Andrea Marzi is a German-American

virologist Virology is the scientific study of biological viruses. It is a subfield of microbiology that focuses on their detection, structure, classification and evolution, their methods of infection and exploitation of host cells for reproduction, thei ...

. She is chief of the

immunobiology Immunology is a branch of medicineImmunology for Medical Students, Roderick Nairn, Matthew Helbert, Mosby, 2007 and biology that covers the medical study of immune systems in humans, animals, plants and sapient species. In such we can see there ...

and molecular virology unit at the

Rocky Mountain Laboratories Rocky Mountain Laboratories (RML) is part of the NIH Intramural Research Program and is located in Hamilton, Montana. Operated by the National Institute of Allergy and Infectious Diseases, RML conducts research on maximum containment pathogens suc ...

. Marzi investigates the

pathogenesis Pathogenesis is the process by which a disease or disorder develops. It can include factors which contribute not only to the onset of the disease or disorder, but also to its progression and maintenance. The word comes from Greek πάθος ''pat ...

filoviruses ''Filoviridae'' () is a family of single-stranded negative-sense RNA viruses in the order ''Mononegavirales''. Two members of the family that are commonly known are Ebola virus and Marburg virus. Both viruses, and some of their lesser known re ...

and vaccine development. She received the in recognition of her research.

Education

In 2007, Marzi received a Ph.D. in virology from the

University of Erlangen–Nuremberg University of Erlangen–Nuremberg (german: Friedrich-Alexander-Universität Erlangen-Nürnberg, FAU) is a Public University, public research university in the cities of Erlangen and Nuremberg in Bavaria, Germany. The name Friedrich–Alexander ...

where she studied the

glycoprotein Glycoproteins are proteins which contain oligosaccharide chains covalently attached to amino acid side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycos ...

-mediated entry of

Ebola virus ''Zaire ebolavirus'', more commonly known as Ebola virus (; EBOV), is one of six known species within the genus ''Ebolavirus''. Four of the six known ebolaviruses, including EBOV, cause a severe and often fatal hemorrhagic fever in humans and ot ...

(EBOV) and

HIV The human immunodeficiency viruses (HIV) are two species of ''Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune ...

. Her doctoral advisor was . Her dissertation was titled ''The role of cellular attachment factors for filovirus infection''. Later that year, Marzi moved to

Winnipeg Winnipeg () is the capital and largest city of the province of Manitoba in Canada. It is centred on the confluence of the Red and Assiniboine rivers, near the longitudinal centre of North America. , Winnipeg had a city population of 749,6 ...

to join Heinz Feldmann’s group at the

National Microbiology Laboratory The National Microbiology Laboratory (NML) is part of the Public Health Agency of Canada (PHAC), the agency of the Government of Canada that is responsible for public health, health emergency preparedness and response, and infectious and chronic ...

to work in the Biological Safety Level 4 (BSL4) on

and EBOV vaccines.

Career

In 2008, Marzi moved with Feldmann to the

and continued her BSL4 work on vaccine development for highly pathogenic viruses using primarily the

vesicular stomatitis virus ''Indiana vesiculovirus'', formerly ''Vesicular stomatitis Indiana virus'' (VSIV or VSV) is a virus in the family ''Rhabdoviridae''; the well-known ''Rabies lyssavirus'' belongs to the same family. VSIV can infect insects, cattle, horses and pigs ...

(VSV) platform. She also studied the pathogenesis of filoviruses and developed small animal models for these pathogens. Recently, she expanded the VSV vaccine platform to other emerging pathogens like

Zika virus ''Zika virus'' (ZIKV; pronounced or ) is a member of the virus family ''Flaviviridae''. It is spread by daytime-active ''Aedes'' mosquitoes, such as '' A. aegypti'' and '' A. albopictus''. Its name comes from the Ziika Forest of Uganda, whe ...

. In 2013, Marzi was promoted to staff scientist, and in 2017 to associate scientist. Marzi was selected as a

tenure-track Tenure is a category of academic appointment existing in some countries. A tenured post is an indefinite academic appointment that can be terminated only for cause or under extraordinary circumstances, such as financial exigency or program disco ...

investigator in the

National Institute of Allergy and Infectious Diseases The National Institute of Allergy and Infectious Diseases (NIAID, ) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS). NIAID's ...

Laboratory of Virology in 2019. She is chief of the

and

molecular virology Virology is the scientific study of biological viruses. It is a subfield of microbiology that focuses on their detection, structure, classification and evolution, their methods of infection and exploitation of host cells for reproduction, thei ...

unit.

Awards and honors

In 2019, the recognized Marzi with the for her research on filoviruses and vaccine development.

References

{{DEFAULTSORT:Marzi, Andrea Year of birth missing (living people) Place of birth missing (living people) National Institutes of Health people 21st-century American biologists 21st-century American women scientists American medical researchers Women medical researchers American virologists Women virologists Expatriate academics in the United States 21st-century German scientists German women biologists German virologists University of Erlangen-Nuremberg alumni German emigrants to the United States Living people 21st-century German women