Anti-Scl-70 (also called anti-topoisomerase I after the
type I topoisomerase
In molecular biology Type I topoisomerases are enzymes that cut one of the two strands of double-stranded DNA, relax the strand, and reanneal the strand. They are further subdivided into two structurally and mechanistically distinct topoisomerase ...
target
) is an
anti-topoisomerase antibody-type of
anti-nuclear autoantibodies, seen mainly in diffuse
systemic scleroderma (with a
sensitivity
Sensitivity may refer to:
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* Sensitivity (physiology), the ability of an organism or organ to respond to external stimuli
** Sensory processing sensitivity in humans
* Sensitivity and specificity, statisti ...
of 28–70%), but is also seen in 10–18% of cases of the more limited form of systemic scleroderma called
CREST syndrome.
[Table 5-9 in: 8th edition.] Anti Scl-70 antibodies are associated with more severe scleroderma disease.
The etymology of scl-70 consists of an abbreviation of scleroderma and a 70
kD extractable immunoreactive fragment that can be obtained from the otherwise larger (100–105 kD) target topoisomerase
antigen (called the SCL-70 Antigen) of the antibodies.
Product Name: SCL-70 Antigen
at ImmunoVision.com, retrieved April 2011
References
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Autoantibodies