Arthur Felix, FRS (3 April 1887 in

Andrychów Andrychów ( la, Andrichovia, list=no, german: Andrichau, list=no, hist. also ''Andrychau'') is the largest town in Wadowice County, Lesser Poland Voivodeship, Poland. The town is located in the Little Beskids, in the historical region of Lesse ...

– 17 January 1956 in

England England is a country that is part of the United Kingdom. It shares land borders with Wales to its west and Scotland to its north. The Irish Sea lies northwest and the Celtic Sea to the southwest. It is separated from continental Europe b ...

) was a Polish-born

microbiologist A microbiologist (from Ancient Greek, Greek ) is a scientist who studies microscopic life forms and processes. This includes study of the growth, interactions and characteristics of Microorganism, microscopic organisms such as bacteria, algae, f ...

and serologist.

Education and early life

Arthur Felix was the son of Theodor Felix, who had an interest in printed textiles and who encouraged his son to study textile dye chemistry. Felix studied chemistry in Vienna and was awarded a

Doctor of Science Doctor of Science ( la, links=no, Scientiae Doctor), usually abbreviated Sc.D., D.Sc., S.D., or D.S., is an academic research degree awarded in a number of countries throughout the world. In some countries, "Doctor of Science" is the degree used f ...

degree. After working in his father's textile printing factory, he returned to Vienna to study

microbiology Microbiology () is the scientific study of microorganisms, those being unicellular (single cell), multicellular (cell colony), or acellular (lacking cells). Microbiology encompasses numerous sub-disciplines including virology, bacteriology, prot ...

. Arthus Felix was

Jewish Jews ( he, יְהוּדִים, , ) or Jewish people are an ethnoreligious group and nation originating from the Israelites Israelite origins and kingdom: "The first act in the long drama of Jewish history is the age of the Israelites""The ...

; he became interested in Zionism during his student days in Vienna and later developed into an authority on Palestine.

Career

In 1915, Arthur Felix and Edmund Weil were Austrian medical officers working in a field laboratory in

Sokal Sokal ( uk, Сокаль, romanized: ''Sokal'') is a city located on the Bug River in Chervonohrad Raion, Lviv Oblast of western Ukraine. It hosts the administration of Sokal urban hromada, one of the hromadas of Ukraine. The population is appro ...

and discovered a

bacillus ''Bacillus'' (Latin "stick") is a genus of Gram-positive, rod-shaped bacteria, a member of the phylum ''Bacillota'', with 266 named species. The term is also used to describe the shape (rod) of other so-shaped bacteria; and the plural ''Bacilli ...

in the

urine Urine is a liquid by-product of metabolism in humans and in many other animals. Urine flows from the kidneys through the ureters to the urinary bladder. Urination results in urine being excretion, excreted from the body through the urethra. Cel ...

of patients with

typhus Typhus, also known as typhus fever, is a group of infectious diseases that include epidemic typhus, scrub typhus, and murine typhus. Common symptoms include fever, headache, and a rash. Typically these begin one to two weeks after exposure. ...

. They developed the

Weil–Felix test The Weil–Felix test is an agglutination test for the diagnosis of rickettsial infections. It was first described in 1916. By virtue of its long history and of its simplicity, it has been one of the most widely employed tests for rickettsia on a g ...

for diagnosis of typhus and other

rickettsia ''Rickettsia'' is a genus of nonmotile, gram-negative, nonspore-forming, highly pleomorphic bacteria that may occur in the forms of cocci (0.1 μm in diameter), bacilli (1–4 μm long), or threads (up to about 10 μm long). The term "rickett ...

l diseases. The use of the O and H symbols in the

Kauffman–White classification The Kauffmann–White classification or Kauffmann and White classification scheme is a system that classifies the genus ''Salmonella'' into serotypes, based on surface antigens. It is named after Philip Bruce White and Fritz Kauffmann. First the ...

originates from the research by Edmund Weil and Arthur Felix. In 1934, Felix identified the Vi

antigen In immunology, an antigen (Ag) is a molecule or molecular structure or any foreign particulate matter or a pollen grain that can bind to a specific antibody or T-cell receptor. The presence of antigens in the body may trigger an immune response. ...

in patients with

typhoid fever Typhoid fever, also known as typhoid, is a disease caused by '' Salmonella'' serotype Typhi bacteria. Symptoms vary from mild to severe, and usually begin six to 30 days after exposure. Often there is a gradual onset of a high fever over several ...

. The discovery of Vi antigen was done in collaboration with Miss S. R. Margaret Pitt. Miss Pitt co-authored many publications with Felix throughout her career, although not much is known about her as misogyny kept her from the proper recognition she deserved as a scientist. Felix and Pitt isolated the

Salmonella Typhi ''Salmonella enterica'' subsp. ''enterica'' is a subspecies of ''Salmonella enterica'', the rod-shaped, flagellated, aerobic, Gram-negative bacterium. Many of the pathogenic serovars of the ''S. enterica'' species are in this subspecies, includin ...

strain Ty2, which is still in use in laboratory research today. Ty2 was the basis for the

Ty21a Ty21a is a live attenuated bacterial vaccine that protects against typhoid. First licensed in Europe in 1983 and in the United States in 1989, it is an orally administered, live-attenuated Ty2 strain of S. Typhi in which multiple genes, includin ...

vaccine strain, a live attenuated strain used to protect patients from typhoid fever today. Ty2 was isolated from a patient in

Kherson Kherson (, ) is a port city of Ukraine Ukraine ( uk, Україна, Ukraïna, ) is a country in Eastern Europe. It is the second-largest European country after Russia, which it borders to the east and northeast. Ukraine covers appr ...

in 1918. Ty2 was investigated due to its ability to avoid agglutination in rabbit serum, which Felix and Pitt later determined was due to the production of Vi capsule which inhibits binding of O antigen. He and Pitt also then went on to discover antigens present in Paratyphi A and B. He also co-authored a comprehensive review of what was known about typhoid fever and diagnosis with another female scientist, Miss M. Rhodes. Much of the foundational knowledge about

pathology, diagnosis of typhoid fever, and the foundational work that lead to the two typhoid vaccines in use today are contributed by Dr. Felix and his colleagues. After

World War I World War I (28 July 1914 11 November 1918), often abbreviated as WWI, was one of the deadliest global conflicts in history. Belligerents included much of Europe, the Russian Empire, the United States, and the Ottoman Empire, with fightin ...

, Felix emigrated to Britain and worked at the

Lister Institute The Lister Institute of Preventive Medicine, informally known as the Lister Institute, was established as a research institute (the British Institute of Preventive Medicine) in 1891, with bacteriologist Marc Armand Ruffer as its first director, us ...

. Felix researched in

Bielsko Bielsko (german: Bielitz, cs, Bílsko) was until 1950 an independent town situated in Cieszyn Silesia, Poland. In 1951 it was joined with Biała Krakowska to form the new town of Bielsko-Biała. Bielsko constitutes the western part of that tow ...

Vienna en, Viennese , iso_code = AT-9 , registration_plate = W , postal_code_type = Postal code , postal_code = , timezone = CET , utc_offset = +1 , timezone_DST ...

Prague Prague ( ; cs, Praha ; german: Prag, ; la, Praga) is the capital and largest city in the Czech Republic, and the historical capital of Bohemia. On the Vltava river, Prague is home to about 1.3 million people. The city has a temperate ...

, and

London London is the capital and largest city of England and the United Kingdom, with a population of just under 9 million. It stands on the River Thames in south-east England at the head of a estuary down to the North Sea, and has been a majo ...

. Between 1927 and 1945, he worked in

Jerusalem Jerusalem (; he, יְרוּשָׁלַיִם ; ar, القُدس ) (combining the Biblical and common usage Arabic names); grc, Ἱερουσαλήμ/Ἰεροσόλυμα, Hierousalḗm/Hierosóluma; hy, Երուսաղեմ, Erusałēm. i ...

for the

Hadassah Medical Organization Hadassah Medical Center ( he, הָמֶרְכָּז הָרְפוּאִי הֲדַסָּה) is an Israeli medical organization established in 1934 that operates two university hospitals in Jerusalem – one in Ein Karem and one in Mount Scopus –, ...

Awards and honours

In 1943 he was elected a

Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the judges of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural science, natural knowledge, incl ...

References

{{DEFAULTSORT:Felix, Arthur 1887 births 1956 deaths 19th-century Polish Jews Polish microbiologists Fellows of the Royal Society Polish emigrants to the United Kingdom