The Arens–van Dorp synthesis is a
name reaction A name reaction is a chemical reaction named after its discoverers or developers. Among the tens of thousands of organic reactions that are known, hundreds of such reactions are well-known enough to be named after people. Well-known examples include ...
in
organic chemistry
Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms that contain carbon atoms.Clayden, J.; ...
. It describes the addition of lithiated ethoxyacetylenes to
ketones
In organic chemistry, a ketone is a functional group with the structure R–C(=O)–R', where R and R' can be a variety of carbon-containing substituents. Ketones contain a carbonyl group –C(=O)– (which contains a carbon-oxygen double bon ...
to give propargyl alcohols, which can undergo further reaction to form α,β-unsaturated aldehydes, or esters. There is also a variation of this reaction called the Isler modification, where the acetylide anion is generated in situ from β-chlorovinyl ether using
lithium amide
Lithium amide or lithium azanide is an inorganic compound with the chemical formula . It is a white solid with a tetragonal crystal structure. Lithium amide can be made by treating lithium metal with liquid ammonia:
:
Other lithium amides
The co ...
.
References
{{DEFAULTSORT:Arens-van Dorp synthesis
Name reactions
Chemistry
Organic chemistry