Lumefantrine (or benflumetol) is an

antimalarial drug Antimalarial medications or simply antimalarials are a type of antiparasitic chemical agent, often naturally derived, that can be used to treat or to prevent malaria, in the latter case, most often aiming at two susceptible target groups, young c ...

. It is only used in

combination In mathematics, a combination is a selection of items from a set that has distinct members, such that the order of selection does not matter (unlike permutations). For example, given three fruits, say an apple, an orange and a pear, there are th ...

with

artemether Artemether is a medication used for the treatment of malaria. The injectable form is specifically used for severe malaria rather than quinine. In adults, it may not be as effective as artesunate. It is given by injection in a muscle. It is also a ...

. The term "co-artemether" is sometimes used to describe this combination. Lumefantrine has a much longer half-life compared to artemether, and is therefore thought to clear any residual parasites that remain after combination treatment. Lumefantrine, along with

pyronaridine Pyronaridine is an antimalarial drug. It was first made in 1970 and has been in clinical use in China since the 1980s. In a small (n=88) malaria study in Camaroon, pyronaridine had a 100% cure rate, compared with 60% for chloroquine. It is one ...

and naphtoquine, were synthesized during the Chinese

Project 523 Project 523 (or task number five hundred and twenty-three; ) is a code name for a 1967 secret military project of the People's Republic of China to find antimalarial medications. Named after the date the project launched, 23 May, it addressed mala ...

antimalaria drug research effort initiated in 1967; these compounds are all used in combination antimalaria therapies.

References

Secondary alcohols Amines Antimalarial agents Chinese discoveries Chlorobenzenes CYP2D6 inhibitors Fluorenes Phenylethanolamines Butyl compounds {{antiinfective-drug-stub

See also

References