Aminotransferase class-V is an evolutionary conserved

protein domain In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest. Each domain forms a compact folded three-dimensional structure. Many proteins consist of s ...

. This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-. Aminotransferases share certain mechanistic features with other pyridoxal- phosphate dependent enzymes, such as the covalent binding of the pyridoxal- phosphate group to a lysine residue. On the basis of sequence similarity, these various enzymes can be grouped into subfamilies. This family is called class-V.

Subfamilies

Phosphoserine aminotransferase Phosphoserine transaminase (, ''PSAT'', ''phosphoserine aminotransferase'', ''3-phosphoserine aminotransferase'', ''hydroxypyruvic phosphate-glutamic transaminase'', ''L-phosphoserine aminotransferase'', ''phosphohydroxypyruvate transaminase'', ''p ...

Cysteine desulfurase Cysteine (symbol Cys or C; ) is a semiessential proteinogenic amino acid with the formula . The thiol side chain in cysteine often participates in enzymatic reactions as a nucleophile. When present as a deprotonated catalytic residue, somet ...

* Cysteine desulphurase related, unknown function * Cysteine desulphurases, SufS * Cysteine desulphurase related * 2-aminoethylphosphonate—pyruvate transaminase

Human proteins containing this domain

AGXT Serine—pyruvate aminotransferase is an enzyme that in humans is encoded by the ''AGXT'' gene. This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxifica ...

;

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;

MOCOS Molybdenum cofactor sulfurase is an enzyme that in humans is encoded by the ''MOCOS'' gene. MOCOS sulfurates the molybdenum cofactor of xanthine dehydrogenase (XDH) and aldehyde oxidase Aldehyde oxidase (AO) is a metabolizing enzyme, locate ...

;

NFS1 Cysteine desulfurase, mitochondrial is an enzyme that in humans is encoded by the ''NFS1'' gene. Iron-sulfur clusters are required for the function of many cellular enzymes. The protein encoded by this gene supplies inorganic sulfur to these clu ...

;

PSAT1 Phosphoserine aminotransferase (PSA) also known as phosphohydroxythreonine aminotransferase (PSAT) is an enzyme that in humans is encoded by the ''PSAT1'' gene. The protein encoded by this gene is likely a phosphoserine aminotransferase, based o ...

; SCLY; TLH6;

References

{{InterPro content, IPR000192 Protein domains