Amdoxovir is a pharmaceutical drug that has undergone research for the treatment of

HIV/AIDS Human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV), a retrovirus. Following initial infection an individual ...

. It acts as a

nucleoside reverse transcriptase inhibitor Reverse-transcriptase inhibitors (RTIs) are a class of antiretroviral drugs used to treat HIV infection or AIDS, and in some cases hepatitis B. RTIs inhibit activity of reverse transcriptase, a viral DNA polymerase that is required for replication ...

(NRTI). The drug was discovered by Raymond F. Schinazi (

Emory University Emory University is a private research university in Atlanta, Georgia. Founded in 1836 as "Emory College" by the Methodist Episcopal Church and named in honor of Methodist bishop John Emory, Emory is the second-oldest private institution of ...

) and C.K. Chu (

University of Georgia , mottoeng = "To teach, to serve, and to inquire into the nature of things.""To serve" was later added to the motto without changing the seal; the Latin motto directly translates as "To teach and to inquire into the nature of things." , establ ...

) and developed by RFS Pharma. Amdoxovir was in advanced

Phase II clinical trial The phases of clinical research are the stages in which scientists conduct experiments with a health intervention to obtain sufficient evidence for a process considered effective as a medical treatment. For drug development, the clinical phases ...

s around 2010. In 2013, a Phase II trial was terminated and another was withdrawn before it started. No further studies appear to have been done.

References

Nucleoside analog reverse transcriptase inhibitors Purines Dioxolanes Experimental antiviral drugs Hydroxymethyl compounds {{Antiinfective-drug-stub