4-amino-4-deoxychorismate lyase () is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different molecule ...
that participates in
folate biosynthesis by
catalyzing the production of
PABA by the following reaction
:4-amino-4-deoxychorismate
4-aminobenzoate + pyruvate
This enzyme belongs to the family of
lyase
In biochemistry, a lyase is an enzyme that catalyzes the breaking (an elimination reaction) of various chemical bond
A chemical bond is a lasting attraction between atoms or ions that enables the formation of molecules and crystals. The bon ...
s, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. This enzyme, encoded by the ''pabC'' gene in bacteria and plants, is also known as PabC or ADC lyase. The fungal enzyme has been designated ABZ2.
All known examples of 4-amino-4-deoxychorismate lyase bind PLP (
pyridoxal-5'-phosphate), a cofactor employed during catalysis.
References
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EC 4.1.3
{{4.1-enzyme-stub