Arachidonylcyclopropylamide (ACPA) is a synthetic agonist of the

cannabinoid receptor 1 Cannabinoid receptor type 1 (CB1), also known as cannabinoid receptor 1, is a G protein-coupled cannabinoid receptor that in humans is encoded by the ''CNR1'' gene. The human CB1 receptor is expressed in the peripheral nervous system and central ...

(CB1R). ACPA is considered to be a selective cannabinoid

agonist An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...

as it binds primarily to the CB1R and has low affinity to the

cannabinoid receptor 2 The cannabinoid receptor type 2, abbreviated as CB2, is a G protein-coupled receptor from the cannabinoid receptor family that in humans is encoded by the ''CNR2'' gene. It is closely related to the cannabinoid receptor type 1 (CB1), which is la ...

(CB2R) ( K_i = 2.2 nM for CB1R; K_i = 700 nM for CB2R).

References

{{Cannabinoids Fatty acid amides Cannabinoids Cyclopropanes