Allylglycine is a glycine derivative. It is an

inhibitor Inhibitor or inhibition may refer to: In biology * Enzyme inhibitor, a substance that binds to an enzyme and decreases the enzyme's activity * Reuptake inhibitor, a substance that increases neurotransmission by blocking the reuptake of a neurotra ...

of glutamate decarboxylase. Inhibition of glutamate decarboxylase blocks GABA

biosynthesis Biosynthesis is a multi-step, enzyme-catalyzed process where substrates are converted into more complex products in living organisms. In biosynthesis, simple compounds are modified, converted into other compounds, or joined to form macromolecules. ...

, leading to lower levels of the

neurotransmitter A neurotransmitter is a signaling molecule secreted by a neuron to affect another cell across a synapse. The cell receiving the signal, any main body part or target cell, may be another neuron, but could also be a gland or muscle cell. Neuro ...

. Allylglycine is known to induce

seizure An epileptic seizure, informally known as a seizure, is a period of symptoms due to abnormally excessive or synchronous neuronal activity in the brain. Outward effects vary from uncontrolled shaking movements involving much of the body with los ...

s in animals studies, presumably due to this GDC-inhibiting activity.

References

Alpha-Amino acids Convulsants Glutamate decarboxylase inhibitors Enzyme inhibitors Allyl compounds {{nervous-system-drug-stub

See also

References