If terminal
sialic acid residues are removed from
glycoproteins, the resulting proteins are known as asialoglycoproteins.
The exposure of the subterminal
galactose
Galactose (, '' galacto-'' + ''-ose'', "milk sugar"), sometimes abbreviated Gal, is a monosaccharide sugar that is about as sweet as glucose, and about 65% as sweet as sucrose. It is an aldohexose and a C-4 epimer of glucose. A galactose molecu ...
residues results in rapid clearance of the glycoproteins from the circulation through
hepatocyte
A hepatocyte is a cell of the main parenchymal tissue of the liver. Hepatocytes make up 80% of the liver's mass.
These cells are involved in:
* Protein synthesis
* Protein storage
* Transformation of carbohydrates
* Synthesis of cholesterol, ...
asialoglycoprotein receptors on
Kuppfer cells.
External links
*
References
Transmembrane proteins
{{Glycoproteins