Anti-Scl-70 (also called anti-topoisomerase I after the
type I topoisomerase
In molecular biology Type I topoisomerases are enzymes that cut one of the two strands of double-stranded DNA, relax the strand, and reanneal the strand. They are further subdivided into two structurally and mechanistically distinct topoisomerase ...
target
) is an
anti-topoisomerase antibody
Anti-topoisomerase antibodies (ATA) are autoantibodies directed against topoisomerase and found in several diseases, most importantly scleroderma. Diseases with ATA are autoimmune disease because they react with self-proteins. They are also referr ...
-type of
anti-nuclear autoantibodies
Antinuclear antibodies (ANAs, also known as antinuclear factor or ANF) are autoantibodies that bind to contents of the cell nucleus. In normal individuals, the immune system produces antibodies to foreign proteins (antigens) but not to human prote ...
, seen mainly in diffuse
systemic scleroderma
Systemic scleroderma, or systemic sclerosis, is an autoimmune rheumatic disease characterised by excessive production and accumulation of collagen, called fibrosis, in the skin and internal organs and by injuries to small arteries. There are two m ...
(with a
sensitivity of 28–70%), but is also seen in 10–18% of cases of the more limited form of systemic scleroderma called
CREST syndrome
CREST syndrome, also known as the limited cutaneous form of systemic sclerosis (lcSSc), is a multisystem connective tissue disorder. The acronym "CREST" refers to the five main features: calcinosis, Raynaud's phenomenon, esophageal dysmotility, ...
.
[Table 5-9 in: 8th edition.] Anti Scl-70 antibodies are associated with more severe scleroderma disease.
The etymology of scl-70 consists of an abbreviation of scleroderma and a 70
kD extractable immunoreactive fragment that can be obtained from the otherwise larger (100–105 kD) target topoisomerase
antigen
In immunology, an antigen (Ag) is a molecule or molecular structure or any foreign particulate matter or a pollen grain that can bind to a specific antibody or T-cell receptor. The presence of antigens in the body may trigger an immune response. ...
(called the SCL-70 Antigen) of the antibodies.
Product Name: SCL-70 Antigen
at ImmunoVision.com, retrieved April 2011
References
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Autoantibodies