Anion exchange protein 2 (AE2) is a
membrane transport protein that in humans is encoded by the ''SLC4A2''
gene.
AE2 is functionally similar to the
Band 3 Cl−/
HCO3− exchange protein.
Mice
A mouse ( : mice) is a small rodent. Characteristically, mice are known to have a pointed snout, small rounded ears, a body-length scaly tail, and a high breeding rate. The best known mouse species is the common house mouse (''Mus musculus' ...
have been used to explore the function of AE2. AE2 contributes to
basolateral membrane HCO
3− transport in the
gastrointestinal tract
The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the digestive system that leads from the mouth to the anus. The GI tract contains all the major organ (biology), organs of the digestive syste ...
.
AE2 is required for
spermiogenesis in mice.
AE2 is required for normal
osteoclast function.
The activity of AE2 is sensitive to
pH.
AE3 has been suggested as a target for prevention of
diabetic vasculopathy.
See also
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Solute carrier family
References
Further reading
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Solute carrier family
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