Arvid Carlsson (25 January 1923 – 29 June 2018) was a

Swedish Swedish or ' may refer to: Anything from or related to Sweden, a country in Northern Europe. Or, specifically: * Swedish language, a North Germanic language spoken primarily in Sweden and Finland ** Swedish alphabet, the official alphabet used by ...

neuropharmacologist who is best known for his work with the neurotransmitter dopamine and its effects in

Parkinson's disease Parkinson's disease (PD), or simply Parkinson's, is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms usually emerge slowly, and as the disease worsens, non-motor symptoms becom ...

. For his work on dopamine, Carlsson was awarded the

Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, accord ...

in 2000, together with

Eric Kandel Eric Richard Kandel (; born Erich Richard Kandel, November 7, 1929) is an Austrian-born American medical doctor who specialized in psychiatry, a neuroscientist and a professor of biochemistry and biophysics at the College of Physicians and Surge ...

and

Paul Greengard Paul Greengard (December 11, 1925 – April 13, 2019) was an American neuroscientist best known for his work on the molecular and cellular function of neurons. In 2000, Greengard, Arvid Carlsson and Eric Kandel were awarded the Nobel Prize for ...

Early life and education

Carlsson was born on 25 January 1923 in

Uppsala Uppsala (, or all ending in , ; archaically spelled ''Upsala'') is the county seat of Uppsala County and the fourth-largest city in Sweden, after Stockholm, Gothenburg, and Malmö. It had 177,074 inhabitants in 2019. Located north of the c ...

, Sweden, one of four siblings. His family moved to Lund after his father became a history professor at

Lund University , motto = Ad utrumque , mottoeng = Prepared for both , established = , type = Public research university , budget = SEK 9 billion In 1944, he participated in the task of examining prisoners of Nazi concentration camps, whom Swedish aristocrat

Folke Bernadotte Folke Bernadotte, Count of Wisborg (2 January 1895 – 17 September 1948) was a Swedish nobleman and diplomat. In World War II he negotiated the release of about 31,000 prisoners from German concentration camps, including 450 Danish Jews fr ...

had managed to bring to Sweden, which was neutral during

World War II World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposin ...

. He received his MD and PhD in pharmacology in 1951.

Career

In 1951, Carlsson became an associate professor at Lund University. He spent five months as a research fellow for the pharmacologist

Bernard Beryl Brodie Bernard Beryl Brodie (7 August 1907 – 28 February 1989) was an English scientist. A leading researcher on drug therapy, he is considered by many to be the founder of modern pharmacology and brought the field to prominence in the 1940s an ...

at the

National Heart Institute The National Heart, Lung, and Blood Institute (NHLBI) is the third largest Institute of the National Institutes of Health, located in Bethesda, Maryland, United States. It is tasked with allocating about $3.6 billion in FY 2020 in tax revenue to ...

Bethesda, Maryland Bethesda () is an unincorporated, census-designated place in southern Montgomery County, Maryland. It is located just northwest of Washington, D.C. It takes its name from a local church, the Bethesda Meeting House (1820, rebuilt 1849), which in ...

, United States, and the change in his research focus to

psychopharmacology Psychopharmacology (from Greek grc, ψῡχή, psȳkhē, breath, life, soul, label=none; grc, φάρμακον, pharmakon, drug, label=none; and grc, -λογία, -logia, label=none) is the scientific study of the effects drugs have on mo ...

eventually led to his Nobel Prize. In 1959 he became a professor at the

University of Gothenburg The University of Gothenburg ( sv, Göteborgs universitet) is a university in Sweden's second largest city, Gothenburg. Founded in 1891, the university is the third-oldest of the current Swedish universities and with 37,000 students and 6000 st ...

. In 1957

Katharine Montagu Katharine Montagu was the first researcher to identify dopamine in human brains. Working in Hans Weil-Malherbe’s laboratory at the Runwell Hospital outside London the presence of dopamine was identified by paper chromatography in the brain of ...

demonstrated the presence of dopamine in the human brain; later that same year Carlsson also demonstrated that dopamine was a neurotransmitter in the

brain A brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. It is located in the head, usually close to the sensory organs for senses such as vision. It is the most complex organ in a ve ...

and not just a precursor for

norepinephrine Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as both a hormone and neurotransmitter. The name "noradrenaline" (from Latin '' ad' ...

. Carlsson went on to develop a method for measuring the amount of dopamine in brain tissues. He found that dopamine levels in the

basal ganglia The basal ganglia (BG), or basal nuclei, are a group of subcortical nuclei, of varied origin, in the brains of vertebrates. In humans, and some primates, there are some differences, mainly in the division of the globus pallidus into an exter ...

, a brain area important for movement, were particularly high. He then showed that giving animals the drug

reserpine Reserpine is a drug that is used for the treatment of high blood pressure, usually in combination with a thiazide diuretic or vasodilator. Large clinical trials have shown that combined treatment with reserpine plus a thiazide diuretic reduces m ...

caused a decrease in dopamine levels and a loss of movement control. These effects were similar to the symptoms of Parkinson's disease. By administering to these animals

L-Dopa -DOPA, also known as levodopa and -3,4-dihydroxyphenylalanine, is an amino acid that is made and used as part of the normal biology of some plants and animals, including humans. Humans, as well as a portion of the other animals that utilize -DOPA ...

, which is the precursor of dopamine, he could alleviate the symptoms. These findings led other doctors to try using L-Dopa in patients with Parkinson's disease, and it was found to alleviate some of the symptoms in the early stages of the disease. L-Dopa is still the basis for most commonly used means of treating Parkinson's disease. Carlson collaborated with the drug company Astra AB (now

AstraZeneca AstraZeneca plc () is a British-Swedish multinational pharmaceutical and biotechnology company with its headquarters at the Cambridge Biomedical Campus in Cambridge, England. It has a portfolio of products for major diseases in areas includin ...

) during the 1970s and the 1980s. He and his colleagues were able to derive the first marketed

selective serotonin reuptake inhibitor Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions. SSRIs increase the extracellul ...

(SSRI),

zimelidine Zimelidine (INN, BAN) (brand names Zimeldine, Normud, Zelmid) was one of the first selective serotonin reuptake inhibitor (SSRI) antidepressants to be marketed. It is a pyridylallylamine, and is structurally different from other antidepressants ...

, from

brompheniramine Brompheniramine, sold under the brand name Dimetapp among others, is a first-generation antihistamine drug of the propylamine (alkylamine) class. It is indicated for the treatment of the symptoms of the common cold and allergic rhinitis, such ...

. Zimelidine was later withdrawn from the market due to rare cases of

Guillain–Barré syndrome Guillain–Barré syndrome (GBS) is a rapid-onset muscle weakness caused by the immune system damaging the peripheral nervous system. Typically, both sides of the body are involved, and the initial symptoms are changes in sensation or pain oft ...

, but Carlson's research paved the way for fluoxetine (Prozac), one of the most widely used prescription medicines in the world. Carlsson was still an active researcher and speaker when he was over 90 years old and, together with his daughter Lena, he worked on OSU6162, a dopamine stabilizer which alleviates symptoms of post-stroke fatigue.

Honours and awards

Carlsson's research on the brain's chemical signals and the resulting treatment for Parkinson's disease earned him the 2000

, which he shared with

and Eric R. Kandel. He won many other awards including Israel's

Wolf Prize in Medicine The Wolf Prize in Medicine is awarded annually by the Wolf Foundation in Israel. It is one of the six Wolf Prizes established by the Foundation and awarded since 1978; the others are in Agriculture, Chemistry, Mathematics, Physics and Arts. The ...

(1979), the Japan Prize (1994), and Italy's

Feltrinelli Prize The Feltrinelli Prize (from the Italian "Premio Feltrinelli", also known as "International Feltrinelli Prize" or "Antonio Feltrinelli Prize") is an award for achievement in the arts, music, literature, history, philosophy, medicine, and physical and ...

(1999). He was elected as a member of the Royal Swedish Academy of Sciences in 1975.

Personal life

Carlsson married Ulla-Lisa Christoffersson in 1945 and they had three sons and two daughters. His daughter Maria was his lab manager and his daughter Lena was one of his collaborators. He opposed the

fluoridation Water fluoridation is the controlled adjustment of fluoride to a public water supply solely to reduce tooth decay. Fluoridated water contains fluoride at a level that is effective for preventing cavities; this can occur naturally or by addin ...

of drinking water in Sweden.Bryson C. (2004) ''The Fluoride Deception''. Seven Stories Press. p
p. 240
. He was a vocal opponent of homeopathy and worked to prevent homeopathic preparations from being classified as medication in Sweden. Carlsson died on 29 June 2018, at the age of 95.

References

External links

* including the Nobel Lecture 8 December 2000 ''A Half-Century of Neurotransmitter Research: Impact on Neurology and Psychiatry''
The Sahlgrenska Academy at the University of Gothenburg
{{DEFAULTSORT:Carlsson, Arvid 1923 births 2018 deaths Swedish neuroscientists Swedish pharmacologists Nobel laureates in Physiology or Medicine People connected to Lund University Wolf Prize in Medicine laureates Swedish Nobel laureates University of Gothenburg faculty Members of the Royal Swedish Academy of Sciences People from Uppsala 20th-century Swedish scientists 21st-century Swedish scientists Members of the National Academy of Medicine