Amidohydrolases (or amidases) are a type of
hydrolase
Hydrolase is a class of enzyme that commonly perform as biochemical catalysts that use water to break a chemical bond, which typically results in dividing a larger molecule into smaller molecules. Some common examples of hydrolase enzymes are este ...
that acts upon
amide
In organic chemistry, an amide, also known as an organic amide or a carboxamide, is a compound with the general formula , where R, R', and R″ represent organic groups or hydrogen atoms. The amide group is called a peptide bond when it i ...
bonds.
They are categorized under
EC number EC 3.5.1 and 3.5.2.
Examples include:
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Beta-lactamase
Beta-lactamases, (β-lactamases) are enzymes () produced by bacteria that provide multi-resistance to beta-lactam antibiotics such as penicillins, cephalosporins, cephamycins, monobactams and carbapenems ( ertapenem), although carbap ...
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Histone deacetylase
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Urease
Ureases (), functionally, belong to the superfamily of amidohydrolases and phosphotriesterases. Ureases are found in numerous bacteria, fungi, algae, plants, and some invertebrates, as well as in soils, as a soil enzyme. They are nickel-contai ...
The amidohydrolase superfamily is a large
protein family of more than 20,000 members with diverse chemistry and physiologic roles. Due to its complexity and size, the amidohydrolase superfamily is being used by the
Enzyme Function Initiative (EFI) for developing a large-scale strategy for functional assignment of unknown proteins.
See also
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EC 3.5.1
EC 3.5.2
Hydrolases
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