Andy or Andrew O'Brien may refer to:
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Andy O'Brien (footballer)
Andrew James O'Brien (born 29 June 1979) is a former professional footballer who played as a centre-back. Born England, he won 26 caps for Republic of Ireland between 2001 and 2006 and was a member of Ireland's 2002 World Cup squad. He retired ...
(born 1979), Irish footballer
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Andy O'Brien (hurler) (born 1988), Irish hurler
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Andy O'Brien (journalist)
Andrew William O'Brien (February 11, 1910April 19, 1987) was a Canadian sports journalist. O'Brien spent 42 years covering sports for the ''Montreal Standard'', the ''Montreal Star'', and '' Weekend Magazine'', during which he covered 12 Olympic ...
(1910–1987), Canadian sports journalist
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Andy O'Brien (politician) (1915–2006), Irish Fine Gael senator
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Andrew O'Brien (politician) (fl. 1990s-2010s), US Department of State official
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Andrew O'Brien (rugby)
Andrew James O'Brien (1897–1969) was a New Zealand rugby footballer who represented New Zealand with the All Blacks and in New Zealand national rugby league team, rugby league.
Rugby union career
O'Brien began his career playing rugby union ...
(1897–1969), New Zealand rugby footballer
Fictional
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Andy O'Brien (''EastEnders''), a character in ''EastEnders''
{{human name disambiguation, name=Obrien, Andy