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''Aloe vera'' () is a
succulent plant In botany, succulent plants, also known as succulents, are plants with parts that are thickened, fleshy, and engorged, usually to retain water in arid climates or soil conditions. The word ''succulent'' comes from the Latin word ''sucus'', meani ...
species In biology, a species is the basic unit of classification and a taxonomic rank of an organism, as well as a unit of biodiversity. A species is often defined as the largest group of organisms in which any two individuals of the appropriate s ...
of the
genus Genus ( plural genera ) is a taxonomic rank used in the biological classification of extant taxon, living and fossil organisms as well as Virus classification#ICTV classification, viruses. In the hierarchy of biological classification, genus com ...
''
Aloe ''Aloe'' (; also written ''Aloë'') is a genus containing over 650 species of flowering succulent plants.WFO (2022): Aloe L. Published on the Internet;http://www.worldfloraonline.org/taxon/wfo-4000001341. Accessed on: 06 Nov 2022 The most wid ...
''. It is widely distributed, and is considered an
invasive species An invasive species otherwise known as an alien is an introduced organism that becomes overpopulated and harms its new environment. Although most introduced species are neutral or beneficial with respect to other species, invasive species ad ...
in many world regions. An
evergreen In botany, an evergreen is a plant which has foliage that remains green and functional through more than one growing season. This also pertains to plants that retain their foliage only in warm climates, and contrasts with deciduous plants, which ...
perennial A perennial plant or simply perennial is a plant that lives more than two years. The term ('' per-'' + '' -ennial'', "through the years") is often used to differentiate a plant from shorter-lived annuals and biennials. The term is also wide ...
, it originates from the
Arabian Peninsula The Arabian Peninsula, (; ar, شِبْهُ الْجَزِيرَةِ الْعَرَبِيَّة, , "Arabian Peninsula" or , , "Island of the Arabs") or Arabia, is a peninsula of Western Asia, situated northeast of Africa on the Arabian Plate ...
, but grows wild in tropical, semi-tropical, and arid climates around the world. It is cultivated for commercial products, mainly as a
topical A topical medication is a medication that is applied to a particular place on or in the body. Most often topical medication means application to body surfaces such as the skin or mucous membranes to treat ailments via a large range of classes ...
treatment used over centuries. The species is attractive for decorative purposes, and succeeds indoors as a
potted plant Container gardening or pot gardening/farming is the practice of growing plants, including edible plants, exclusively in containers instead of planting them in the ground. A container in gardening is a small, enclosed and usually portable object ...
. It is used in many consumer products, including beverages, skin lotion, cosmetics, ointments or in the form of gel for minor burns and sunburns. There is little clinical evidence for the effectiveness or safety of ''Aloe vera'' extract as a
cosmetic Cosmetic may refer to: *Cosmetics, or make-up, substances to enhance the beauty of the human body, apart from simple cleaning *Cosmetic, an adjective describing beauty, aesthetics, or appearance, especially concerning the human body *Cosmetic, a t ...
or topical drug, and oral ingestion has risk of
toxicity Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism. Toxicity can refer to the effect on a whole organism, such as an animal, bacterium, or plant, as well as the effect on a subst ...
.


Etymology

The genus name ''
Aloe ''Aloe'' (; also written ''Aloë'') is a genus containing over 650 species of flowering succulent plants.WFO (2022): Aloe L. Published on the Internet;http://www.worldfloraonline.org/taxon/wfo-4000001341. Accessed on: 06 Nov 2022 The most wid ...
'' is derived from the Arabic word ''alloeh'', meaning "bitter and shiny substance" or from
Hebrew Hebrew (; ; ) is a Northwest Semitic language of the Afroasiatic language family. Historically, it is one of the spoken languages of the Israelites and their longest-surviving descendants, the Jews and Samaritans. It was largely preserved ...
''ahalim'', plural of ''ahal''. The
specific epithet In taxonomy, binomial nomenclature ("two-term naming system"), also called nomenclature ("two-name naming system") or binary nomenclature, is a formal system of naming species of living things by giving each a name composed of two parts, bot ...
''vera'' comes from ''verus'' meaning "true" in
Latin Latin (, or , ) is a classical language belonging to the Italic branch of the Indo-European languages. Latin was originally a dialect spoken in the lower Tiber area (then known as Latium) around present-day Rome, but through the power of the ...
.


Common names

Common names use ''aloe'' with a region of its distribution, such as ''Chinese aloe'', ''Cape aloe'' or ''
Barbados Barbados is an island country in the Lesser Antilles of the West Indies, in the Caribbean region of the Americas, and the most easterly of the Caribbean Islands. It occupies an area of and has a population of about 287,000 (2019 estimate). ...
aloe''.


Taxonomy

The species has several
synonyms A synonym is a word, morpheme, or phrase that means exactly or nearly the same as another word, morpheme, or phrase in a given language. For example, in the English language, the words ''begin'', ''start'', ''commence'', and ''initiate'' are all ...
: ''Aloe barbadensis'' Mill., ''Aloe indica'' Royle, ''Aloe perfoliata'' L. var. ''vera'' and ''Aloe vulgaris'' Lam. Some literature identifies the white-spotted form of ''Aloe vera'' as ''Aloe vera'' var. ''chinensis''; and the spotted form of ''Aloe vera'' may be
conspecific Biological specificity is the tendency of a characteristic such as a behavior or a biochemical variation to occur in a particular species. Biochemist Linus Pauling stated that "Biological specificity is the set of characteristics of living organ ...
with ''A. massawana''. The species was first described by
Carl Linnaeus Carl Linnaeus (; 23 May 1707 – 10 January 1778), also known after his ennoblement in 1761 as Carl von Linné Blunt (2004), p. 171. (), was a Swedish botanist, zoologist, taxonomist, and physician who formalised binomial nomenclature, the ...
in 1753 as ''Aloe perfoliata'' var. ''vera'', and was described again in 1768 by
Nicolaas Laurens Burman Nicolaas Laurens Burman (27 December 1734 – 11 September 1793) was a Dutch botanist. He was the son of Johannes Burman (1707–1780). He succeeded his father to the chair of botany at the Athenaeum Illustre of Amsterdam., and at the Hortus Bot ...
as ''Aloe vera'' in ''Flora Indica'' on 6 April and by
Philip Miller Philip Miller FRS (1691 – 18 December 1771) was an English botanist and gardener of Scottish descent. Miller was chief gardener at the Chelsea Physic Garden for nearly 50 years from 1722, and wrote the highly popular ''The Gardeners Dictio ...
as ''Aloe barbadensis'' some ten days after Burman in the ''Gardener's Dictionary''. Techniques based on DNA comparison suggest ''Aloe vera'' is relatively closely related to ''
Aloe perryi ''Aloe perryi'' (syn. ''Aloe forbesii'' Balf.f.; ''Aloe socotrina'') is a species of plant in the genus Aloe. It is endemic to the island of Socotra in Yemen, and is often known by its common name, Socotrine aloe.''Western Arabia and the Red Sea ...
'', a species endemic to Yemen. Similar techniques, using
chloroplast A chloroplast () is a type of membrane-bound organelle known as a plastid that conducts photosynthesis mostly in plant and algal cells. The photosynthetic pigment chlorophyll captures the energy from sunlight, converts it, and stores it in ...
DNA sequence comparison and ISSR profiling have also suggested it is closely related to ''
Aloe forbesii ''Aloe forbesii'' is a small stemless ''Aloe'' native to Socotra, Yemen Yemen (; ar, ٱلْيَمَن, al-Yaman), officially the Republic of Yemen,, ) is a country in Western Asia. It is situated on the southern end of the Arabian Peninsu ...
'', ''
Aloe inermis ''Aloe inermis'' is a small, stemless Aloe native to Yemen. See also *Succulent plant In botany, succulent plants, also known as succulents, are plants with parts that are thickened, fleshy, and engorged, usually to retain water in arid clima ...
'', '' Aloe scobinifolia'', '' Aloe sinkatana'', and ''
Aloe striata ''Aloe striata'', with the common name coral aloe, is a small, stemless South African Aloe species. Distribution This species occurs quite widely over the southern parts of the Cape Floristic Region, in the Eastern Cape Province and Western Cape ...
''. With the exception of the South African species ''A. striata'', these ''Aloe'' species are native to
Socotra Socotra or Soqotra (; ar, سُقُطْرَىٰ ; so, Suqadara) is an island of the Republic of Yemen in the Indian Ocean, under the ''de facto'' control of the UAE-backed Southern Transitional Council, a secessionist participant in Yemen’s ...
(Yemen), Somalia, and Sudan. The lack of obvious natural populations of the species has led some authors to suggest ''Aloe vera'' may be of
hybrid Hybrid may refer to: Science * Hybrid (biology), an offspring resulting from cross-breeding ** Hybrid grape, grape varieties produced by cross-breeding two ''Vitis'' species ** Hybridity, the property of a hybrid plant which is a union of two dif ...
origin.


Description

''Aloe vera'' is a stemless or very short-stemmed plant growing to tall, spreading by offsets.


Leaves

The leaves are thick and fleshy, green to grey-green, with some varieties showing white flecks on their upper and lower stem surfaces.Yates A. (2002) ''Yates Garden Guide''. Harper Collins Australia The margin of the leaf is
serrated Serration is a saw-like appearance or a row of sharp or tooth-like projections. A serrated cutting edge has many small points of contact with the material being cut. By having less contact area than a smooth blade or other edge, the applied pr ...
and has small white teeth. ''Aloe vera'' leaves contain
phytochemical Phytochemicals are chemical compounds produced by plants, generally to help them resist fungi, bacteria and plant virus infections, and also consumption by insects and other animals. The name comes . Some phytochemicals have been used as poisons ...
s under study for possible bioactivity, such as
lignan The lignans are a large group of low molecular weight polyphenols found in plants, particularly seeds, whole grains, and vegetables. The name derives from the Latin word for "wood". Lignans are precursors to phytoestrogens. They may play a role ...
s,
phytosterol Phytosterols are phytosteroids, similar to cholesterol, that serve as structural components of biological membranes of plants. They encompass plant sterols and stanols. More than 250 sterols and related compounds have been identified. Free phyto ...
s,
polyphenol Polyphenols () are a large family of naturally occurring organic compounds characterized by multiples of phenol units. They are abundant in plants and structurally diverse. Polyphenols include flavonoids, tannic acid, and ellagitannin, some of ...
s, acetylated
mannans Mannans are polymers containing the sugar mannose as a principal component. They are a type of polysaccharide comprise hemicellulose, a major source of biomass found in higher plants such as softwoods. These polymers also typically contain two ot ...
, polymannans,
anthraquinone Anthraquinone, also called anthracenedione or dioxoanthracene, is an aromatic organic compound with formula . Isomers include various quinone derivatives. The term anthraquinone however refers to the isomer, 9,10-anthraquinone (IUPAC: 9,10-dioxo ...
C-
glycoside In chemistry, a glycoside is a molecule in which a sugar is bound to another functional group via a glycosidic bond. Glycosides play numerous important roles in living organisms. Many plants store chemicals in the form of inactive glycosides. ...
s,
anthrone Anthrone is a tricyclic aromatic ketone. It is used for a common cellulose assay and in the colorimetric determination of carbohydrates. Derivatives of anthrone are used in pharmacy as laxative. They stimulate the motion of the colon and reduce w ...
s, and other anthraquinones, such as
emodin Emodin (6-methyl-1,3,8-trihydroxyanthraquinone) is a chemical compound, of the anthraquinone family, that can be isolated from rhubarb, buckthorn, and Japanese knotweed (''Reynoutria japonica'' syn. ''Polygonum cuspidatum''). Emodin is particular ...
and various
lectin Lectins are carbohydrate-binding proteins that are highly specific for sugar groups that are part of other molecules, so cause agglutination of particular cells or precipitation of glycoconjugates and polysaccharides. Lectins have a role in rec ...
s.


Flowers

The flowers are produced in summer on a spike up to tall, each flower being pendulous, with a yellow tubular corolla long. Random House Australia ' Like other ''Aloe'' species, ''Aloe vera'' forms
arbuscular mycorrhiza An arbuscular mycorrhiza (AM) (plural ''mycorrhizae'', a.k.a. ''endomycorrhiza'') is a type of mycorrhiza in which the symbiont fungus (''AM fungi'', or AMF) penetrates the cortical cells of the roots of a vascular plant forming arbuscules. (N ...
, a
symbiosis Symbiosis (from Greek , , "living together", from , , "together", and , bíōsis, "living") is any type of a close and long-term biological interaction between two different biological organisms, be it mutualistic, commensalistic, or parasit ...
that allows the plant better access to mineral nutrients in soil.


Distribution

''A. vera'' is considered to be native only to the south-east
Arabian Peninsula The Arabian Peninsula, (; ar, شِبْهُ الْجَزِيرَةِ الْعَرَبِيَّة, , "Arabian Peninsula" or , , "Island of the Arabs") or Arabia, is a peninsula of Western Asia, situated northeast of Africa on the Arabian Plate ...
in the
Al Hajar Mountains The Hajar Mountains ( ar, جِبَال ٱلْحَجَر, Jibāl al-Ḥajar, ''The Rocky Mountains'' or ''The Stone Mountains'') in northeastern Oman and also the eastern United Arab Emirates are the highest mountain range in the eastern Arabian ...
in north-eastern Oman. However, it has been widely cultivated around the world, and has become naturalized in North Africa, as well as Sudan and neighboring countries, along with the
Canary Islands The Canary Islands (; es, Canarias, ), also known informally as the Canaries, are a Spanish autonomous community and archipelago in the Atlantic Ocean, in Macaronesia. At their closest point to the African mainland, they are west of Morocc ...
,
Cape Verde , national_anthem = () , official_languages = Portuguese , national_languages = Cape Verdean Creole , capital = Praia , coordinates = , largest_city = capital , demonym ...
, and
Madeira Islands ) , anthem = ( en, "Anthem of the Autonomous Region of Madeira") , song_type = Regional anthem , image_map=EU-Portugal_with_Madeira_circled.svg , map_alt=Location of Madeira , map_caption=Location of Madeira , subdivision_type=Sovereign st ...
. It has also naturalized in the
Algarve The Algarve (, , ; from ) is the southernmost NUTS II region of continental Portugal. It has an area of with 467,495 permanent inhabitants and incorporates 16 municipalities ( ''concelhos'' or ''municípios'' in Portuguese). The region has it ...
region of Portugal, and in wild areas across southern Spain, especially in the
region of Murcia The Region of Murcia (, ; es, Región de Murcia ), is an Autonomous communities of Spain, autonomous community of Spain located in the southeastern part of the Iberian Peninsula, on the Mediterranean Sea, Mediterranean coast. The region is in ...
. The species was introduced to China and various parts of southern Europe in the 17th century. It is widely naturalized elsewhere, occurring in arid, temperate, and tropical regions of temperate continents. The current distribution may be the result of cultivation.


Cultivation

''Aloe vera'' has been widely grown as an ornamental plant. The species is popular with modern gardeners as a topical
medicinal plant Medicinal plants, also called medicinal herbs, have been discovered and used in traditional medicine practices since prehistoric times. Plants synthesize hundreds of chemical compounds for various functions, including Plant defense against her ...
and for its interesting flowers, form, and succulence. This succulence enables the species to survive in areas of low natural rainfall, making it ideal for rockeries and other low water-use gardens. The species is hardy in
zones Zone or The Zone may refer to: Places Climate and altitude zones * Death zone (originally the lethal zone), altitudes above a certain point where the amount of oxygen is insufficient to sustain human life for an extended time span * Frigid zone, ...
8–11, and is intolerant of heavy frost and snow. The species is relatively resistant to most insect pests, though
spider mites Spider mites are members of the Tetranychidae family, which includes about 1,200 species. They are part of the subclass Acari (mites). Spider mites generally live on the undersides of leaves of plants, where they may spin protective silk webs, a ...
,
mealy bugs Mealybugs are insects in the family (biology), family Pseudococcidae, unarmored scale insects found in moist, warm habitats. Many species are considered pest (animal), pests as they feed on plant juices of greenhouse plants, house plants and sub ...
,
scale insects Scale insects are small insects of the order Hemiptera, suborder Sternorrhyncha. Of dramatically variable appearance and extreme sexual dimorphism, they comprise the infraorder Coccomorpha which is considered a more convenient grouping than the ...
, and
aphid Aphids are small sap-sucking insects and members of the superfamily Aphidoidea. Common names include greenfly and blackfly, although individuals within a species can vary widely in color. The group includes the fluffy white woolly aphids. A t ...
species may cause a decline in plant health. This plant has gained the
Royal Horticultural Society The Royal Horticultural Society (RHS), founded in 1804 as the Horticultural Society of London, is the UK's leading gardening charity. The RHS promotes horticulture through its five gardens at Wisley (Surrey), Hyde Hall (Essex), Harlow Carr (Nort ...
's
Award of Garden Merit The Award of Garden Merit (AGM) is a long-established annual award for plants by the British Royal Horticultural Society (RHS). It is based on assessment of the plants' performance under UK growing conditions. History The Award of Garden Merit ...
. In pots, the species requires well-drained, sandy potting soil, and bright, sunny conditions. Aloe plants can turn red from sunburn under too much direct sun, though gradual acclimation may help. The use of a good-quality commercial propagation mix or packaged "cacti and succulent mix" is recommended, as they allow good drainage. Terra cotta pots are preferable as they are porous. Potted plants should be allowed to completely dry before rewatering. When potted, aloes can become crowded with "pups" growing from the sides of the "mother plant". Plants that have become crowded can be divided and repotted to allow room for further growth, or the pups can be left with the mother plant. During winter, ''Aloe vera'' may become dormant, during which little moisture is required. In areas that receive frost or snow, the species is best kept indoors or in heated glasshouses. Houseplants requiring similar care include
haworthia ''Haworthia'' is a large genus of small succulent plants endemic to Southern Africa (Mozambique, Namibia, Lesotho, Eswatini and South Africa). Like the aloes, they are members of the subfamily Asphodeloideae and they generally resemble mi ...
and
agave ''Agave'' (; ; ) is a genus of monocots native to the hot and arid regions of the Americas and the Caribbean, although some ''Agave'' species are also native to tropical areas of North America, such as Mexico. The genus is primarily known for ...
. There is large-scale agricultural production of ''Aloe vera'' in Australia, Cuba, the Dominican Republic, China, Mexico, India, Jamaica, Kenya, Tanzania, South Africa, Spain, and the United States, with much of the output going toward the cosmetics industry.


Uses

Two substances from ''Aloe vera'' – a clear
gel A gel is a semi-solid that can have properties ranging from soft and weak to hard and tough. Gels are defined as a substantially dilute cross-linked system, which exhibits no flow when in the steady-state, although the liquid phase may still di ...
and its yellow
latex Latex is an emulsion (stable dispersion) of polymer microparticles in water. Latexes are found in nature, but synthetic latexes are common as well. In nature, latex is found as a milky fluid found in 10% of all flowering plants (angiosperms ...
– are used to manufacture commercial products. Aloe gel typically is used to make
topical medication A topical medication is a medication that is applied to a particular place on or in the body. Most often topical medication means application to body surfaces such as the skin or mucous membranes to treat ailments via a large range of classes ...
s for skin conditions, such as burns, wounds, frostbite,
rash A rash is a change of the human skin which affects its color, appearance, or texture. A rash may be localized in one part of the body, or affect all the skin. Rashes may cause the skin to change color, itch, become warm, bumpy, chapped, dry, cr ...
es,
psoriasis Psoriasis is a long-lasting, noncontagious autoimmune disease characterized by raised areas of abnormal skin. These areas are red, pink, or purple, dry, itchy, and scaly. Psoriasis varies in severity from small, localized patches to complete ...
,
cold sores Herpes labialis, commonly known as cold sores or fever blisters, is a type of infection by the herpes simplex virus that affects primarily the lip. Symptoms typically include a burning pain followed by small blisters or sores. The first attack ...
, or dry skin. Aloe latex is used individually or manufactured as a product with other ingredients to be ingested for relief of
constipation Constipation is a bowel dysfunction that makes bowel movements infrequent or hard to pass. The stool is often hard and dry. Other symptoms may include abdominal pain, bloating, and feeling as if one has not completely passed the bowel movement ...
. Aloe latex may be obtained in a dried form called ''resin'' or as "aloe dried juice". There is conflicting evidence regarding whether ''Aloe vera'' is effective as a treatment for wounds or burns. There is some evidence that topical use of aloe products might relieve symptoms of certain skin disorders, such as
psoriasis Psoriasis is a long-lasting, noncontagious autoimmune disease characterized by raised areas of abnormal skin. These areas are red, pink, or purple, dry, itchy, and scaly. Psoriasis varies in severity from small, localized patches to complete ...
,
acne Acne, also known as ''acne vulgaris'', is a long-term Cutaneous condition, skin condition that occurs when Keratinocyte, dead skin cells and Sebum, oil from the skin clog hair follicles. Typical features of the condition include comedo, black ...
, or
rash A rash is a change of the human skin which affects its color, appearance, or texture. A rash may be localized in one part of the body, or affect all the skin. Rashes may cause the skin to change color, itch, become warm, bumpy, chapped, dry, cr ...
es, but topical application may cause an
allergic reaction Allergies, also known as allergic diseases, refer a number of conditions caused by the hypersensitivity of the immune system to typically harmless substances in the environment. These diseases include hay fever, food allergies, atopic derma ...
in some people. ''Aloe vera''
gel A gel is a semi-solid that can have properties ranging from soft and weak to hard and tough. Gels are defined as a substantially dilute cross-linked system, which exhibits no flow when in the steady-state, although the liquid phase may still di ...
is used commercially as an ingredient in
yogurt Yogurt (; , from tr, yoğurt, also spelled yoghurt, yogourt or yoghourt) is a food produced by bacterial Fermentation (food), fermentation of milk. The bacteria used to make yogurt are known as ''yogurt cultures''. Fermentation of sugars in t ...
s, beverages, and some desserts, but at high or prolonged doses, ingesting aloe latex or whole leaf extract can be toxic. Use of topical aloe vera in small amounts is likely to be safe.


Topical medication and potential side effects

''Aloe vera'' may be prepared as a
lotion Lotion is a low-viscosity topical preparation intended for application to the skin. By contrast, creams and gels have higher viscosity, typically due to lower water content. Lotions are applied to external skin with bare hands, a brush, a clean ...
,
gel A gel is a semi-solid that can have properties ranging from soft and weak to hard and tough. Gels are defined as a substantially dilute cross-linked system, which exhibits no flow when in the steady-state, although the liquid phase may still di ...
, soap or
cosmetics Cosmetics are constituted mixtures of chemical compounds derived from either natural sources, or synthetically created ones. Cosmetics have various purposes. Those designed for personal care and skin care can be used to cleanse or protect ...
product for use on skin as a topical medication. For people with
allergies Allergies, also known as allergic diseases, refer a number of conditions caused by the hypersensitivity of the immune system to typically harmless substances in the environment. These diseases include hay fever, food allergies, atopic derma ...
to ''Aloe vera'', skin reactions may include
contact dermatitis Contact dermatitis is a type of acute or chronic inflammation of the skin caused by exposure to chemical or physical agents. Symptoms of contact dermatitis can include itchy or dry skin, a red rash, bumps, blisters, or swelling. These rashes are ...
with mild redness and itching, difficulty with breathing, or swelling of the face, lips, tongue, or throat.


Dietary supplement

Aloin Aloin, also known as barbaloin, is a bitter, yellow-brown colored compound noted in the exudate of at least 68 ''Aloe'' species at levels from 0.1 to 6.6% of leaf dry weight (making between 3% and 35% of the total exudate), and in another 17 spec ...
, a compound found in the semi-liquid latex of some ''Aloe'' species, was the common ingredient in
over-the-counter Over-the-counter (OTC) drugs are medicines sold directly to a consumer without a requirement for a prescription from a healthcare professional, as opposed to prescription drugs, which may be supplied only to consumers possessing a valid prescr ...
(OTC)
laxative Laxatives, purgatives, or aperients are substances that loosen stools and increase bowel movements. They are used to treat and prevent constipation. Laxatives vary as to how they work and the side effects they may have. Certain stimulant, lubri ...
products in the United States until 2002 when the
Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respon ...
banned it because manufacturers failed to provide the necessary safety data. ''Aloe vera'' has potential toxicity, with
side effects In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequence ...
occurring at some dose levels both when ingested and when applied topically. Although toxicity may be less when aloin is removed by processing, ''Aloe vera'' ingested in high amounts may induce side effects, such as
abdominal pain Abdominal pain, also known as a stomach ache, is a symptom Signs and symptoms are the observed or detectable signs, and experienced symptoms of an illness, injury, or condition. A sign for example may be a higher or lower temperature than ...
,
diarrhea Diarrhea, also spelled diarrhoea, is the condition of having at least three loose, liquid, or watery bowel movements each day. It often lasts for a few days and can result in dehydration due to fluid loss. Signs of dehydration often begin wi ...
or
hepatitis Hepatitis is inflammation of the liver tissue. Some people or animals with hepatitis have no symptoms, whereas others develop yellow discoloration of the skin and whites of the eyes (jaundice), poor appetite, vomiting, tiredness, abdominal pa ...
. Chronic ingestion of aloe (dose of 1 gram per day) may cause adverse effects, including
hematuria Hematuria or haematuria is defined as the presence of blood or red blood cells in the urine. “Gross hematuria” occurs when urine appears red, brown, or tea-colored due to the presence of blood. Hematuria may also be subtle and only detectable w ...
, weight loss, and cardiac or kidney disorders. ''Aloe vera'' juice is marketed to support the health of the digestive system, but there is neither scientific evidence nor regulatory approval for this claim. The extracts and quantities typically used for such purposes are associated with toxicity in a dose-dependent way.


Traditional medicine

''Aloe vera'' is used in traditional medicine as a skin treatment. Early records of its use appear from the fourth millennium
BCE Common Era (CE) and Before the Common Era (BCE) are year notations for the Gregorian calendar (and its predecessor, the Julian calendar), the world's most widely used calendar era. Common Era and Before the Common Era are alternatives to the or ...
. It is also written of in the ''
Juliana Anicia Codex The Vienna Dioscurides or Vienna Dioscorides is an early 6th-century Byzantine Greek illuminated manuscript of an even earlier 1st century AD work, ''De materia medica'' (Περὶ ὕλης ἰατρικῆς : Perì hylēs iatrikēs in the origi ...
'' of 512 CE.Reynolds, Tom (Ed.) (2004) ''Aloes: The genus Aloe (Medicinal and Aromatic Plants - Industrial Profiles''. CRC Press.


Commodities

''Aloe vera'' is used on
facial tissue Facial tissue and paper handkerchief refers to a class of soft, absorbent, disposable papers that are suitable for use on the face. They are disposable alternatives for cloth handkerchiefs. The terms are commonly used to refer to the type of pap ...
s where it is promoted as a moisturizer and anti-irritant to reduce chafing of the nose. Cosmetic companies commonly add sap or other derivatives from ''Aloe vera'' to products such as makeup, tissues, moisturizers, soaps, sunscreens, incense, shaving cream, or shampoos. A review of academic literature notes that its inclusion in many hygiene products is due to its "moisturizing emollient effect".


Toxicity

Orally ingested non-decolorized aloe vera leaf extract was listed by the
California Office of Environmental Health Hazard Assessment The Office of Environmental Health Hazard Assessment, commonly referred to as OEHHA (pronounced oh-EEE-ha), is a specialized department within the cabinet-level California Environmental Protection Agency ( CalEPA) with responsibility for evaluatin ...
among "chemicals known to the state to cause cancer or reproductive toxicity", possibly resulting from the anthraquinones. Use of aloe vera on the skin is generally not associated with significant side effects. Oral ingestion of aloe vera is potentially toxic, and may cause
abdominal cramps Abdominal pain, also known as a stomach ache, is a symptom associated with both non-serious and serious medical issues. Common causes of pain in the abdomen include gastroenteritis and irritable bowel syndrome. About 15% of people have a more ...
and
diarrhea Diarrhea, also spelled diarrhoea, is the condition of having at least three loose, liquid, or watery bowel movements each day. It often lasts for a few days and can result in dehydration due to fluid loss. Signs of dehydration often begin wi ...
which in turn can decrease the absorption of drugs.


Interactions with prescribed drugs

Ingested aloe products may have adverse interactions with prescription drugs, such as those used to treat
blood clot A thrombus (plural thrombi), colloquially called a blood clot, is the final product of the blood coagulation step in hemostasis. There are two components to a thrombus: aggregated platelets and red blood cells that form a plug, and a mesh of c ...
s,
diabetes Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ap ...
,
heart disease Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels. CVD includes coronary artery diseases (CAD) such as angina and myocardial infarction (commonly known as a heart attack). Other CVDs include stroke, hea ...
and
potassium Potassium is the chemical element with the symbol K (from Neo-Latin ''kalium'') and atomic number19. Potassium is a silvery-white metal that is soft enough to be cut with a knife with little force. Potassium metal reacts rapidly with atmosphe ...
-lowering agents (such as
Digoxin Digoxin (better known as Digitalis), sold under the brand name Lanoxin among others, is a medication used to treat various heart conditions. Most frequently it is used for atrial fibrillation, atrial flutter, and heart failure. Digoxin is on ...
), and
diuretic A diuretic () is any substance that promotes diuresis, the increased production of urine. This includes forced diuresis. A diuretic tablet is sometimes colloquially called a water tablet. There are several categories of diuretics. All diuretics in ...
s, among others.


Gallery

File:Aloe vera leaf showing the gel (1).JPG, Leaf and inner gel File:Aloe vera gel.jpg, Gel used for
dessert Dessert is a course (food), course that concludes a meal. The course consists of sweet foods, such as confections, and possibly a beverage such as dessert wine and liqueur. In some parts of the world, such as much of Greece and West Africa, and ...
s File:Es Lidah Buaya.JPG, Es lidah buaya, an Indonesian ''Aloe vera'' iced drink File:Gelaloevera.JPG, Juice File:Cut Aloe Vera Leaf.jpg, Cut leaf File:Aloe vera cut leaf drawing1.jpg, Diagram of leaf: 1 Cuticle,   2 Chloroplast parenchym,   3 Inner tissue,   4 Vascular bundles File:Aloe Vera Buds.jpg, Buds File:Aloe Vera flower.jpg, Flower buds File:Aloe vera flower 2.jpg, Flowers File:AloeBluhendD2.JPG, Plants of different sizes File:A potted aloe vera plant.jpg, A potted plant File:Aloe plant bud.jpg,
Sucker Sucker may refer to: General use * Lollipop or sucker, a type of confection * Sucker (slang), a slang term for a very gullible person * Hard candy ** Cough drop ** Mint (candy) Biology * Sucker (botany), a term for a shoot that arises undergro ...


See also

*
Medicinal plants Medicinal plants, also called medicinal herbs, have been discovered and used in traditional medicine practices since prehistoric times. Plants synthesize hundreds of chemical compounds for various functions, including defense and protection ag ...
*
Succulent plants In botany, succulent plants, also known as succulents, are plants with parts that are thickened, fleshy, and engorged, usually to retain water in arid climates or soil conditions. The word ''succulent'' comes from the Latin word ''sucus'', meani ...


References


External links

* {{DEFAULTSORT:Aloe vera vera Drought-tolerant plants Flora of the Arabian Peninsula Garden plants of Africa