The Atherosclerosis Risk in Communities (ARIC) Study is a multi-site, prospective, biracial

cohort study A cohort study is a particular form of longitudinal study that samples a cohort (a group of people who share a defining characteristic, typically those who experienced a common event in a selected period, such as birth or graduation), performing ...

funded by the

National Heart, Lung, and Blood Institute The National Heart, Lung, and Blood Institute (NHLBI) is the third largest Institute of the National Institutes of Health, located in Bethesda, Maryland, United States. It is tasked with allocating about $3.6 billion in FY 2020 in tax revenue to ...

of the

National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...

. The ARIC Study was designed to investigate the etiology and clinical outcomes of

atherosclerosis Atherosclerosis is a pattern of the disease arteriosclerosis in which the wall of the artery develops abnormalities, called lesions. These lesions may lead to narrowing due to the buildup of atheroma, atheromatous plaque. At onset there are usu ...

. A total of 15,792 middle-aged (45–64 years) men and women were enrolled from four U.S. communities: *

Forsyth County, North Carolina Forsyth County is located in the northwest Piedmont of the U.S. state of North Carolina. As of the 2020 census, the population was 382,590, making it the fourth-most populous county in North Carolina. Its county seat is Winston-Salem. Forsyth ...

Jackson, Mississippi Jackson, officially the City of Jackson, is the Capital city, capital of and the List of municipalities in Mississippi, most populous city in the U.S. state of Mississippi. The city is also one of two county seats of Hinds County, Mississippi, ...

* Suburbs of

Minneapolis, Minnesota Minneapolis () is the largest city in Minnesota, United States, and the county seat of Hennepin County. The city is abundant in water, with thirteen lakes, wetlands, the Mississippi River, creeks and waterfalls. Minneapolis has its origins ...

Washington County, Maryland Washington County is located in the western part of the U.S. state of Maryland. As of the 2020 census, the population was 154,705. Its county seat is Hagerstown. Washington County was the first county in the United States to be named for the ...

Participating organizations include four field centers (

Wake Forest Baptist Medical Center Atrium Health Wake Forest Baptist is an academic medical center and health system located in Winston-Salem, North Carolina, and part of Charlotte-based Atrium Health. It is the largest employer in Forsyth County, with more than 19,220 employee ...

University of Mississippi Medical Center University of Mississippi Medical Center (UMMC) is the health sciences campus of the University of Mississippi (Ole Miss) and is located in Jackson, Mississippi, United States. UMMC, also referred to as the Medical Center, is the state's only aca ...

University of Minnesota The University of Minnesota, formally the University of Minnesota, Twin Cities, (UMN Twin Cities, the U of M, or Minnesota) is a public university, public Land-grant university, land-grant research university in the Minneapolis–Saint Paul, Tw ...

Johns Hopkins University Johns Hopkins University (Johns Hopkins, Hopkins, or JHU) is a private university, private research university in Baltimore, Maryland. Founded in 1876, Johns Hopkins is the oldest research university in the United States and in the western hem ...

), data coordinating center (

University of North Carolina at Chapel Hill A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. Universities typically offer both undergraduate and postgraduate programs. In the United States ...

), and many collaborating centers and laboratories. The initial study visit took place in 1987-1989, the second in 1990-1992, the third in 1993-1995, the fourth in 1996-1998, and the fifth in 2011-2013. During these extensive examinations, information is obtained on demographics, medical history, medication use, and health behaviors. To date, the ARIC study has published over 1,000 peer-reviewed journal articles in diverse areas of clinical and population research. Data from the ARIC study have become an important resource for the study of heart disease,

kidney disease Kidney disease, or renal disease, technically referred to as nephropathy, is damage to or disease of a kidney. Nephritis is an inflammatory kidney disease and has several types according to the location of the inflammation. Inflammation can ...

diabetes Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ap ...

, and

cognitive Cognition refers to "the mental action or process of acquiring knowledge and understanding through thought, experience, and the senses". It encompasses all aspects of intellectual functions and processes such as: perception, attention, thought, ...

decline. These data have also contributed to clinical practice guidelines and policy statements. ARIC is registered at ClinicalTrials.gov registry under trial identifier NCT00005131.

References

{{Reflist Epidemiological study projects Cohort studies Epidemiology