonly and very effectively used t ...

post-exposure prophylaxis
. Disease in a baby can often be prevented by giving both the mother and child
antiretroviral medication The management of HIV/AIDS normally includes the use of multiple antiretroviral drugs in an attempt to control HIV infection. There are several classes of antiretroviral agents that act on different stages of the HIV life-cycle. The use of multiple ...

antiretroviral medication
. There is no cure or
vaccine A vaccine is a biological preparation that provides active acquired immunity to a particular infectious disease. A vaccine typically contains an agent that resembles a disease-causing microorganism and is often made from weakened or killed forms ...

vaccine
; however, antiretroviral treatment can slow the course of the disease and may lead to a near-normal life expectancy. Treatment is recommended as soon as the diagnosis is made. Without treatment, the average survival time after infection is 11 years. In 2019, about 38 million people worldwide were living with HIV and 690,000 deaths had occurred in that year. An estimated 20.6 million of these live in eastern and southern Africa. Between the time that AIDS was identified (in the early 1980s) and 2019, the disease has caused an estimated 32.7 million deaths worldwide. HIV/AIDS is considered a
pandemic A pandemic (from Greek , , "all" and , , "local people" the 'crowd') is an epidemic of an infectious disease that has spread across a large region, for instance multiple continents or worldwide, affecting a substantial number of people. A widespr ...

pandemic
—a disease outbreak which is present over a large area and is actively spreading.(subscription required) HIV made the jump from other primates to humans in west-central Africa in the early-to-mid 20th century. AIDS was by the United States
Centers for Disease Control and Prevention The United States Centers for Disease Control and Prevention (CDC or U.S. CDC) is the national public health agency of the United States. It is a United States federal agency, under the Department of Health and Human Services, and is headquarte ...

Centers for Disease Control and Prevention
(CDC) in 1981 and its cause—HIV infection—was identified in the early part of the decade. HIV/AIDS has had a large impact on society, both as an illness and as a source of
discrimination Discrimination is the act of making unjustified distinctions between human beings based on the groups, classes, or other categories to which they are perceived to belong. People may be discriminated on the basis of race, gender, age, religion, o ...

discrimination
. The disease also has large . There are many , such as the belief that it can be transmitted by casual non-sexual contact. The disease has become subject to many , including the not to support
condom A condom is a sheath-shaped barrier device used during sexual intercourse to reduce the probability of pregnancy or a sexually transmitted infection (STI). There are both male and female condoms. With proper use—and use at every act of interc ...

condom
use as prevention. It has attracted international medical and political attention as well as large-scale funding since it was identified in the 1980s.


Signs and symptoms

There are three main stages of
HIV The human immunodeficiency viruses (HIV) are two species of ''Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune ...

HIV
infection: acute infection, clinical latency, and AIDS.Mandell, Bennett, and Dolan (2010). Chapter 121.


Acute infection

The initial period following the contraction of HIV is called acute HIV, primary HIV or acute retroviral syndrome. Many individuals develop an
influenza-like illness Influenza-like illness (ILI), also known as flu-like syndrome or flu-like symptoms, is a medical diagnosis of possible influenza or other illness causing a set of common symptoms. These include fever, shivering, chills, malaise, dry cough, loss of ...

influenza-like illness
or a 2–4 weeks after exposure while others have no significant symptoms. Symptoms occur in 40–90% of cases and most commonly include
fever Fever, also referred to as pyrexia, is defined as having a temperature above the normal range due to an increase in the body's temperature set point. There is not a single agreed-upon upper limit for normal temperature with sources using values ...

fever
, , , a
rash A rash is a change of the human skin which affects its color, appearance, or texture. A rash may be localized in one part of the body, or affect all the skin. Rashes may cause the skin to change color, itch, become warm, bumpy, chapped, dry, crac ...

rash
, headache, tiredness, and/or sores of the mouth and genitals. The rash, which occurs in 20–50% of cases, presents itself on the trunk and is
maculopapular A maculopapular rash is a type of rash characterized by a flat, red area on the skin that is covered with small confluent bumps. It may only appear red in lighter-skinned people. The term "maculopapular" is a compound: ''macules'' are small, flat di ...

maculopapular
, classically. Some people also develop
opportunistic infections An opportunistic infection is an infection caused by pathogens (bacteria, fungi, parasites or viruses) that take advantage of an opportunity not normally available. These opportunities can stem from a variety of sources, such as a weakened immune s ...

opportunistic infections
at this stage. Gastrointestinal symptoms, such as vomiting or
diarrhea Diarrhea, also spelled diarrhoea, is the condition of having at least three loose, liquid, or watery bowel movements each day. It often lasts for a few days and can result in dehydration due to fluid loss. Signs of dehydration often begin wit ...

diarrhea
may occur. Neurological symptoms of
peripheral neuropathy Peripheral neuropathy, often shortened to neuropathy, is a general term describing disease affecting the peripheral nerves, meaning nerves beyond the brain and spinal cord. Damage to peripheral nerves may impair sensation, movement, gland or orga ...

peripheral neuropathy
or
Guillain–Barré syndrome Guillain–Barré syndrome (GBS) is a rapid-onset muscle weakness caused by the immune system damaging the peripheral nervous system. Typically, both sides of the body are involved, and the initial symptoms are changes in sensation or pain often ...

Guillain–Barré syndrome
also occurs. The duration of the symptoms varies, but is usually one or two weeks. Owing to their character, these symptoms are not often as signs of HIV infection. Even cases that do get seen by a family doctor or a hospital are often misdiagnosed as one of the many common
infectious disease An infection is the invasion of an organism's body tissues by disease-causing agents, their multiplication, and the reaction of host tissues to the infectious agents and the toxins they produce. An infectious disease, also known as a transmissib ...

infectious disease
s with overlapping symptoms. Thus, it is recommended that HIV be considered in people presenting with an who may have risk factors for the infection.Mandell, Bennett, and Dolan (2010). Chapter 118.


Clinical latency

The initial symptoms are followed by a stage called clinical latency, asymptomatic HIV, or chronic HIV. Without treatment, this second stage of the
natural history Natural history is a domain of inquiry involving organisms, including animals, fungi, and plants, in their natural environment, leaning more towards observational than experimental methods of study. A person who studies natural history is calle ...

natural history
of HIV infection can last from about three years to over 20 years (on average, about eight years). While typically there are few or no symptoms at first, near the end of this stage many people experience fever, weight loss, gastrointestinal problems and muscle pains. Between 50% and 70% of people also develop
persistent generalized lymphadenopathyPersistent generalized lymphadenopathy (PGL) is enlarged, painless, non-tender lymph nodes occurring in a couple of different areas for more than three to six months for which no other reason can be found. This condition occurs frequently in people i ...

persistent generalized lymphadenopathy
, characterized by unexplained, non-painful enlargement of more than one group of lymph nodes (other than in the groin) for over three to six months. Although most
HIV-1 One of the obstacles to treatment of the human immunodeficiency virus (HIV) is its high genetic variability. HIV can be divided into two major types, HIV type 1 (HIV-1) and HIV type 2 (HIV-2). HIV-1 is related to viruses found in chimpanzees and g ...

HIV-1
infected individuals have a detectable viral load and in the absence of treatment will eventually progress to AIDS, a small proportion (about 5%) retain high levels of CD4+ T cells (
T helper cell The T helper cells (Th cells), also known as CD4+ cells or CD4-positive cells, are a type of T cell that play an important role in the immune system, particularly in the adaptive immune system. As their name suggests, they "help" the activity of ...

T helper cell
s) without
antiretroviral therapy The management of HIV/AIDS normally includes the use of multiple antiretroviral drugs in an attempt to control HIV infection. There are several classes of antiretroviral agents that act on different stages of the HIV life-cycle. The use of multiple ...

antiretroviral therapy
for more than five years. These individuals are classified as "HIV controllers" or (LTNP). Another group consists of those who maintain a low or undetectable viral load without anti-retroviral treatment, known as "elite controllers" or "elite suppressors". They represent approximately 1 in 300 infected persons.


Acquired immunodeficiency syndrome

Acquired immunodeficiency syndrome (AIDS) is defined as an HIV infection with either a CD4+ T cell count below 200 cells per µL or the occurrence of specific diseases associated with HIV infection. In the absence of specific treatment, around half of people infected with HIV develop AIDS within ten years. The most common initial conditions that alert to the presence of AIDS are
pneumocystis pneumonia ''Pneumocystis'' pneumonia (PCP) is a form of pneumonia that is caused by the yeast-like fungus ''Pneumocystis jirovecii''. It is also known as PJP, for Pneumocystis jiroveci Pneumonia. ''Pneumocystis'' specimens are commonly found in the lungs o ...

pneumocystis pneumonia
(40%),
cachexia Cachexia () is a complex syndrome associated with an underlying illness causing ongoing muscle loss that is not entirely reversed with nutritional supplementation. A range of diseases can cause cachexia, most commonly cancer, congestive heart failu ...

cachexia
in the form of HIV wasting syndrome (20%), and . Other common signs include recurrent
respiratory tract infection Respiratory tract infections (RTIs) are infectious diseases involving the respiratory tract. An infection of this type usually is further classified as an upper respiratory tract infection (URI or URTI) or a lower respiratory tract infection (LRI o ...

respiratory tract infection
s.
Opportunistic infections An opportunistic infection is an infection caused by pathogens (bacteria, fungi, parasites or viruses) that take advantage of an opportunity not normally available. These opportunities can stem from a variety of sources, such as a weakened immune s ...

Opportunistic infections
may be caused by
bacteria Bacteria (; common noun bacteria, singular bacterium) are a type of biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria have a number of shapes, ranging from spheres ...

bacteria
,
virus A virus is a submicroscopic infectious agent that replicates only inside the living cells of an organism. Viruses infect all types of life forms, from animals and plants to microorganisms, including bacteria and archaea. Since Dmitri Ivanovs ...

virus
es,
fungi A fungus (plural: fungi or funguses) is any member of the group of eukaryotic organisms that includes microorganisms such as yeasts and molds, as well as the more familiar mushrooms. These organisms are classified as a kingdom, which is separa ...

fungi
, and
parasite Parasitism is a symbiotic relationship between species, where one organism, the parasite, lives on or inside another organism, the host, causing it some harm, and is adapted structurally to this way of life. The entomologist E. O. Wilson has ...

parasite
s that are normally controlled by the immune system. Which infections occur depends partly on what organisms are common in the person's environment. These infections may affect nearly every
organ system An organ system is a group of organs that work together as a biological system to perform one or more functions. Each organ does a particular job in the body, and is made up of distinct tissues. Organ systems and their functions There are 11 dis ...

organ system
. People with AIDS have an increased risk of developing various viral-induced cancers, including
Kaposi's sarcoma Kaposi's sarcoma (KS) is a type of cancer that can form masses in the skin, lymph nodes, or other organs. The skin lesions are usually purple in color. They can occur singly or in a limited area, or may be widespread. It may worsen either graduall ...

Kaposi's sarcoma
,
Burkitt's lymphoma Burkitt lymphoma is a cancer of the lymphatic system, particularly B lymphocytes found in the germinal center. It is named after Denis Parsons Burkitt, the Irish surgeon who first described the disease in 1958 while working in equatorial Africa. Th ...

Burkitt's lymphoma
, , and
cervical cancer Cervical cancer is a cancer arising from the cervix. It is due to the abnormal growth of cells that have the ability to invade or spread to other parts of the body. Early on, typically no symptoms are seen. Later symptoms may include abnormal vagi ...

cervical cancer
. Kaposi's sarcoma is the most common cancer, occurring in 10% to 20% of people with HIV.Mandell, Bennett, and Dolan (2010). Chapter 169. The second-most common cancer is lymphoma, which is the cause of death of nearly 16% of people with AIDS and is the initial sign of AIDS in 3% to 4%. Both these cancers are associated with
human herpesvirus 8 Kaposi's sarcoma-associated herpesvirus (KSHV) is the ninth known human herpesvirus; its formal name according to the International Committee on Taxonomy of Viruses (ICTV) is ''Human gammaherpesvirus 8'', or HHV-8 in short. Like other herpesviruse ...

human herpesvirus 8
(HHV-8). Cervical cancer occurs more frequently in those with AIDS because of its association with
human papillomavirus Human papillomavirus infection (HPV infection) is an infection caused by ''human papillomavirus'' (HPV), a DNA virus from the ''Papillomaviridae'' family. Many HPV infections cause no symptoms and 90% resolve spontaneously within two years. Howe ...

human papillomavirus
(HPV). (of the layer that lines the inner part of eyelids and the white part of the eye) is also more common in those with HIV. Additionally, people with AIDS frequently have systemic symptoms such as prolonged fevers, (particularly at night), swollen lymph nodes, chills, weakness, and . Diarrhea is another common symptom, present in about 90% of people with AIDS. They can also be affected by diverse psychiatric and neurological symptoms independent of opportunistic infections and cancers.


Transmission

HIV is spread by three main routes:
sexual contact Human sexual activity, human sexual practice or human sexual behaviour is the manner in which humans experience and express their sexuality. People engage in a variety of sexual acts, ranging from activities done alone (e.g., masturbation) to ...

sexual contact
, significant exposure to infected body fluids or tissues, and from mother to child during pregnancy, delivery, or breastfeeding (known as
vertical transmissionVertical transmission of symbionts is the transfer of a microbial symbiont from the parent directly to the offspring.  Many metazoan species carry symbiotic bacteria which play a mutualistic, commensal, or parasitic role.  A symbiont is acquired by ...

vertical transmission
). There is no risk of acquiring HIV if exposed to
feces Feces (or faeces) is the solid or semisolid remains of food that was not digested in the small intestine, and has been broken down by bacteria in the large intestine. Feces contains a relatively small amount of metabolic waste products such as ...

feces
, nasal secretions, saliva,
sputum Sputum is mucus that is coughed up from the lower airways (the trachea and bronchi). In medicine, sputum samples are usually used for naked eye exam, microbiological investigations of respiratory infections and cytological investigations of resp ...

sputum
, sweat, tears, urine, or vomit unless these are contaminated with blood. It is also possible to be by more than one strain of HIV—a condition known as
HIV superinfectionHIV superinfection (also called HIV reinfection or SuperAIDS) is a condition in which a person with an established human immunodeficiency virus infection acquires a second strain of HIV, often of a different subtype. These can form a recombinant stra ...

HIV superinfection
.


Sexual

The most frequent mode of transmission of HIV is through sexual contact with an infected person. However, an HIV-positive person who has an undetectable viral load as a result of long-term treatment has effectively no risk of transmitting HIV sexually. The existence of functionally noncontagious HIV-positive people on antiretroviral therapy was controversially publicized in the 2008
Swiss Statement The Swiss Statement (French: ''La déclaration suisse''; known in German as ''das EKAF-Statement''), or the Swiss Consensus Statement, was an announcement published in January 2008 by the Swiss Federal Commission for AIDS/HIV (EKAF, ''Eidgenössisch ...

Swiss Statement
, and has since become accepted as medically sound. Globally, the most common mode of HIV transmission is via ; however, the pattern of transmission varies among countries. , most HIV transmission in the United States occurred among (82% of new HIV diagnoses among males aged 13 and older and 70% of total new diagnoses). In the US, gay and bisexual men aged 13 to 24 accounted for an estimated 92% of new HIV diagnoses among all men in their age group and 27% of new diagnoses among all gay and bisexual men. With regard to [[unprotected sex|unprotected heterosexual contacts, estimates of the risk of HIV transmission per sexual act appear to be four to ten times higher in low-income countries than in high-income countries. In low-income countries, the risk of female-to-male transmission is estimated as 0.38% per act, and of male-to-female transmission as 0.30% per act; the equivalent estimates for high-income countries are 0.04% per act for female-to-male transmission, and 0.08% per act for male-to-female transmission. The risk of transmission from anal intercourse is especially high, estimated as 1.4–1.7% per act in both heterosexual and homosexual contacts. While the risk of transmission from
oral sex#REDIRECT Oral sex#REDIRECT Oral sex {{Redirect category shell|1= {{R from other capitalisation ...
{{Redirect category shell|1= {{R from other capitalisation ...

oral sex is relatively low, it is still present. The risk from receiving oral sex has been described as "nearly nil"; however, a few cases have been reported. The per-act risk is estimated at 0–0.04% for receptive oral intercourse. In settings involving [[prostitution in low-income countries, risk of female-to-male transmission has been estimated as 2.4% per act, and of male-to-female transmission as 0.05% per act. Risk of transmission increases in the presence of many [[sexually transmitted infections and [[genital ulcers. Genital ulcers appear to increase the risk approximately fivefold. Other sexually transmitted infections, such as [[gonorrhea, [[Chlamydia infection|chlamydia, [[trichomoniasis, and [[bacterial vaginosis, are associated with somewhat smaller increases in risk of transmission. The [[viral load of an infected person is an important risk factor in both sexual and mother-to-child transmission. During the first 2.5 months of an HIV infection a person's infectiousness is twelve times higher due to the high viral load associated with acute HIV. If the person is in the late stages of infection, rates of transmission are approximately eightfold greater. Commercial sex workers (including [[HIV/AIDS in the pornographic film industry|those in pornography) have an increased likelihood of contracting HIV. Rough sex can be a factor associated with an increased risk of transmission. [[Sexual assault is also believed to carry an increased risk of HIV transmission as condoms are rarely worn, physical trauma to the vagina or rectum is likely, and there may be a greater risk of concurrent sexually transmitted infections.


Body fluids

The second-most frequent mode of HIV transmission is via blood and blood products. Blood-borne transmission can be through needle-sharing during intravenous drug use, needle-stick injury, transfusion of contaminated blood or blood product, or medical injections with unsterilized equipment. The risk from sharing a needle during [[drug injection is between 0.63% and 2.4% per act, with an average of 0.8%. The risk of acquiring HIV from a needle stick from an HIV-infected person is estimated as 0.3% (about 1 in 333) per act and the risk following [[mucous membrane exposure to infected blood as 0.09% (about 1 in 1000) per act. This risk may, however, be up to 5% if the introduced blood was from a person with a high viral load and the cut was deep. In the United States intravenous drug users made up 12% of all new cases of HIV in 2009, and in some areas more than 80% of people who inject drugs are HIV-positive. HIV is transmitted in about 90% of
blood transfusion Blood transfusion is the process of transferring blood products into one's circulation intravenously. Transfusions are used for various medical conditions to replace lost components of the blood. Early transfusions used whole blood, but modern med ...

blood transfusion
s using infected blood. In developed countries the risk of acquiring HIV from a blood transfusion is extremely low (less than one in half a million) where improved donor selection and [[HIV screening is performed; for example, in the UK the risk is reported at one in five million and in the United States it was one in 1.5 million in 2008. In low-income countries, only half of transfusions may be appropriately screened (as of 2008),UNAIDS 2011 pg. 60–70 and it is estimated that up to 15% of HIV infections in these areas come from transfusion of infected blood and blood products, representing between 5% and 10% of global infections. It is possible to acquire HIV from organ and tissue [[Organ transplantation|transplantation, although this is rare because of [[HIV screening|screening. Unsafe medical injections play a role in [[HIV/AIDS in Africa|HIV spread in sub-Saharan Africa. In 2007, between 12% and 17% of infections in this region were attributed to medical syringe use. The [[World Health Organization estimates the risk of transmission as a result of a medical injection in Africa at 1.2%. Risks are also associated with invasive procedures, assisted delivery, and dental care in this area of the world. People giving or receiving [[tattoos, [[body piercing|piercings, and [[scarification are theoretically at risk of infection but no confirmed cases have been documented. It is not possible for [[mosquitoes or other insects to transmit HIV.


Mother-to-child

HIV can be transmitted from mother to child during pregnancy, during delivery, or through breast milk, resulting in the baby also contracting HIV. As of 2008, vertical transmission accounted for about 90% of cases of HIV in children. In the absence of treatment, the risk of transmission before or during birth is around 20%, and in those who also breastfeed 35%. Treatment decreases this risk to less than 5%. Antiretrovirals when taken by either the mother or the baby decrease the risk of transmission in those who do breastfeed. If blood contaminates food during [[Premastication|pre-chewing it may pose a risk of transmission. If a woman is untreated, two years of breastfeeding results in an HIV/AIDS risk in her baby of about 17%. Due to the increased risk of death without breastfeeding in many areas in the developing world, the World Health Organization recommends either exclusive breastfeeding or the provision of safe formula. All women known to be HIV-positive should be taking lifelong antiretroviral therapy.


Virology

[[HIV is the cause of the spectrum of disease known as HIV/AIDS. HIV is a
retrovirus A retrovirus is a type of virus that inserts a copy of its RNA genome into the DNA of a host cell that it invades, thus changing the genome of that cell. Once inside the host cell's cytoplasm, the virus uses its own reverse transcriptase enzyme ...

retrovirus
that primarily infects components of the human
immune system The immune system is a network of biological processes that protects an organism from diseases. It detects and responds to a wide variety of pathogens, from viruses to parasitic worms, as well as cancer cells and objects such as wood splinters, d ...

immune system
such as CD4+ T cells, [[macrophages and [[dendritic cells. It directly and indirectly destroys CD4+ T cells. HIV is a member of the [[genus ''[[Lentivirus'', part of the family ''[[Retroviridae''. Lentiviruses share many [[morphology (biology)|morphological and [[biology|biological characteristics. Many species of mammals are infected by lentiviruses, which are characteristically responsible for long-duration illnesses with a long [[incubation period. Lentiviruses are transmitted as single-stranded, positive-[[Sense (molecular biology)|sense, enveloped [[RNA viruses. Upon entry into the target cell, the viral [[RNA [[genome is converted (reverse transcribed) into double-stranded [[DNA by a virally encoded [[reverse transcriptase that is transported along with the viral genome in the virus particle. The resulting viral DNA is then imported into the cell nucleus and integrated into the cellular DNA by a virally encoded [[integrase and host co-factors. Once integrated, the virus may become [[Incubation period|latent, allowing the virus and its host cell to avoid detection by the immune system. Alternatively, the virus may be [[Transcription (genetics)|transcribed, producing new RNA genomes and viral proteins that are packaged and released from the cell as new virus particles that begin the replication cycle anew. HIV is now known to spread between CD4+ T cells by two parallel routes: cell-free spread and cell-to-cell spread, i.e. it employs hybrid spreading mechanisms. In the cell-free spread, virus particles bud from an infected T cell, enter the blood/extracellular fluid and then infect another T cell following a chance encounter. HIV can also disseminate by direct transmission from one cell to another by a process of cell-to-cell spread. The hybrid spreading mechanisms of HIV contribute to the virus's ongoing replication against antiretroviral therapies. Two [[Subtypes of HIV|types of HIV have been characterized: HIV-1 and HIV-2. HIV-1 is the virus that was originally discovered (and initially referred to also as LAV or HTLV-III). It is more [[virulence|virulent, more [[infectivity|infective, and is the cause of the majority of HIV infections globally. The lower infectivity of HIV-2 as compared with HIV-1 implies that fewer people exposed to HIV-2 will be infected per exposure. Because of its relatively poor capacity for transmission, HIV-2 is largely confined to [[West Africa.


Pathophysiology

[[File:Hiv replication cycle.gif|upright=1.4|HIV replication cycle After the virus enters the body there is a period of rapid [[viral replication, leading to an abundance of virus in the peripheral blood. During primary infection, the level of HIV may reach several million virus particles per milliliter of blood. This response is accompanied by a marked drop in the number of circulating [[T helper cell|CD4+ T cells. The acute [[viremia is almost invariably associated with activation of [[cytotoxic T cell|CD8+ T cells, which kill HIV-infected cells, and subsequently with antibody production, or [[seroconversion. The CD8+ T cell response is thought to be important in controlling virus levels, which peak and then decline, as the CD4+ T cell counts recover. A good CD8+ T cell response has been linked to slower disease progression and a better prognosis, though it does not eliminate the virus. Ultimately, HIV causes AIDS by depleting CD4+ T cells. This weakens the immune system and allows
opportunistic infection An opportunistic infection is an infection caused by pathogens (bacteria, fungi, parasites or viruses) that take advantage of an opportunity not normally available. These opportunities can stem from a variety of sources, such as a weakened immune s ...

opportunistic infection
s. T cells are essential to the immune response and without them, the body cannot fight infections or kill cancerous cells. The mechanism of CD4+ T cell depletion differs in the acute and chronic phases. During the acute phase, HIV-induced cell lysis and killing of infected cells by CD8+ T cells accounts for CD4+ T cell depletion, although [[apoptosis may also be a factor. During the chronic phase, the consequences of generalized immune activation coupled with the gradual loss of the ability of the immune system to generate new T cells appear to account for the slow decline in CD4+ T cell numbers. Although the symptoms of immune deficiency characteristic of AIDS do not appear for years after a person is infected, the bulk of CD4+ T cell loss occurs during the first weeks of infection, especially in the intestinal mucosa, which harbors the majority of the lymphocytes found in the body. The reason for the preferential loss of mucosal CD4+ T cells is that the majority of mucosal CD4+ T cells express the [[CCR5 protein which HIV uses as a [[co-receptor to gain access to the cells, whereas only a small fraction of CD4+ T cells in the bloodstream do so. A [[CCR5#CCR5-Δ32|specific genetic change that alters the CCR5 protein when present in both [[chromosomes very effectively prevents HIV-1 infection. HIV seeks out and destroys CCR5 expressing CD4+ T cells during acute infection. A vigorous immune response eventually controls the infection and initiates the clinically latent phase. CD4+ T cells in mucosal tissues remain particularly affected. Continuous HIV replication causes a state of generalized immune activation persisting throughout the chronic phase. Immune activation, which is reflected by the increased activation state of immune cells and release of pro-inflammatory [[cytokines, results from the activity of several HIV [[gene products and the immune response to ongoing HIV replication. It is also linked to the breakdown of the immune surveillance system of the gastrointestinal mucosal barrier caused by the depletion of mucosal CD4+ T cells during the acute phase of disease.


Diagnosis

HIV/AIDS is diagnosed via laboratory testing and then staged based on the presence of [[AIDS defining clinical condition|certain signs or symptoms. HIV screening is recommended by the [[United States Preventive Services Task Force for all people 15 years to 65 years of age, including all pregnant women. Additionally, testing is recommended for those at high risk, which includes anyone diagnosed with a sexually transmitted illness. In many areas of the world, a third of HIV carriers only discover they are infected at an advanced stage of the disease when AIDS or severe immunodeficiency has become apparent.


HIV testing

Most people infected with HIV develop specific [[antibodies (i.e. [[seroconversion|seroconvert) within three to twelve weeks after the initial infection. Diagnosis of primary HIV before seroconversion is done by measuring HIV-[[RNA or [[P24 antigen#Antigen tests|p24 antigen. Positive results obtained by antibody or [[Polymerase chain reaction|PCR testing are confirmed either by a different antibody or by PCR. Antibody tests in children younger than 18 months are typically inaccurate, due to the continued presence of [[Maternal Passive Immunity#Naturally acquired passive immunity|maternal antibodies. Thus HIV infection can only be diagnosed by PCR testing for HIV RNA or DNA, or via testing for the p24 antigen. Much of the world lacks access to reliable PCR testing, and people in many places simply wait until either symptoms develop or the child is old enough for accurate antibody testing. In sub-Saharan Africa between 2007 and 2009, between 30% and 70% of the population were aware of their HIV status.UNAIDS 2011 pg. 70–80 In 2009, between 3.6% and 42% of men and women in sub-Saharan countries were tested; this represented a significant increase compared to previous years.


Classifications

Two main clinical staging systems are used to classify HIV and HIV-related disease for [[Disease surveillance|surveillance purposes: the [[WHO disease staging system for HIV infection and disease, and the [[CDC classification system for HIV infection. The CDC's classification system is more frequently adopted in developed countries. Since the WHO's staging system does not require laboratory tests, it is suited to the resource-restricted conditions encountered in developing countries, where it can also be used to help guide clinical management. Despite their differences, the two systems allow comparison for statistical purposes. The World Health Organization first proposed a definition for AIDS in 1986. Since then, the WHO classification has been updated and expanded several times, with the most recent version being published in 2007. The WHO system uses the following categories: * Primary HIV infection: May be either asymptomatic or associated with acute retroviral syndrome * Stage I: HIV infection is [[asymptomatic with a CD4+ T cell count (also known as CD4 count) greater than 500 per microlitre (µl or cubic mm) of blood. May include generalized lymph node enlargement. * Stage II: Mild symptoms, which may include minor [[Mucous membrane|mucocutaneous manifestations and recurrent [[upper respiratory tract infections. A CD4 count of less than 500/µl * Stage III: Advanced symptoms, which may include unexplained [[Chronic (medical)|chronic diarrhea for longer than a month, severe bacterial infections including tuberculosis of the lung, and a CD4 count of less than 350/µl * Stage IV or AIDS: severe symptoms, which include [[toxoplasmosis of the brain, [[candidiasis of the [[esophagus, [[Vertebrate trachea|trachea, [[bronchus|bronchi, or [[lungs, and
Kaposi's sarcoma Kaposi's sarcoma (KS) is a type of cancer that can form masses in the skin, lymph nodes, or other organs. The skin lesions are usually purple in color. They can occur singly or in a limited area, or may be widespread. It may worsen either graduall ...

Kaposi's sarcoma
. A CD4 count of less than 200/µl The United States Center for Disease Control and Prevention also created a classification system for HIV, and updated it in 2008 and 2014. This system classifies HIV infections based on CD4 count and clinical symptoms, and describes the infection in five groups. In those greater than six years of age it is: * Stage 0: the time between a negative or indeterminate HIV test followed less than 180 days by a positive test. * Stage 1: CD4 count ≥ 500 cells/µl and no AIDS-defining conditions. * Stage 2: CD4 count 200 to 500 cells/µl and no AIDS-defining conditions. * Stage 3: CD4 count ≤ 200 cells/µl or AIDS-defining conditions. * Unknown: if insufficient information is available to make any of the above classifications. For surveillance purposes, the AIDS diagnosis still stands even if, after treatment, the CD4+ T cell count rises to above 200 per µL of blood or other AIDS-defining illnesses are cured.


Prevention


Sexual contact

Consistent
condom A condom is a sheath-shaped barrier device used during sexual intercourse to reduce the probability of pregnancy or a sexually transmitted infection (STI). There are both male and female condoms. With proper use—and use at every act of interc ...

condom
use reduces the risk of HIV transmission by approximately 80% over the long term. When condoms are used consistently by a couple in which one person is infected, the rate of HIV infection is less than 1% per year. There is some evidence to suggest that [[female condoms may provide an equivalent level of protection. Application of a vaginal gel containing [[tenofovir (a [[reverse transcriptase inhibitor) immediately before sex seems to reduce infection rates by approximately 40% among African women. By contrast, use of the [[spermicide [[nonoxynol-9 may increase the risk of transmission due to its tendency to cause vaginal and rectal irritation. [[Circumcision in [[Sub-Saharan Africa "reduces the acquisition of HIV by heterosexual men by between 38% and 66% over 24 months". Owing to these studies, both the World Health Organization and [[UNAIDS recommended male circumcision in 2007 as a method of preventing female-to-male HIV transmission in areas with high rates of HIV. However, whether it protects against male-to-female transmission is disputed,(subscription required) and whether it is of benefit in [[developed countries and among [[men who have sex with men is undetermined. Programs encouraging [[Abstinence-only sex education|sexual abstinence do not appear to affect subsequent HIV risk. Evidence of any benefit from [[peer education is equally poor. Comprehensive [[Sex education|sexual education provided at school may decrease high-risk behavior. A substantial minority of young people continues to engage in high-risk practices despite knowing about HIV/AIDS, underestimating their own risk of becoming infected with HIV. Voluntary counseling and testing people for HIV does not affect risky behavior in those who test negative but does increase condom use in those who test positive. Enhanced family planning services appear to increase the likelihood of women with HIV using contraception, compared to basic services. It is not known whether treating other sexually transmitted infections is effective in preventing HIV.


Pre-exposure

Antiretroviral treatment among people with HIV whose CD4 count ≤ 550 cells/µL is a very effective way to prevent HIV infection of their partner (a strategy known as treatment as prevention, or TASP). TASP is associated with a 10- to 20-fold reduction in transmission risk. [[Pre-exposure prophylaxis (PrEP) with a daily dose of the medications [[tenofovir, with or without [[emtricitabine, is effective in people at high risk including men who have sex with men, couples where one is HIV-positive, and young heterosexuals in Africa. It may also be effective in intravenous drug users, with a study finding a decrease in risk of 0.7 to 0.4 per 100 person years. The [[USPSTF, in 2019, recommended PrEP in those who are at high risk. [[Universal precautions within the health care environment are believed to be effective in decreasing the risk of HIV. [[Intravenous drug use is an important risk factor, and [[harm reduction strategies such as [[needle-exchange programs and [[Opioid replacement therapy|opioid substitution therapy appear effective in decreasing this risk.


Post-exposure

A course of antiretrovirals administered within 48 to 72 hours after exposure to HIV-positive blood or genital secretions is referred to as
post-exposure prophylaxis Post-exposure prophylaxis, also known as post-exposure prevention (PEP), is any preventive medical treatment started after exposure to a pathogen in order to prevent the infection from occurring. Rabies PEP is commonly and very effectively used t ...

post-exposure prophylaxis
(PEP). The use of the single agent [[zidovudine reduces the risk of a HIV infection five-fold following a needle-stick injury. , the prevention regimen recommended in the United States consists of three medications—[[tenofovir, [[emtricitabine and [[raltegravir—as this may reduce the risk further. PEP treatment is recommended after a [[sexual assault when the perpetrator is known to be HIV-positive, but is controversial when their HIV status is unknown. The duration of treatment is usually four weeks and is frequently associated with adverse effects—where zidovudine is used, about 70% of cases result in adverse effects such as nausea (24%), fatigue (22%), emotional distress (13%) and headaches (9%).


Mother-to-child

Programs to prevent the
vertical transmissionVertical transmission of symbionts is the transfer of a microbial symbiont from the parent directly to the offspring.  Many metazoan species carry symbiotic bacteria which play a mutualistic, commensal, or parasitic role.  A symbiont is acquired by ...

vertical transmission
of HIV (from mothers to children) can reduce rates of transmission by 92–99%. This primarily involves the use of a combination of antiviral medications during pregnancy and after birth in the infant, and potentially includes [[bottle feeding rather than [[breastfeeding. If replacement feeding is acceptable, feasible, affordable, sustainable and safe, mothers should avoid breastfeeding their infants; however, exclusive breastfeeding is recommended during the first months of life if this is not the case. If exclusive breastfeeding is carried out, the provision of extended antiretroviral prophylaxis to the infant decreases the risk of transmission. In 2015, [[Cuba became the first country in the world to eradicate mother-to-child transmission of HIV.


Vaccination

Currently there is no licensed [[HIV vaccine|vaccine for HIV or AIDS. The most effective vaccine trial to date, [[RV 144, was published in 2009; it found a partial reduction in the risk of transmission of roughly 30%, stimulating some hope in the research community of developing a truly effective vaccine. Further trials of the RV 144 vaccine are ongoing.


Treatment

There is currently no cure, nor an effective HIV vaccine. Treatment consists of highly active antiretroviral therapy (HAART) which slows progression of the disease. more than 6.6 million people were receiving this in low- and middle-income countries.UNAIDS 2011 pg. 1–10 Treatment also includes preventive and active treatment of opportunistic infections. , two persons have been successfully cleared of HIV. Rapid initiation of anti-retroviral therapy within one week of diagnosis appear to improve treatment outcomes in low and medium-income settings.


Antiviral therapy

Current HAART options are combinations (or "cocktails") consisting of at least three medications belonging to at least two types, or "classes", of [[antiretroviral agents. Initially, treatment is typically a [[non-nucleoside reverse transcriptase inhibitor (NNRTI) plus two [[nucleoside analogue reverse transcriptase inhibitor|nucleoside analog reverse transcriptase inhibitors (NRTIs). Typical NRTIs include: [[zidovudine (AZT) or [[tenofovir (TDF) and [[lamivudine (3TC) or [[emtricitabine (FTC). As of 2019, [[dolutegravir/lamivudine/tenofovir is listed by the [[World Health Organization as the first-line treatment for adults, with [[tenofovir/lamivudine/efavirenz as an alternative. Combinations of agents that include [[protease inhibitor (pharmacology)|protease inhibitors (PI) are used if the above regimen loses effectiveness. The World Health Organization and the United States recommend antiretrovirals in people of all ages (including pregnant women) as soon as the diagnosis is made, regardless of CD4 count. Once treatment is begun, it is recommended that it is continued without breaks or "holidays". Many people are diagnosed only after treatment ideally should have begun. The desired outcome of treatment is a long-term plasma HIV-RNA count below 50 copies/mL. Levels to determine if treatment is effective are initially recommended after four weeks and once levels fall below 50 copies/mL checks every three to six months are typically adequate. Inadequate control is deemed to be greater than 400 copies/mL. Based on these criteria treatment is effective in more than 95% of people during the first year. Benefits of treatment include a decreased risk of progression to AIDS and a decreased risk of death. In the developing world, treatment also improves physical and mental health. With treatment, there is a 70% reduced risk of acquiring tuberculosis. Additional benefits include a decreased risk of transmission of the disease to sexual partners and a decrease in mother-to-child transmission. The effectiveness of treatment depends to a large part on compliance. Reasons for non-adherence to treatment include poor access to medical care, inadequate social supports, [[mental illness and [[drug abuse. The complexity of treatment regimens (due to pill numbers and dosing frequency) and [[adverse effects may reduce adherence. Even though cost is an important issue with some medications, 47% of those who needed them were taking them in low- and middle-income countries , and the rate of adherence is similar in low-income and high-income countries. Specific adverse events are related to the antiretroviral agent taken. Some relatively common adverse events include: [[HIV-associated lipodystrophy|lipodystrophy syndrome, [[dyslipidemia, and [[diabetes mellitus, especially with protease inhibitors. Other common symptoms include diarrhea, and an increased risk of [[cardiovascular disease. Newer recommended treatments are associated with fewer adverse effects. Certain medications may be associated with [[birth defects and therefore may be unsuitable for women hoping to have children. Treatment recommendations for children are somewhat different from those for adults. The World Health Organization recommends treating all children less than five years of age; children above five are treated like adults. The United States guidelines recommend treating all children less than 12 months of age and all those with HIV RNA counts greater than 100,000 copies/mL between one year and five years of age. The [[European Medicines Agency (EMA) has recommended the granting of marketing authorizations for two new antiretroviral (ARV) medicines, [[rilpivirine (Rekambys) and [[cabotegravir (Vocabria), to be used together for the treatment of people with human immunodeficiency virus type 1 (HIV-1) infection. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged. The two medicines are the first ARVs that come in a long-acting injectable formulation. This means that instead of daily pills, people receive intramuscular injections monthly or every two months. The combination of Rekambys and Vocabria injection is intended for maintenance treatment of adults who have undetectable HIV levels in the blood (viral load less than 50 copies/ml) with their current ARV treatment, and when the virus has not developed resistance to certain class of anti-HIV medicines called non-nucleoside reverse transcriptase inhibitors (NNRTIs) and integrase strand transfer inhibitors (INIs). [[Cabotegravir/rilpivirine|Cabotegravir combined with rilpivirine (Cabenuva) is a complete regimen for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults to replace a current antiretroviral regimen in those who are virologically suppressed on a stable antiretroviral regimen with no history of treatment failure and with no known or suspected resistance to either [[cabotegravir or [[rilpivirine.


Opportunistic infections

Measures to prevent opportunistic infections are effective in many people with HIV/AIDS. In addition to improving current disease, treatment with antiretrovirals reduces the risk of developing additional opportunistic infections. Adults and adolescents who are living with HIV (even on anti-retroviral therapy) with no evidence of active tuberculosis in settings with high tuberculosis burden should receive [[Isoniazid|isoniazid preventive therapy (IPT); the [[Mantoux test|tuberculin skin test can be used to help decide if IPT is needed. [[Vaccination against [[hepatitis A and B is advised for all people at risk of HIV before they become infected; however, it may also be given after infection. [[Trimethoprim/sulfamethoxazole prophylaxis between four and six weeks of age, and ceasing breastfeeding of infants born to HIV-positive mothers, is recommended in resource-limited settings.UNAIDS 2011 pg. 150–160 It is also recommended to prevent PCP when a person's CD4 count is below 200 cells/uL and in those who have or have previously had PCP. People with substantial immunosuppression are also advised to receive prophylactic therapy for [[toxoplasmosis and [[Mycobacterium avium-intracellulare infection|MAC. Appropriate preventive measures reduced the rate of these infections by 50% between 1992 and 1997. [[Influenza vaccination and [[pneumococcal polysaccharide vaccine are often recommended in people with HIV/AIDS with some evidence of benefit.


Diet

The World Health Organization (WHO) has issued recommendations regarding nutrient requirements in HIV/AIDS. A generally healthy diet is promoted. Dietary intake of micronutrients at [[Reference Daily Intake|RDA levels by HIV-infected adults is recommended by the WHO; higher intake of [[vitamin A, [[zinc, and iron can produce adverse effects in HIV-positive adults, and is not recommended unless there is documented deficiency. Dietary supplementation for people who are infected with HIV and who have inadequate nutrition or dietary deficiencies may strengthen their immune systems or help them recover from infections; however, evidence indicating an overall benefit in morbidity or reduction in mortality is not consistent. Evidence for supplementation with [[selenium is mixed with some tentative evidence of benefit. For pregnant and lactating women with HIV, [[multivitamin supplement improves outcomes for both mothers and children. If the pregnant or lactating mother has been advised to take anti-retroviral medication to prevent mother-to-child HIV transmission, multivitamin supplements should not replace these treatments. There is some evidence that vitamin A supplementation in children with an HIV infection reduces mortality and improves growth.


Alternative medicine

In the US, approximately 60% of people with HIV use various forms of [[alternative medicine|complementary or alternative medicine, whose effectiveness has not been established. There is not enough evidence to support the use of [[herbal medicines. There is insufficient evidence to recommend or support the use of [[medical cannabis to try to increase appetite or weight gain.


Prognosis

HIV/AIDS has become a [[Chronic (medicine)|chronic rather than an acutely fatal disease in many areas of the world. Prognosis varies between people, and both the CD4 count and viral load are useful for predicted outcomes. Without treatment, average survival time after infection with HIV is estimated to be 9 to 11 years, depending on the HIV subtype. After the diagnosis of AIDS, if treatment is not available, survival ranges between 6 and 19 months. [[HAART and appropriate prevention of opportunistic infections reduces the death rate by 80%, and raises the life expectancy for a newly diagnosed young adult to 20–50 years. This is between two thirds and nearly that of the general population. If treatment is started late in the infection, prognosis is not as good: for example, if treatment is begun following the diagnosis of AIDS, life expectancy is ~10–40 years. Half of infants born with HIV die before two years of age without treatment. The primary causes of death from HIV/AIDS are
opportunistic infections An opportunistic infection is an infection caused by pathogens (bacteria, fungi, parasites or viruses) that take advantage of an opportunity not normally available. These opportunities can stem from a variety of sources, such as a weakened immune s ...

opportunistic infections
and [[cancer, both of which are frequently the result of the progressive failure of the immune system. Risk of cancer appears to increase once the CD4 count is below 500/μL. The rate of clinical disease progression varies widely between individuals and has been shown to be affected by a number of factors such as a person's susceptibility and immune function; their access to health care, the presence of co-infections; and the particular strain (or strains) of the virus involved. [[Tuberculosis co-infection is one of the leading causes of sickness and death in those with HIV/AIDS being present in a third of all HIV-infected people and causing 25% of HIV-related deaths. HIV is also one of the most important risk factors for tuberculosis. [[Hepatitis C is another very common co-infection where each disease increases the progression of the other. The two most common cancers associated with HIV/AIDS are
Kaposi's sarcoma Kaposi's sarcoma (KS) is a type of cancer that can form masses in the skin, lymph nodes, or other organs. The skin lesions are usually purple in color. They can occur singly or in a limited area, or may be widespread. It may worsen either graduall ...

Kaposi's sarcoma
and AIDS-related [[non-Hodgkin's lymphoma. Other cancers that are more frequent include [[anal cancer,
Burkitt's lymphoma Burkitt lymphoma is a cancer of the lymphatic system, particularly B lymphocytes found in the germinal center. It is named after Denis Parsons Burkitt, the Irish surgeon who first described the disease in 1958 while working in equatorial Africa. Th ...

Burkitt's lymphoma
, , and
cervical cancer Cervical cancer is a cancer arising from the cervix. It is due to the abnormal growth of cells that have the ability to invade or spread to other parts of the body. Early on, typically no symptoms are seen. Later symptoms may include abnormal vagi ...

cervical cancer
. Even with anti-retroviral treatment, over the long term HIV-infected people may experience [[AIDS dementia complex|neurocognitive disorders, [[osteoporosis, [[peripheral neuropathy|neuropathy, cancers, [[nephropathy, and [[cardiovascular disease. Some conditions, such as [[lipodystrophy, may be caused both by HIV and its treatment.


Epidemiology

HIV/AIDS is a global [[pandemic. approximately 36.7 million people worldwide have HIV, the number of new infections that year being about 1.8 million. This is down from 3.1 million new infections in 2001. Slightly over half the infected population are women and 2.1 million are children. It resulted in about 1 million deaths in 2016, down from a peak of 1.9 million in 2005. [[AIDS epidemiology#Sub-Saharan Africa|Sub-Saharan Africa is the region most affected. In 2010, an estimated 68% (22.9 million) of all HIV cases and 66% of all deaths (1.2 million) occurred in this region.UNAIDS 2011 pg. 20–30 This means that about 5% of the adult population is infectedUNAIDS 2011 pp. 40–50 and it is believed to be the cause of 10% of all deaths in children.Mandell, Bennett, and Dolan (2010). Chapter 117. Here, in contrast to other regions, women comprise nearly 60% of cases. [[South Africa has the largest population of people with HIV of any country in the world at 5.9 million. [[Life expectancy has fallen in the worst-affected countries due to HIV/AIDS; for example, in 2006 it was estimated that it had dropped from 65 to 35 years in [[Botswana. Mother-to-child transmission in Botswana and South Africa, , has decreased to less than 5%, with improvement in many other African nations due to improved access to antiretroviral therapy. [[AIDS epidemiology#South and South-East Asia|South & South East Asia is the second most affected; in 2010 this region contained an estimated 4 million cases or 12% of all people living with HIV resulting in approximately 250,000 deaths. Approximately 2.4 million of these cases are in India. During 2008 in the United States approximately 1.2 million people were living with HIV, resulting in about 17,500 deaths. The US Centers for Disease Control and Prevention estimated that in that year, 20% of infected Americans were unaware of their infection. about 675,000 people have died of HIV/AIDS in the US since the beginning of the HIV epidemic. In the [[HIV/AIDS in the United Kingdom|United Kingdom , there were approximately 101,200 cases which resulted in 594 deaths. In Canada as of 2008, there were about 65,000 cases causing 53 deaths. Between the first recognition of AIDS (in 1981) and 2009, it has led to nearly 30 million deaths. Rates of HIV are lowest in North Africa and the Middle East (0.1% or less), [[East Asia (0.1%), and Western and Central Europe (0.2%). The worst-affected European countries, in 2009 and 2012 estimates, are [[Russia, [[Ukraine, [[Latvia, [[Moldova, [[Portugal and [[Belarus, in decreasing order of prevalence.


History


Discovery

The first news story on the disease appeared May 18, 1981 in the gay newspaper ''[[New York Native''. AIDS was first clinically reported on June 5, 1981, with five cases in the United States. The initial cases were a cluster of injecting drug users and gay men with no known cause of impaired immunity who showed symptoms of ''[[Pneumocystis carinii'' pneumonia (PCP), a rare opportunistic infection that was known to occur in people with very compromised immune systems. Soon thereafter, an unexpected number of homosexual men developed a previously rare skin cancer called
Kaposi's sarcoma Kaposi's sarcoma (KS) is a type of cancer that can form masses in the skin, lymph nodes, or other organs. The skin lesions are usually purple in color. They can occur singly or in a limited area, or may be widespread. It may worsen either graduall ...

Kaposi's sarcoma
(KS). Many more cases of PCP and KS emerged, alerting U.S. Centers for Disease Control and Prevention (CDC) and a CDC task force was formed to monitor the outbreak. In the early days, the CDC did not have an official name for the disease, often referring to it by way of diseases associated with it, such as [[lymphadenopathy, the disease after which the discoverers of HIV originally named the virus. They also used ''Kaposi's sarcoma and opportunistic infections'', the name by which a task force had been set up in 1981. At one point the CDC referred to it as the "4H disease", as the syndrome seemed to affect heroin users, homosexuals, [[haemophilia|hemophiliacs, and [[Haitians. The term ''GRID'', which stood for [[gay-related immune deficiency, had also been coined. However, after determining that AIDS was not isolated to the [[gay community, it was realized that the term ''GRID'' was misleading, and the term ''AIDS'' was introduced at a meeting in July 1982. By September 1982 the CDC started referring to the disease as AIDS. In 1983, two separate research groups led by [[Robert Gallo and [[Luc Montagnier declared that a novel retrovirus may have been infecting people with AIDS, and published their findings in the same issue of the journal ''[[Science (journal)|Science''. Gallo claimed a virus which his group had isolated from a person with AIDS was strikingly similar in [[Virus structure|shape to other [[human T-lymphotropic viruses (HTLVs) that his group had been the first to isolate. Gallo's group called their newly isolated virus HTLV-III. At the same time, Montagnier's group isolated a virus from a person presenting with swelling of the [[lymph nodes of the neck and [[Asthenia|physical weakness, two characteristic symptoms of AIDS. Contradicting the report from Gallo's group, Montagnier and his colleagues showed that core proteins of this virus were immunologically different from those of HTLV-I. Montagnier's group named their isolated virus lymphadenopathy-associated virus (LAV). As these two viruses turned out to be the same, in 1986, LAV and HTLV-III were renamed HIV.


Origins

Both HIV-1 and HIV-2 are believed to have originated in non-human [[primates in West-central Africa and were [[zoonosis|transferred to humans in the early 20th century. HIV-1 appears to have originated in southern [[Cameroon through the evolution of SIV(cpz), a [[simian immunodeficiency virus (SIV) that infects wild [[Common chimpanzee|chimpanzees (HIV-1 descends from the SIVcpz endemic in the chimpanzee subspecies ''Pan troglodytes troglodytes''). The closest relative of HIV-2 is SIV (smm), a virus of the [[sooty mangabey (''Cercocebus atys atys''), an [[Old World monkey living in coastal West Africa (from southern [[Senegal to western [[Ivory Coast). [[New World monkeys such as the [[Night monkey|owl monkey are resistant to [[Subtypes of HIV|HIV-1 infection, possibly because of a genomic [[fusion gene|fusion of two viral resistance genes.(subscription required) HIV-1 is thought to have jumped the species barrier on at least three separate occasions, giving rise to the three groups of the virus, M, N, and O. There is evidence that humans who participate in [[bushmeat activities, either as hunters or as bushmeat vendors, commonly acquire SIV. However, SIV is a weak virus which is typically suppressed by the human immune system within weeks of infection. It is thought that several transmissions of the virus from individual to individual in quick succession are necessary to allow it enough time to mutate into HIV. Furthermore, due to its relatively low person-to-person transmission rate, SIV can only spread throughout the population in the presence of one or more high-risk transmission channels, which are thought to have been absent in Africa before the 20th century. Specific proposed high-risk transmission channels, allowing the virus to adapt to humans and spread throughout the society, depend on the proposed timing of the animal-to-human crossing. Genetic studies of the virus suggest that the most recent common ancestor of the HIV-1 M group dates back to 1910. (subscription required) Proponents of this dating link the HIV epidemic with the emergence of [[colonialism and growth of large colonial African cities, leading to social changes, including a higher degree of sexual promiscuity, the spread of prostitution, and the accompanying high frequency of [[genital ulcer diseases (such as [[syphilis) in nascent colonial cities. While transmission rates of HIV during vaginal intercourse are low under regular circumstances, they are increased manyfold if one of the partners suffers from a [[Sexually transmitted disease|sexually transmitted infection causing genital ulcers. Early 1900s colonial cities were notable for their high prevalence of prostitution and genital ulcers, to the degree that, as of 1928, as many as 45% of female residents of eastern [[Kinshasa were thought to have been prostitutes, and, as of 1933, around 15% of all residents of the same city had syphilis. An alternative view holds that unsafe medical practices in Africa after World War II, such as unsterile reuse of single-use syringes during mass vaccination, antibiotic and anti-malaria treatment campaigns, were the initial vector that allowed the virus to adapt to humans and spread.(subscription required) The earliest well-documented case of HIV in a human dates back to 1959 in the [[Belgian Congo|Congo. The earliest retrospectively described case of AIDS is believed to have been in Norway beginning in 1966. In July 1960, in the wake of [[Democratic Republic of the Congo#Independence and political crisis (1960–65)|Congo's independence, the [[United Nations recruited [[French language|Francophone experts and technicians from all over the world to assist in filling administrative gaps left by [[Belgium, who did not leave behind an African elite to run the country. By 1962, Haitians made up the second-largest group of well-educated experts (out of the 48 national groups recruited), that totaled around 4500 in the country. Dr. Jacques Pépin, a [[Quebecer author of ''The Origins of AIDS'', stipulates that Haiti was one of HIV's entry points to the United States and that one of them may have carried HIV back across the Atlantic in the 1960s. Although the virus may have been present in the United States as early as 1966, the vast majority of infections occurring outside sub-Saharan Africa (including the U.S.) can be traced back to a single unknown individual who became infected with HIV in [[Haiti and then brought the infection to the United States at some time around 1969. The epidemic then rapidly spread among high-risk groups (initially, sexually promiscuous men who have sex with men). By 1978, the prevalence of HIV-1 among gay male residents of [[New York City and [[San Francisco was estimated at 5%, suggesting that several thousand individuals in the country had been infected.


Society and culture


Stigma

AIDS stigma exists around the world in a variety of ways, including [[shunning|ostracism, [[Social rejection|rejection, discrimination and avoidance of HIV-infected people; compulsory HIV testing without prior [[consent or protection of [[confidentiality; violence against HIV-infected individuals or people who are perceived to be infected with HIV; and the [[quarantine of HIV-infected individuals. Stigma-related violence or the fear of violence prevents many people from seeking HIV testing, returning for their results, or securing treatment, possibly turning what could be a manageable chronic illness into a death sentence and perpetuating the spread of HIV. AIDS stigma has been further divided into the following three categories: * ''Instrumental AIDS stigma''—a reflection of the fear and apprehension that are likely to be associated with any deadly and transmissible illness. * ''Symbolic AIDS stigma''—the use of HIV/AIDS to express attitudes toward the social groups or lifestyles perceived to be associated with the disease. * ''Courtesy AIDS stigma''—stigmatization of people connected to the issue of HIV/AIDS or HIV-positive people. Often, AIDS stigma is expressed in conjunction with one or more other stigmas, particularly those associated with homosexuality, [[bisexuality, [[promiscuity, prostitution, and [[Intravenous drug use (recreational)|intravenous drug use. In many [[Developed country|developed countries, there is [[AIDS and homosexuality|an association between AIDS and homosexuality or bisexuality, and this association is correlated with higher levels of sexual prejudice, such as [[Homophobia|anti-homosexual or [[Biphobia|anti-bisexual attitudes. There is also a perceived association between AIDS and all male-male sexual behavior, including sex between uninfected men. However, the dominant mode of spread worldwide for HIV remains heterosexual transmission. In 2003, as part of an overall reform of marriage and population legislation, it became legal for people with AIDS to marry in China. In 2013, the [[National Library of Medicine|U.S. National Library of Medicine developed a traveling exhibition titled ''Surviving and Thriving: AIDS, Politics, and Culture''; this covered medical research, the U.S. government's response, and personal stories from people with AIDS, caregivers, and activists.


Economic impact

HIV/AIDS affects the economics of both individuals and countries. The [[gross domestic product of the most affected countries has decreased due to the lack of [[human capital. Without proper nutrition, health care and medicine, large numbers of people die from AIDS-related complications. Before death they will not only be unable to work, but will also require significant medical care. It is estimated that as of 2007 there were 12 million [[AIDS orphans. Many are cared for by elderly grandparents. Returning to work after beginning treatment for HIV/AIDS is difficult, and affected people often work less than the average worker. [[Unemployment in people with HIV/AIDS also is associated with [[suicidal ideation, memory problems, and social isolation. Employment increases [[self-esteem, sense of dignity, confidence, and [[quality of life for people with HIV/AIDS. Anti-retroviral treatment may help people with HIV/AIDS work more, and may increase the chance that a person with HIV/AIDS will be employed (low-quality evidence). By affecting mainly young adults, AIDS reduces the taxable population, in turn reducing the resources available for [[government spending|public expenditures such as education and health services not related to AIDS, resulting in increasing pressure on the state's finances and slower growth of the economy. This causes a slower growth of the tax base, an effect that is reinforced if there are growing expenditures on treating the sick, training (to replace sick workers), sick pay and caring for AIDS orphans. This is especially true if the sharp increase in adult mortality shifts the responsibility from the family to the government in caring for these orphans. At the household level, AIDS causes both loss of income and increased spending on healthcare. A study in [[Côte d'Ivoire showed that households having a person with HIV/AIDS spent twice as much on medical expenses as other households. This additional expenditure also leaves less income to spend on education and other personal or family investment.


Religion and AIDS

The topic of religion and AIDS has become highly controversial, primarily because some religious authorities have publicly declared their opposition to the use of condoms. The religious approach to prevent the spread of AIDS, according to a report by American health expert Matthew Hanley titled ''The Catholic Church and the Global AIDS Crisis'', argues that cultural changes are needed, including a re-emphasis on fidelity within marriage and sexual abstinence outside of it. Some religious organizations have claimed that prayer can cure HIV/AIDS. In 2011, the BBC reported that some churches in London were claiming that prayer would cure AIDS, and the [[London Borough of Hackney|Hackney-based Centre for the Study of Sexual Health and HIV reported that several people stopped taking their medication, sometimes on the direct advice of their pastor, leading to a number of deaths. The [[Synagogue Church Of All Nations advertised an "anointing water" to promote God's healing, although the group denies advising people to stop taking medication.


Media portrayal

One of the first high-profile cases of AIDS was the American [[Rock Hudson, a gay actor who had been married and divorced earlier in life, who died on October 2, 1985, having announced that he was suffering from the virus on July 25 that year. He had been diagnosed during 1984. A notable British casualty of AIDS that year was [[Nicholas Eden, 2nd Earl of Avon|Nicholas Eden, a gay politician and son of the late prime minister [[Anthony Eden. On November 24, 1991, the virus claimed the life of British rock star [[Freddie Mercury, lead singer of the band [[Queen (band)|Queen, who died from an AIDS-related illness having only revealed the diagnosis on the previous day. However, he had been diagnosed as HIV-positive in 1987. Mercury had also begun to show signs of the virus as early as 1982. One of the first high-profile heterosexual cases of the virus was American tennis player [[Arthur Ashe. He was diagnosed as HIV-positive on August 31, 1988, having contracted the virus from blood transfusions during heart surgery earlier in the 1980s. Further tests within 24 hours of the initial diagnosis revealed that Ashe had AIDS, but he did not tell the public about his diagnosis until April 1992. He died as a result on February 6, 1993, aged 49. Therese Frare's photograph of gay activist [[David Kirby (activist)|David Kirby, as he lay dying from AIDS while surrounded by family, was taken in April 1990. ''[[Life (magazine)|Life'' magazine said the photo became the one image "most powerfully identified with the HIV/AIDS epidemic." The photo was displayed in ''Life'', was the winner of the [[World Press Photo, and acquired worldwide notoriety after being used in a [[United Colors of Benetton advertising campaign in 1992.


Criminal transmission

Criminal transmission of HIV is the [[intention (criminal law)|intentional or [[recklessness (law)|reckless infection of a person with the
human immunodeficiency virus The human immunodeficiency viruses (HIV) are two species of ''Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune ...

human immunodeficiency virus
(HIV). Some countries or jurisdictions, including some areas of the United States, have laws that criminalize HIV transmission or exposure. Others may charge the accused under laws enacted before the HIV pandemic. In 1996, Ugandan-born Canadian [[Johnson Aziga was diagnosed with HIV; he subsequently had unprotected sex with eleven women without disclosing his diagnosis. By 2003, seven had contracted HIV; two died from complications related to AIDS. Aziga was convicted of [[first-degree murder and sentenced to [[Life imprisonment in Canada|life imprisonment.


Misconceptions

There are many [[misconceptions about HIV and AIDS. Three of the most common are that AIDS can spread through casual contact, that [[Virgin cleansing myth|sexual intercourse with a virgin will cure AIDS, and that HIV can infect only gay men and drug users. In 2014, some among the British public wrongly thought one could get HIV from kissing (16%), sharing a glass (5%), spitting (16%), a public toilet seat (4%), and coughing or sneezing (5%). Other misconceptions are that any act of anal intercourse between two uninfected gay men can lead to HIV infection, and that open discussion of HIV and homosexuality in schools will lead to increased rates of AIDS. A small group of individuals continue to dispute the connection between HIV and AIDS, the existence of HIV itself, or the validity of HIV testing and treatment methods. These claims, known as [[AIDS denialism, have been examined and rejected by the scientific community. However, they have had a significant political impact, particularly [[HIV/AIDS denialism in South Africa|in South Africa, where the government's official embrace of AIDS denialism (1999–2005) was responsible for its ineffective response to that country's AIDS epidemic, and has been blamed for hundreds of thousands of avoidable deaths and HIV infections. Several discredited [[conspiracy theories have held that HIV was created by scientists, either inadvertently or deliberately. [[Operation INFEKTION was a worldwide Soviet [[active measures operation to spread the claim that the United States had created HIV/AIDS. Surveys show that a significant number of people believed—and continue to believe—in such claims.


Research

HIV/AIDS research includes all [[medical research which attempts to prevent, treat, or cure HIV/AIDS, along with fundamental research about the nature of HIV as an infectious agent, and about AIDS as the disease caused by HIV. Many governments and research institutions participate in HIV/AIDS research. This research includes behavioral [[health interventions such as [[sex education, and [[drug development, such as research into [[microbicides for sexually transmitted diseases, [[HIV vaccines, and [[antiretroviral drugs. Other medical research areas include the topics of [[pre-exposure prophylaxis,
post-exposure prophylaxis Post-exposure prophylaxis, also known as post-exposure prevention (PEP), is any preventive medical treatment started after exposure to a pathogen in order to prevent the infection from occurring. Rabies PEP is commonly and very effectively used t ...

post-exposure prophylaxis
, and [[circumcision and HIV. Public health officials, researchers, and programs can gain a more comprehensive picture of the barriers they face, and the efficacy of current approaches to HIV treatment and prevention, by tracking standard HIV indicators. Use of common indicators is an increasing focus of development organizations and researchers.


References


External links

*
UNAIDS
– Joint United Nations Program on HIV/AIDS.
AIDSinfo
– Information on HIV/AIDS treatment, prevention, and research, U.S. Department of Health and Human Services.
2018 Recommendations of the International Antiviral Society
{{DEFAULTSORT:HIV AIDS [[Category:HIV/AIDS| [[Category:1981 in biology [[Category:Articles containing video clips [[Category:Health disasters [[Category:Pandemics [[Category:Slow virus diseases [[Category:Syndromes|Aids [[Category:Wikipedia medicine articles ready to translate (full) [[Category:RTTID