Asen A. Hadjiolov ( bg, Асен А. Хаджиолов) (December 10, 1930 - April 22, 1996) was one of the most distinguished scientists in Bulgaria, and was a member of the

Bulgarian Academy of Sciences The Bulgarian Academy of Sciences (abbreviated BAS; bg, Българска академия на науките, ''Balgarska akademiya na naukite'', abbreviated ''БАН'') is the National Academy of Bulgaria, established in 1869. The Academy ...

Vita in brief

Hadjiolov's scholarly research on the nucleolus and

ribosome Ribosomes ( ) are macromolecular machines, found within all cells, that perform biological protein synthesis (mRNA translation). Ribosomes link amino acids together in the order specified by the codons of messenger RNA (mRNA) molecules to ...

biogenesis and his leadership in the scientific community touched many lives. As a young researcher he followed the path of his father: Professor Asen I. Hadjiolov was a well-known

Bulgarian Bulgarian may refer to: * Something of, from, or related to the country of Bulgaria * Bulgarians, a South Slavic ethnic group * Bulgarian language, a Slavic language * Bulgarian alphabet * A citizen of Bulgaria, see Demographics of Bulgaria * Bul ...

histologist and cytologist. Hadjiolov began experimental work in the Department of Biochemistry of the Medical Faculty of Sofia and was awarded the PhD in 1958 for his studies on the role of nucleic acids in cancer. In 1963 Hadjiolov became chair of the Department of Molecular Genetics in the Central Laboratory of Biochemistry, which was transformed into the Institute of Molecular Biology of the

in 1969. During his early years, Hadjiolov had the chance to work with such eminent scientists as F.B. Straub ( Budapest), R Grabar (Paris), the Nobel Prize winner Fritz Lipmann ( Cold Spring Harbor, New York) and later with R. Cox (London) and D. Sabatini (New York). Early on, he became fascinated by the structure and biosynthesis of ribosomal RNA (rRNA) and the biogenesis of eukaryotic

ribosomes Ribosomes ( ) are macromolecular machines, found within all cells, that perform biological protein synthesis (mRNA translation). Ribosomes link amino acids together in the order specified by the codons of messenger RNA (mRNA) molecules to f ...

Mechanisms of regulation of rRNA synthesis

Hadjiolov's laboratory was the first to provide reliable evidence that the change in the rate of rRNA synthesis in higher

eukaryotes Eukaryotes () are organisms whose cells have a nucleus. All animals, plants, fungi, and many unicellular organisms, are Eukaryotes. They belong to the group of organisms Eukaryota or Eukarya, which is one of the three domains of life. Bacte ...

is not accompanied by alterations in the number of active

genes In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...

. During his active research years Hadjiolov published more than hundred of articles focused on the

(see PubMed for a complete list). Hadjiolov's list of publications totals 106 listed in PubMed. Hadjiolov's contribution to the world's science can also be measured by contribution of the scientists he recruited and supported throughout his career. All together the heritage of his group exceeds 1,000 articles annotated by PubMed, which matches today's highest quantitative achievements in science. For example, the most cited author since 1994 by the Institute for Scientific Information's Citation Report, Dr. John C. Reed ( Burnham Institute for Medical Research) and his group have reached similar number of articles ( PubMed:728 as of April 4, 2007).Science Watch 2000

Science Heritage

Hadjiolov's group (not limited to this list, cumulative PubMed count > 860 articles): :♦ Krasimira V. Hadjiolova, PhD (23) NYU Langone Medical Center (New York) :♦ Nikolai Nikolaev, PhD (111) (1943 - 2004) :♦ Kalin P. Dudov, PhD, (15) Inst. of Genetic Engineering, Bulgaria :♦ Pencho Venkov, PhD (64) Sofia University :♦ Mariana D. Dabeva, PhD, (57) Albert Einstein College of Medicine :♦ Violetta Iotsova, PhD, (11
Bristol-Myers Squibb Pharmaceutical Research Institute
:♦ Raina N. Ikonomova PhD, (4) not active in research :♦ Svetlana I. Gramatikova, PhD, (9) Burnham Institute for Medical Research :♦ Georgi Milchev, PhD, (13) Inst. of Mol. Biol.,

:♦ Ivan I. Todorov, (221) PhD, City of Hope National Medical Center :♦ Milko M. Kermekchiev, PhD (12) Washington University in St. Louis :♦ Radka Philipova, PhD, (14)

Newcastle University Newcastle University (legally the University of Newcastle upon Tyne) is a UK public university, public research university based in Newcastle upon Tyne, North East England. It has overseas campuses in Singapore and Malaysia. The university is ...

:♦ Nikolai Zhelev, PhD, (28) University of Abertay Dundee :♦ Krasimir Y. Yankulov, PhD (19) University of Toronto :♦ Alex P. Vassilev, PhD, (105) University of Aarhus :♦ Luchezar K. Karagyozov, PhD, (15) Friedrich Schiller University of Jena :♦ Iveta D. Kalcheva, PhD (14
UCSD Cancer Center

UCSD Medical Center The University of California, San Diego (UC San Diego or colloquially, UCSD) is a public land-grant research university in San Diego, California. Established in 1960 near the pre-existing Scripps Institution of Oceanography, UC San Diego is t ...

:♦ Irina Stancheva, PhD, (22) University of Edinburgh :♦ Oleg I. Georgiev, PhD, (99
Institut für Molekularbiologie
Universität Zürich :♦ Peter Milev, MD, PhD, (17) University of Iowa :♦ Kosi Gramatikoff, PhD, (9) Burnham Institute for Medical Research

References

External links

br>official website
* {{DEFAULTSORT:Hadjiolov, Asen Bulgarian biologists 1930 births 1996 deaths 20th-century biologists

Vita in brief

Mechanisms of regulation of rRNA synthesis

Science Heritage

See also

References

External links