Arotinolol (

INN Inns are generally establishments or buildings where travelers can seek lodging, and usually, food and drink. Inns are typically located in the country or along a highway; before the advent of motorized transportation they also provided accommo ...

, marketed under the tradename Almarl) is a

medication A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy (pharmacotherapy) is an important part of the medical field and re ...

in the class of mixed

alpha Alpha (uppercase , lowercase ; grc, ἄλφα, ''álpha'', or ell, άλφα, álfa) is the first letter of the Greek alphabet. In the system of Greek numerals, it has a value of one. Alpha is derived from the Phoenician letter aleph , whic ...

beta blocker Beta blockers, also spelled β-blockers, are a class of medications that are predominantly used to manage cardiac arrhythmia, abnormal heart rhythms, and to protect the heart from a second myocardial infarction, heart attack after a first heart ...

s. It also acts as a β₃ receptor

agonist An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...

. A 1979 publication suggests arotinolol as having first been described in the scientific literature by

Sumitomo Chemical is a major Japanese chemical company. The company is listed on the first section of the Tokyo Stock Exchange and is a constituent of the on the Nikkei 225 stock index. It's a member of the Sumitomo group and was founded in 1913 as a fertilize ...

as "β-adrenergic blocking, antiarrhythmic compound S-596".

Medical uses

It is used in the treatment of

high blood pressure Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long-term medical condition in which the blood pressure in the arteries is persistently elevated. High blood pressure usually does not cause symptoms. Long-term high bl ...

and

essential tremor Essential tremor (ET), also called benign tremor, familial tremor, and idiopathic tremor, is a medical condition characterized by involuntary rhythmic contractions and relaxations ( oscillations or twitching movements) of certain muscle groups in ...

. Recommended dosage is 10 to 30 mg per day.

References

External links

*
Almarl Full Prescribing Information. Revised November 2009
Sumitomo Dainippon Pharma Co., Ltd. *
Official Sumitomo Dainippon Pharma Website
* {{Adrenergic receptor modulators Alpha-1 blockers Amines Beta blockers Beta3-adrenergic agonists Carboxamides Secondary alcohols Tert-butyl compounds Thiazoles Thioethers Thiophenes