Allene Oxide Cyclase on:
[Wikipedia]
[Google]
[Amazon]
In 
enzymology
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
, an allene-oxide cyclase () is an enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
that belongs to the family of isomerases, specifically a class of other intramolecular oxidoreductase
In biochemistry, an oxidoreductase is an enzyme that catalyzes the transfer of electrons from one molecule, the reductant, also called the electron donor, to another, the oxidant, also called the electron acceptor. This group of enzymes usually ut ...
s. The systematic name of this enzyme class is (9''Z'')-(13''S'')-12,13-epoxyoctadeca-9,11,15-trienoate isomerase (cyclizing).
The allene oxide In organic chemistry, an allene oxide is an epoxide of an allene. The parent allene oxide is CH2=C(O)CH2 (CAS RN 40079-14-9), a rare and reactive species of only theoretical interest. Typical allene oxides require steric protection for their isol ...
of linolenic acid
Linolenic acid is a type of naturally-occurring fatty acid. It can refer to either of two octadecatrienoic acids (i.e. with an 18-carbon chain and three double bonds, which are found in the '' cis'' configuration), or a mixture of the two. Lino ...
(i.e., (9''Z'')-(13''S'')-12,13-epoxyoctadeca-9,11,15-trienoate) is converted by allene oxide cyclase to jasmonic acid
Jasmonic acid (JA) is an organic compound found in several plants including jasmine. The molecule is a member of the jasmonate class of plant hormones. It is biosynthesized from linolenic acid by the octadecanoid pathway. It was first isolat ...
((15''Z'')-12-oxophyto-10,15-dienoate).
Structural studies
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes , , , , , and .References
* EC 5.3.99 Enzymes of known structure {{isomerase-stub