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Arthur Fernandez Coca (20 March 1875 – 11 December 1959) was an American immunologist known for his research on
allergies Allergies, also known as allergic diseases, refer a number of conditions caused by the hypersensitivity of the immune system to typically harmless substances in the environment. These diseases include hay fever, food allergies, atopic derma ...
.


Biography

Coca was born in
Philadelphia Philadelphia, often called Philly, is the largest city in the Commonwealth of Pennsylvania, the sixth-largest city in the U.S., the second-largest city in both the Northeast megalopolis and Mid-Atlantic regions after New York City. Sinc ...
. He was educated at
Haverford College Haverford College ( ) is a private liberal arts college in Haverford, Pennsylvania. It was founded as a men's college in 1833 by members of the Religious Society of Friends (Quakers), began accepting non-Quakers in 1849, and became coeducational ...
and obtained his M.D. from
University of Pennsylvania The University of Pennsylvania (also known as Penn or UPenn) is a private research university in Philadelphia. It is the fourth-oldest institution of higher education in the United States and is ranked among the highest-regarded universitie ...
in 1900. He studied at
Heidelberg University } Heidelberg University, officially the Ruprecht Karl University of Heidelberg, (german: Ruprecht-Karls-Universität Heidelberg; la, Universitas Ruperto Carola Heidelbergensis) is a public research university in Heidelberg, Baden-Württemberg, ...
and during 1907–1909 was an assistant to
Emil von Dungern Baron Emil von Dungern (26 November 1867 – 4 September 1961) was a German internist. Von Dungern was born in Würzburg and died in Ludwigshafen am Bodensee. In 1910–11, E. von Dungern and Ludwik Hirszfeld discovered the heritability of ...
at the Cancer Institute of Heidelberg's chemical laboratory. He worked as a bacteriologist at the Bureau of Science in Manila and was instructor in Pathology and Bacteriology at
Cornell University Medical College The Joan & Sanford I. Weill Medical College of Cornell University is Cornell University's biomedical research unit and medical school located in Upper East Side, Manhattan, New York City, New York. Weill Cornell Medicine is affiliated with New ...
during 1910–1919. He was Professor of Immunology and Professor of Medicine at the New York Postgraduate Medical School,
Columbia University Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...
from 1924 to 1935. He was also medical director of
Lederle Laboratories American Cyanamid Company was a leading American conglomerate which became one of the nation's top 100 manufacturing companies during the 1970s and 1980s, according to the Fortune 500 listings at the time. It started in fertilizer, but added m ...
until 1949. Coca specialized in studying
allergies Allergies, also known as allergic diseases, refer a number of conditions caused by the hypersensitivity of the immune system to typically harmless substances in the environment. These diseases include hay fever, food allergies, atopic derma ...
. He has been described as one of the pioneers of allergology. In 1953, he authored the book ''Familial Nonreaginic Food-Allergy''. Coca and Robert Cooke coined the term
atopy Atopy is the tendency to produce an exaggerated immunoglobulin E (IgE) immune response to otherwise harmless substances in the environment. Allergic diseases are clinical manifestations of such inappropriate, atopic responses. Atopy may have a ...
in 1923 when recognizing an association between allergic rhinitis and asthma. Science historian
Arthur M. Silverstein Arthur M. Silverstein is an American immunologist and science historian who has written extensively on the history of immunology. He is Professor Emeritus of Ophthalmic Immunology at the Johns Hopkins School of Medicine, where he spent 25 years on ...
has noted that Coca contributed "significantly to the development of allergy as a scientific discipline".Silverstein, Arthur M. (2012). ''A History of Immunology''. Elsevier Science. p. 226. Coca attempted to classify
hypersensitive ''Hypersensitive'' is the second album by American rock band Ghost Machine. It was released on November 21, 2006 via Corporate Punishment Records. The original track listing of the album, displayed on sites like Amazon and AllMusic AllMus ...
states to conditions such as dermatosis, hay fever and
serum sickness Serum sickness in humans is a reaction to proteins in antiserum derived from a non-human animal source, occurring 5–10 days after exposure. Symptoms often include a rash, joint pain, fever, and lymphadenopathy. It is a type of hypersensitivity, ...
. Coca and Robert Cooke founded the Society of Asthma and Allied Conditions in 1924. Coca also founded the Allergy Roundtable Discussion Group in New York. Coca founded ''
The Journal of Immunology The ''Journal of Immunology'' is a biweekly peer-reviewed medical journal that publishes basic and clinical studies in all aspects of immunology. Established in 1916, it changed its name to ''Journal of Immunology, Virus Research and Experimental ...
'' and was its editor from 1916 to 1948."Arthur F. Coca, M.D."
aai.org. Retrieved 26 February 2022.
He was Honorary President of the
American Association of Immunologists The American Association of Immunologists (AAI) is an international scientific society dedicated to furthering the study of immunology. AAI provides its members with a variety of platforms in which to exchange ideas and present the latest immunolo ...
, a position he held from 1949 until his death.


Pulse test

Coca developed a new method to diagnose allergies by testing his patients
pulse In medicine, a pulse represents the tactile arterial palpation of the cardiac cycle (heartbeat) by trained fingertips. The pulse may be palpated in any place that allows an artery to be compressed near the surface of the body, such as at the nec ...
rate, known as the "pulse test". He wrote about it in his book ''The Pulse Test: Easy Allergy Detection'', first published in 1956.Hall, Harriet. (2018)
"Coca’s Pulse Testing to Diagnose “Allergies”"
''
Science-Based Medicine ''Science-Based Medicine'' is a website and blog with articles covering issues in science and medicine, especially medical scams and practices. Founded in 2008, it is owned and operated by the New England Skeptical Society and run by Steven N ...
''. Retrieved 26 February 2022.
Coca argued that hidden food allergies are the cause of almost every disease and disorder including heart attacks, asthma, constipation, diabetes, epilepsy, hypertension, indigestion, migraine and many others. He stated that the pulse test could help his patients identify which foods they were allergic to. For example, if the pulse rises after eating a certain food, then this means the patient is allergic to that food. Coca did not offer any scientific evidence for his pulse test and it was dismissed by the scientific community but later promoted by
alternative medicine Alternative medicine is any practice that aims to achieve the healing effects of medicine despite lacking biological plausibility, testability, repeatability, or evidence from clinical trials. Complementary medicine (CM), complementary and alt ...
websites.
Harriet Hall Harriet A. Hall (born July 2, 1945) is a U.S. retired family physician, former U.S. Air Force flight surgeon and skeptic who writes about alternative medicine and quackery for ''Skeptic'' and ''Skeptical Inquirer''. She writes under the name The ...
has commented that Coca "never put his beliefs to any kind of a valid scientific test... Many factors affect the pulse rate, and when patients are aware that a food is being tested, anxiety, excitement, and other factors could affect the pulse rate. There are just too many variables for the pulse test to be a reliable indicator of anything."


Selected publications

*''Familial Nonreaginic Food-Allergy'' (1953)
''The Pulse Test: Easy Allergy Detection''
(1956, 1959) *''The Pulse Test: The Secret of Building Your Basic Health'' (1995)


References

{{DEFAULTSORT:Coca, Arthur F. 1875 births 1959 deaths Allergologists American immunologists American medical writers Columbia University staff Heidelberg University alumni Physicians from Philadelphia University of Pennsylvania alumni