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Anne Elisabeth Osbourn is a professor of biology and group leader at the
John Innes Centre The John Innes Centre (JIC), located in Norwich, Norfolk, England, is an independent centre for research and training in plant and microbial science founded in 1910. It is a registered charity (No 223852) grant-aided by the Biotechnology and ...
, where she investigates plant natural product biosynthesis. She discovered that in the plant genome, the genes involved with biosynthesis organise in clusters. She is also a popular science communicator, poet and is the founder of th
Science, Art and Writing (SAW)
Initiative. She was elected a member of the National Academy of Sciences in 2022.


Early life and education

Osbourn grew up in
West Yorkshire West Yorkshire is a metropolitan and ceremonial county in the Yorkshire and Humber Region of England. It is an inland and upland county having eastward-draining valleys while taking in the moors of the Pennines. West Yorkshire came into exi ...
. Her parents both studied and lectured English literature and her father served in the army during
World War II World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposing ...
. She became interested in plants as a child and she attended
Bingley Grammar School Bingley Grammar School (BGS) is a Voluntary aided school for students from the ages of 11–18 and is located on the outskirts of Bingley, West Yorkshire, England. Bingley Grammar School was a specialist school for Business & Enterprise from ...
graduating in 1979. She earned a bachelor's degree in
botany Botany, also called , plant biology or phytology, is the science of plant life and a branch of biology. A botanist, plant scientist or phytologist is a scientist who specialises in this field. The term "botany" comes from the Ancient Greek w ...
at Durham University in 1982. At this time, researchers worked out how to transform the ''
Rhizobium ''Rhizobium'' is a genus of Gram-negative soil bacteria that fix nitrogen. ''Rhizobium'' species form an endosymbiotic nitrogen-fixing association with roots of (primarily) legumes and other flowering plants. The bacteria colonize plant cells ...
''
nitrogen fixation Nitrogen fixation is a chemical process by which molecular nitrogen (), with a strong triple covalent bond, in the air is converted into ammonia () or related nitrogenous compounds, typically in soil or aquatic systems but also in industry. Atmo ...
genes into the bacterium ''
Escherichia coli ''Escherichia coli'' (),Wells, J. C. (2000) Longman Pronunciation Dictionary. Harlow ngland Pearson Education Ltd. also known as ''E. coli'' (), is a Gram-negative, facultative anaerobic, rod-shaped, coliform bacterium of the genus '' Esc ...
''. Osbourn moved to the
University of Birmingham The University of Birmingham (informally Birmingham University) is a Public university, public research university located in Edgbaston, Birmingham, United Kingdom. It received its royal charter in 1900 as a successor to Queen's College, Birmingha ...
for her doctoral studies on
host adaptation When considering pathogens, host adaptation can have varying descriptions. For example, in the case of ''Salmonella'', host adaptation is used to describe the "ability of a pathogen to circulate and cause disease in a particular host population." An ...
in '' Septoria nodorum'', supervised by Chris Caten. She has described the
Salem State University Salem State University (Salem State or SSU) is a public university in Salem, Massachusetts. Established in 1854, it is the oldest and largest institute of higher education on the North Shore and is part of the state university system in Massa ...
educationalist Louise Swiniarksi as her 'anchor throughout my adult life'.


Research and career

Osbourn moved to
Norwich Norwich () is a cathedral city and district of Norfolk, England, of which it is the county town. Norwich is by the River Wensum, about north-east of London, north of Ipswich and east of Peterborough. As the seat of the See of Norwich, with ...
in 1985 to work as a post-doctoral researcher at the
John Innes Centre The John Innes Centre (JIC), located in Norwich, Norfolk, England, is an independent centre for research and training in plant and microbial science founded in 1910. It is a registered charity (No 223852) grant-aided by the Biotechnology and ...
. In 1987 she joined The Sainsbury Laboratory as a Research Fellow, and she became a group leader in 1999. In 2005 she re-joined the
John Innes Centre The John Innes Centre (JIC), located in Norwich, Norfolk, England, is an independent centre for research and training in plant and microbial science founded in 1910. It is a registered charity (No 223852) grant-aided by the Biotechnology and ...
as a group leader, and was appointed head of the Department for Metabolic Biology in 2006. Her early work looked at
saponins Saponins (Latin "sapon", soap + "-in", one of), also selectively referred to as triterpene glycosides, are bitter-tasting usually toxic plant-derived organic chemicals that have a foamy quality when agitated in water. They are widely distributed ...
and their role in plant defence. Osbourn studies how natural products interact with natural organisms. In particular, she has worked on the biosynthesis of
triterpene Triterpenes are a class of chemical compounds composed of three terpene units with the molecular formula C30H48; they may also be thought of as consisting of six isoprene units. Animals, plants and fungi all produce triterpenes, including squa ...
. She identified that metabolic pathways organise in
operon In genetics, an operon is a functioning unit of DNA containing a cluster of genes under the control of a single promoter. The genes are transcribed together into an mRNA strand and either translated together in the cytoplasm, or undergo splic ...
-like clusters, which allowed her to develop a novel opportunity to discover natural product pathways through genome mining. The
natural products A natural product is a natural compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life. Natural products can also be prepared by chemical sy ...
include
terpenes Terpenes () are a class of natural products consisting of compounds with the formula (C5H8)n for n > 1. Comprising more than 30,000 compounds, these unsaturated hydrocarbons are produced predominantly by plants, particularly conifers. Terpenes ar ...
, which can be used in the
pharmaceutical industry The pharmaceutical industry discovers, develops, produces, and markets drugs or pharmaceutical drugs for use as medications to be administered to patients (or self-administered), with the aim to cure them, vaccinate them, or alleviate symptoms. ...
as well as food and manufacturing. Her research has been funded by the Biotechnology and Biological Sciences Research Council (BBSRC). In 2006, Osbourn became an Honorary Professor at the
University of East Anglia The University of East Anglia (UEA) is a public research university in Norwich, England. Established in 1963 on a campus west of the city centre, the university has four faculties and 26 schools of study. The annual income of the institution f ...
. Since 2014 she has been the director of the OpenPlant Synthetic Biology Research Centre, a
BBSRC Biotechnology and Biological Sciences Research Council (BBSRC), part of UK Research and Innovation, is a non-departmental public body (NDPB), and is the largest UK public funder of non-medical bioscience. It predominantly funds scientific rese ...
and
EPSRC The Engineering and Physical Sciences Research Council (EPSRC) is a British Research Council that provides government funding for grants to undertake research and postgraduate degrees in engineering and the physical sciences, mainly to univers ...
-funded
Synthetic Biology Synthetic biology (SynBio) is a multidisciplinary area of research that seeks to create new biological parts, devices, and systems, or to redesign systems that are already found in nature. It is a branch of science that encompasses a broad ran ...
Research Centre led jointly by the John Innes Centre and the University of Cambridge. The Cambridge-based Director is Professor Jim Haseloff and the formal lead is Professor Sir David Baulcombe. She was the Director of the Norwich Research Park Industrial Biotechnology Alliance from 2013 to 2019. As a group leader at the John Innes Centre she leads a research group working on plant natural products, their biosynthesis, function, mechanisms of metabolic diversification and metabolic engineering.


Public engagement

In 2004, Osbourn was appointed to the
UEA Creative Writing Course The University of East Anglia's Creative Writing Course was founded by Sir Malcolm Bradbury and Sir Angus Wilson in 1970. The M.A. is widely regarded as the most prestigious and successful in the country and competition for places is notoriously ...
as a
Nesta Nesta (formerly NESTA, National Endowment for Science, Technology and the Arts) is an innovation foundation based in the UK. The organisation acts through a combination of programmes, investment, policy and research, and the formation of part ...
dreamtime fellow. Here she wrote poetry about her life as a plant scientist. Since then Osbourn has become a popular science writer, and inspired by her own creative practice she founded the Science, Art and Writing (SAW) Trust in 2005. The SAW Trust is an international charity that promotes innovation in science communication, and works with young people from elementary schools in initiatives which bring together scientists, writers and artists to explore creative science communication initiatives. The SAW Trust, working with educational bureaus and schools in China, has built an extensive educational programme for schools. Over 1,000 children have now taken part in SAW projects in schools in China. In 2016 Osbourn took part in an international exchange with the Vietnam Academy of Science and Technology.


Honours and Editorial positions

Osbourn was elected to AcademiaNet in 2014. She is an editor of the ''
New Phytologist ''New Phytologist'' is a peer-reviewed scientific journal published on behalf of the New Phytologist Foundation by Wiley-Blackwell. It was founded in 1902 by botanist Arthur Tansley, who served as editor until 1931. Topics covered ''New Phytolo ...
'' and is on the editorial board of '' Molecular Plant''. She has won various awards and honours, including the medal of the
University of Helsinki The University of Helsinki ( fi, Helsingin yliopisto, sv, Helsingfors universitet, abbreviated UH) is a public research university located in Helsinki, Finland since 1829, but founded in the city of Turku (in Swedish ''Åbo'') in 1640 as the ...
in 2003. In 2018 she was elected a Fellow of the
Linnean Society The Linnean Society of London is a learned society dedicated to the study and dissemination of information concerning natural history, evolution, and taxonomy. It possesses several important biological specimen, manuscript and literature colle ...
, and in 2019 Osbourn was elected as a
Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the judges of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural knowledge, including mathemat ...
(FRS). She is the thirtieth research who has been elected Fellow from the
John Innes Centre The John Innes Centre (JIC), located in Norwich, Norfolk, England, is an independent centre for research and training in plant and microbial science founded in 1910. It is a registered charity (No 223852) grant-aided by the Biotechnology and ...
. She was appointed Officer of the Order of the British Empire (OBE) in the 2020 New Year Honours for services to plant science.


Patents

* 2011 Root-specific promoters * 2008 Enzymes involved in triterpene synthesis


References

{{DEFAULTSORT:Osbourn, Anne Alumni of the University of Birmingham English botanists British women botanists Fellows of the Royal Society Alumni of Van Mildert College, Durham Year of birth missing (living people) Living people Officers of the Order of the British Empire Female Fellows of the Royal Society Members of the United States National Academy of Sciences