Aspergillopepsin I (, ''Aspergillus acid protease'', ''Aspergillus acid proteinase'', ''Aspergillus aspartic proteinase'', ''Aspergillus awamori acid proteinase'', ''Aspergillus carboxyl proteinase'', ''carboxyl proteinase'', ''Aspergillus kawachii aspartic proteinase'', ''Aspergillus saitoi acid proteinase'', ''pepsin-type aspartic proteinase'', ''Aspergillus niger acid proteinase'', ''sumizyme AP'', ''proctase P'', ''denapsin'', ''denapsin XP 271'', ''proctase'') is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
.
This enzyme
catalyses the following
chemical reaction
A chemical reaction is a process that leads to the IUPAC nomenclature for organic transformations, chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the pos ...
:
Hydrolysis
Hydrolysis (; ) is any chemical reaction in which a molecule of water breaks one or more chemical bonds. The term is used broadly for substitution reaction, substitution, elimination reaction, elimination, and solvation reactions in which water ...
of proteins with broad specificity. Generally favours
hydrophobic
In chemistry, hydrophobicity is the physical property of a molecule that is seemingly repelled from a mass of water (known as a hydrophobe). In contrast, hydrophiles are attracted to water.
Hydrophobic molecules tend to be nonpolar and, th ...
residues in P1 and P1', but also accepts Lys in P1, which leads to activation of
trypsinogen Trypsinogen () is the precursor form (or zymogen) of trypsin, a digestive enzyme. It is produced by the pancreas and found in pancreatic juice, along with amylase, lipase, and chymotrypsinogen. It is cleaved to its active form, trypsin, by enterop ...
. Does not clot milk
This enzyme is found in a variety of ''
Aspergillus
' () is a genus consisting of several hundred mold species found in various climates worldwide.
''Aspergillus'' was first catalogued in 1729 by the Italian priest and biologist Pier Antonio Micheli. Viewing the fungi under a microscope, Miche ...
'' species.
See also
*
Trypsinogen Trypsinogen () is the precursor form (or zymogen) of trypsin, a digestive enzyme. It is produced by the pancreas and found in pancreatic juice, along with amylase, lipase, and chymotrypsinogen. It is cleaved to its active form, trypsin, by enterop ...
References
External links
*
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EC 3.4.23