Apolipoprotein L (Apo L) is found in high-density lipoprotein complexes that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and

signal transduction Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellula ...

both in the adult brain and during

neurodevelopment The development of the nervous system in humans, or neural development or neurodevelopment involves the studies of embryology, developmental biology, and neuroscience to describe the cellular and molecular mechanisms by which the complex nervous ...

. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for

schizophrenia Schizophrenia is a mental disorder characterized by continuous or relapsing episodes of psychosis. Major symptoms include hallucinations (typically hearing voices), delusions, and disorganized thinking. Other symptoms include social withdra ...

and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.

Human proteins containing this domain

APOL1 Apolipoprotein L1 is a protein that in humans is encoded by the ''APOL1'' gene. Two transcript variants encoding two different isoforms have been found for this gene. Species distribution This gene is found only in humans, African green monkeys ...

; APOL2; APOL3; APOL4; APOL5; APOL6; APOLD1;

References

{{Lipoproteins Apolipoproteins Protein domains Protein families