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Archaeosine synthase (, ''ArcS'', ''TgtA2'', ''MJ1022 (gene)'', ''glutamine:preQ0-tRNA amidinotransferase'') is an
enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
with systematic name ''L-glutamine:7-cyano-7-carbaguanine aminotransferase''. This enzyme catalyses the following
chemical reaction A chemical reaction is a process that leads to the IUPAC nomenclature for organic transformations, chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the pos ...
: L- glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O \rightleftharpoons L-
glutamate Glutamic acid (symbol Glu or E; the ionic form is known as glutamate) is an α-amino acid that is used by almost all living beings in the biosynthesis of proteins. It is a non-essential nutrient for humans, meaning that the human body can syn ...
+ archaeine15 in tRNA In Euryarchaeota the reaction is catalysed by ArcS.


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* {{Portal bar, Biology, border=no EC 2.6.1