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Alka-Seltzer is an
effervescent Effervescence is the escape of gas from an aqueous solution and the foaming or fizzing that results from that release. The word effervescence is derived from the Latin verb ''fervere'' (to boil), preceded by the adverb ''ex''. It has the same li ...
antacid An antacid is a substance which neutralizes stomach acidity and is used to relieve heartburn, indigestion or an upset stomach. Some antacids have been used in the treatment of constipation and diarrhea. Marketed antacids contain salts of alumi ...
and pain reliever first marketed by the Dr. Miles Medicine Company of
Elkhart, Indiana Elkhart ( ) is a city in Elkhart County, Indiana, United States. The city is located east of South Bend, Indiana, east of Chicago, Illinois, and north of Indianapolis, Indiana. Elkhart has the larger population of the two principal cities of th ...
,
United States The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territorie ...
. Alka-Seltzer contains three active ingredients:
aspirin Aspirin, also known as acetylsalicylic acid (ASA), is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and/or inflammation, and as an antithrombotic. Specific inflammatory conditions which aspirin is used to treat inc ...
(acetylsalicylic acid) (ASA),
sodium bicarbonate Sodium bicarbonate (IUPAC name: sodium hydrogencarbonate), commonly known as baking soda or bicarbonate of soda, is a chemical compound with the formula NaHCO3. It is a salt composed of a sodium cation ( Na+) and a bicarbonate anion ( HCO3−) ...
, and
anhydrous A substance is anhydrous if it contains no water. Many processes in chemistry can be impeded by the presence of water; therefore, it is important that water-free reagents and techniques are used. In practice, however, it is very difficult to achie ...
citric acid Citric acid is an organic compound with the chemical formula HOC(CO2H)(CH2CO2H)2. It is a colorless weak organic acid. It occurs naturally in citrus fruits. In biochemistry, it is an intermediate in the citric acid cycle, which occurs in t ...
. The aspirin is a pain reliever and
anti-inflammatory Anti-inflammatory is the property of a substance or treatment that reduces inflammation or swelling. Anti-inflammatory drugs, also called anti-inflammatories, make up about half of analgesics. These drugs remedy pain by reducing inflammation as o ...
, the sodium bicarbonate is an antacid, and the citric acid reacts with the sodium bicarbonate and water to form
effervescence Effervescence is the escape of gas from an aqueous solution and the foaming or fizzing that results from that release. The word effervescence is derived from the Latin verb ''fervere'' (to boil), preceded by the adverb ''ex''. It has the same lin ...
. It was developed by head chemist Maurice Treneer. Alka-Seltzer is marketed for relief of minor aches, pains,
inflammation Inflammation (from la, wikt:en:inflammatio#Latin, inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or Irritation, irritants, and is a protective response involving im ...
,
fever Fever, also referred to as pyrexia, is defined as having a body temperature, temperature above the human body temperature, normal range due to an increase in the body's temperature Human body temperature#Fever, set point. There is not a single ...
,
headache Headache is the symptom of pain in the face, head, or neck. It can occur as a migraine, tension-type headache, or cluster headache. There is an increased risk of depression in those with severe headaches. Headaches can occur as a result ...
,
heartburn Heartburn, also known as pyrosis, cardialgia or acid indigestion, is a burning sensation in the central chest or upper central abdomen. Heartburn is usually due to regurgitation of gastric acid (gastric reflux) into the esophagus. It is the ma ...
, stomachache,
indigestion Indigestion, also known as dyspepsia or upset stomach, is a condition of impaired digestion. Symptoms may include upper abdominal fullness, heartburn, nausea, belching, or upper abdominal pain. People may also experience feeling full earlier t ...
,
acid reflux Gastroesophageal reflux disease (GERD) or gastro-oesophageal reflux disease (GORD) is one of the upper gastrointestinal chronic diseases where stomach content persistently and regularly flows up into the esophagus, resulting in symptoms and/ ...
and hangovers, while
neutralizing A neutralizing antibody (NAb) is an antibody that defends a cell from a pathogen or infectious particle by neutralizing any effect it has biologically. Neutralization renders the particle no longer infectious or pathogenic. Neutralizing antibod ...
excess
stomach acid Gastric acid, gastric juice, or stomach acid is a digestive fluid formed within the stomach lining. With a pH between 1 and 3, gastric acid plays a key role in digestion of proteins by activating digestive enzymes, which together break down the ...
. It was launched in 1931. Its sister product, Alka-Seltzer Plus, treats cold and flu symptoms. A wide variety of formulae, many using
acetaminophen Paracetamol, also known as acetaminophen, is a medication used to treat fever and mild to moderate pain. Common brand names include Tylenol and Panadol. At a standard dose, paracetamol only slightly decreases body temperature; it is inferior ...
(paracetamol) instead of aspirin, are available under the sister brand.


Product information

Alka-Seltzer is a combination of
sodium bicarbonate Sodium bicarbonate (IUPAC name: sodium hydrogencarbonate), commonly known as baking soda or bicarbonate of soda, is a chemical compound with the formula NaHCO3. It is a salt composed of a sodium cation ( Na+) and a bicarbonate anion ( HCO3−) ...
,
aspirin Aspirin, also known as acetylsalicylic acid (ASA), is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and/or inflammation, and as an antithrombotic. Specific inflammatory conditions which aspirin is used to treat inc ...
, and
anhydrous A substance is anhydrous if it contains no water. Many processes in chemistry can be impeded by the presence of water; therefore, it is important that water-free reagents and techniques are used. In practice, however, it is very difficult to achie ...
citric acid Citric acid is an organic compound with the chemical formula HOC(CO2H)(CH2CO2H)2. It is a colorless weak organic acid. It occurs naturally in citrus fruits. In biochemistry, it is an intermediate in the citric acid cycle, which occurs in t ...
, used for the relief of heartburn, acid indigestion, and stomach aches. Alka-Seltzer is sold in foil packets, each containing two tablets. Prior to 1984, it was also available stacked in glass tubes. It is available in many different flavors. It was once marketed as a cure-all; at one time, its ads even suggested taking it for "the blahs". Subsequent promotion has taken into consideration that aspirin is a drug that is not tolerated by everyone, and the product is no longer advertised in this fashion.


Chemistry of the effervescence

Though important to the overall effect of the medication, the aspirin (
acetylsalicylic acid Aspirin, also known as acetylsalicylic acid (ASA), is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and/or inflammation, and as an antithrombotic. Specific inflammatory conditions which aspirin is used to treat inc ...
) is not required to produce the
effervescent Effervescence is the escape of gas from an aqueous solution and the foaming or fizzing that results from that release. The word effervescence is derived from the Latin verb ''fervere'' (to boil), preceded by the adverb ''ex''. It has the same li ...
action of Alka-Seltzer; the effervescence is produced by the baking soda (sodium bicarbonate) and citric acid reacting to form sodium citrate and carbon dioxide gas.


Marketing

The product has been extensively advertised since its launch in the United States. It was originally marketed by Mikey Wiseman, a company scientist of Dr. Miles Medicine Company, who also helped direct its development. Print advertising was used immediately, and in 1932 the radio show ''Alka-Seltzer Comedy Star of Hollywood'' began, with
National Barn Dance ''National Barn Dance'', broadcast by WLS-AM in Chicago, Illinois starting in 1924, was one of the first American country music radio programs and a direct precursor of the ''Grand Ole Opry''. ''National Barn Dance'' also set the stage for other ...
following in 1933, along with many more. The radio sponsorships continued into the 1950s, with the ''
Alka-Seltzer Time ''Alka-Seltzer Time'' (aka ''The Alka-Seltzer Show'') was a 15-minute radio series broadcast weekdays on both CBS Radio and the Mutual Broadcasting System (not to be confused with an earlier ''Alka-Seltzer Time'' that was renamed ''Herb Shriner ...
'' show airing from 1949 to 1957. In 1951, the "Speedy" character was introduced. The character was conceived by creative director George Pal of the Wade Advertising agency and designed by illustrator
Wally Wood Wallace Allan Wood (June 17, 1927 – November 2, 1981) was an American comic book writer, artist and independent publisher, widely known for his work on EC Comics's titles such as ''Weird Science (comic), Weird Science'', ''Weird Fantasy'', an ...
. Originally named Sparky, the name was changed to Speedy by sales manager Perry L. Shupert to align with that year's promotional theme, "Speedy Relief." Speedy appeared in over 200 TV commercials between 1954 and 1964. His body was one Alka-Seltzer tablet, while he wore another as a hat.
Buster Keaton Joseph Frank "Buster" Keaton (October 4, 1895 – February 1, 1966) was an American actor, comedian, and filmmaker. He is best known for his silent film work, in which his trademark was physical comedy accompanied by a stoic, deadpan expression ...
appeared along with the animated Speedy Alka-Seltzer figure in a series of 1950s commercials based on the product slogan, "Relief is just a swallow away." Speedy Alka-Seltzer was voiced by
Dick Beals Richard Beals (March 16, 1927 – May 29, 2012) was an American actor, who performed many voices in his career, which spanned the period from the early 1950s into the 21st century. Beals voiced both male and female children. Perhaps his most reco ...
. Speedy was revived for a "Plop, plop, fizz, fizz" song spot in 1976. In his 1976 revival Beals proclaimed Alka-Seltzer's virtues and sang the "Plop, plop, fizz, fizz, oh what a relief it is" song in his iconic high, squeaky voice. In the early 1960s, a commercial showing two tablets dropping into a glass of water instead of the usual one caused sales to double. Alka-Seltzer TV ads from the 1960s and 1970s in the US were among the most popular of the 20th century, ranking number 13, according to ''Advertising Age''. To increase sales in a relatively flat business, Bayer revived several of the vintage spots. Paul Margulies (father of actress
Julianna Margulies Julianna Margulies (; born June 8, 1966) is an American actress. After several small television roles, Margulies achieved wide recognition for her starring role as Carol Hathaway on NBC's long-running medical drama series '' ER'' (1994–2009), ...
) created the famous "Plop, plop, fizz, fizz" ad campaign when he worked as a
Madison Avenue Madison Avenue is a north-south avenue in the borough of Manhattan in New York City, United States, that carries northbound one-way traffic. It runs from Madison Square (at 23rd Street) to meet the southbound Harlem River Drive at 142nd Stre ...
ad executive. The ubiquitous jingle was composed by Tom Dawes—a former member of
The Cyrkle The Cyrkle was an American rock band active in the early and mid-1960s. The group charted two Top 40 hits, "Red Rubber Ball" and " Turn-Down Day". Career The band was formed by guitarists and lead singers Don Dannemann and Tom Dawes (who also p ...
. The slogan was altered to "Plink, plink, fizz" in the United Kingdom. During the race for space in the early 1960s before the moon landing, there was a commercial with Speedy in a space suit and a jingle with the lyrics "On Man's first trip through space, I only hope that I'm aboard, securely strapped in place. They'll track our ship with radar and telescopes and soon, imagine seeing Speedy Alka-Seltzer on the moon!"
George Raft George Raft (born George Ranft; September 26, 1901 – November 24, 1980) was an American film actor and dancer identified with portrayals of gangsters in crime melodramas of the 1930s and 1940s. A stylish leading man in dozens of movies, Raft is ...
starred in the 1969 Alka-Seltzer commercial "The Unfinished Lunch". It consisted of Raft incarcerated in a prison lunchroom. He takes a bite of the prison food and recoils. Suddenly he bangs his cup on the steel table. It ripples throughout the room. He starts intoning "Alka-Seltzer, Alka-Seltzer..." Soon, the other hundreds of inmates do the same. (The commercial became so popular that several weeks later, Raft appeared as a guest on ''
The Tonight Show Starring Johnny Carson ''The Tonight Show Starring Johnny Carson'' was an American late-night talk show hosted by Johnny Carson on NBC, the third iteration of the ''Tonight Show'' franchise. The show debuted on October 1, 1962, and aired its final episode on May 22, ...
''. Raft told Carson that it took more than 7 hours to tape the 30-second commercial. Raft was enraged by the end of the day, thus making his inmate portrayal that much more convincing for the final editing. The film crew gave Raft his crumpled tin cup, which he showed to Carson and the audience. An animated mid-1960s commercial, animated by R. O. Blechman, shows a man and his own stomach sitting opposite each other in chairs, having an argument moderated by their therapist in a voiceover. The stomach (voiced by
Gene Wilder Jerome Silberman (June 11, 1933 – August 29, 2016), known professionally as Gene Wilder, was an American actor, comedian, writer and filmmaker. He is known mainly for his comedic roles, but also for his portrayal of Willy Wonka in ''Willy Won ...
) accuses the man of purposely trying to irritate it. The man accuses his stomach of complaining too much about the foods he likes. The therapist suggests Alka-Seltzer, and further suggests that the two must take care of each other. The closing words are of the stomach saying to the man: "Well, I'll try — if you will." Alka-Seltzer had a series of commercials during the mid-1960s that used a song called "
No Matter What Shape (Your Stomach's In) "No Matter What Shape (Your Stomach's In)" is an instrumental composition recorded in 1965 by The T-Bones and released as a single the same year. Composer The record itself lists Granville Sascha Burland as the composer, but ASCAP says the compo ...
". A different version was recorded by
The T-Bones The T-Bones were an American, Liberty Records recording group, existing from 1963 to 1966. The studio recordings of all of their albums but the last were done by American session musicians, The Wrecking Crew. They should not be confused wit ...
and was released as a single, which became a hit in 1966. The ads featured only the midsections (no faces) of people of all shapes and sizes. A clip of the ad can be seen briefly in the 1988 motion picture '' The In Crowd'', immediately before the movie's first live broadcast of the fictitious "Perry Parker's Dance Party." In an Alka-Seltzer commercial from 1969, an actor (played by
Jack Somack Jack Somack (September 1, 1918 – August 24, 1983) was an American chemical engineer, and actor. He is best remembered for his appearance in the Alka-Seltzer "spicy meatball" television commercial. Life and career Somack was born in Chicago ...
) in a commercial for the fictional product "Magdalini's Meatballs" has to eat a meatball and then say "Mamma mia, that's-a spicy meat-a ball-a!" in an ersatz Italian accent. Take after take is ruined by some comedic trial or another (comedian
Ronny Graham Ronny Graham (August 26, 1919 – July 4, 1999) was an American actor and theater director, composer, lyricist, and writer. Life and career Graham was born Ronald Montcrief Stringer in Philadelphia, Pennsylvania, the second of five children born ...
dropping the clapperboard). By the commercial's end, Jack has eaten so many meatballs that it's "Alka-Seltzer to the rescue." With his stomach settled, Jack does a perfect take, except that the oven door falls off. The director (off-camera) sighs and says, "OK, let's break for lunch." A 1970 commercial shows a newlywed couple in the bedroom after the woman (played by
Alice Playten Alice Playten ('' née'' Plotkin; August 28, 1947 – June 25, 2011) was an American actress known for her high-pitched, child-like voice. Life and career Born in New York City, Playten began her career at age 11 in the Broadway musical ''Gyp ...
) has finished serving her husband (played by
Terry Kiser Terry Kiser (born August 1, 1939) is an American actor. Besides portraying the deceased title character of the comedy ''Weekend at Bernie's'' and its sequel, ''Weekend at Bernie's II'', he has more than 140 acting credits to his name, with a car ...
) a giant dumpling; the implication is that her cooking skills are severely lacking, despite her husband's lament, "I can't believe I ate that whole thing!", the commercial's
catchphrase A catchphrase (alternatively spelled catch phrase) is a phrase or expression recognized by its repeated utterance. Such phrases often originate in popular culture and in the arts, and typically spread through word of mouth and a variety of mass ...
. She lies on the bed in delusional triumph. She offers her beleaguered husband a heart-shaped meatloaf; he disappears to take some Alka-Seltzer. When she hears the fizzy noise coming from the bathroom, he quickly covers the glass of dissolving Alka-Seltzer as she wonders aloud if it is raining. Just when he has recovered his well-being, he hears her misreading recipes for dinner the next night: "Marshmallowed meatballs," "medium salad snails," and "pouched (actually poached) oysters". He returns to the bathroom for more Alka-Seltzer. The catchphrase, Howie Cohen told the ''
Los Angeles Times The ''Los Angeles Times'' (abbreviated as ''LA Times'') is a daily newspaper that started publishing in Los Angeles in 1881. Based in the LA-adjacent suburb of El Segundo since 2018, it is the sixth-largest newspaper by circulation in the Un ...
'', was inspired when he ate too much of the food at a
London London is the capital and largest city of England and the United Kingdom, with a population of just under 9 million. It stands on the River Thames in south-east England at the head of a estuary down to the North Sea, and has been a majo ...
commercial shoot because "I am a nice Jewish kid from the Bronx, so I ate everything," and when he told his wife "I can't believe I ate the whole thing", she said, "There's your next Alka-Seltzer commercial." A 1971 commercial featured another catch-phrase from Cohen (along with Bob Pasqualina), "Try it, you'll like it!" It was remade with
Kathy Griffin Kathleen Mary Griffin (born November 4, 1960) is an American comedian and actress who has starred in television comedy specials and has released comedy albums. In 2007 and 2008, Griffin won Primetime Emmy Awards for her reality show '' Kathy ...
in 2006. In 1972, an actor (Milt Moss) spent the commercial moaning, "I can't believe I ate that who-o-o-o-o-ole thing," while his wife (Lynn Whinic) made sarcastic comments and finally advised him to take some Alka-Seltzer. In 2005, this ad was also remade, featuring
Peter Boyle Peter Lawrence Boyle (October 18, 1935 – December 12, 2006) was an American actor. Known as a character actor, he played Frank Barone on the CBS sitcom ''Everybody Loves Raymond'' and the comical monster in Mel Brooks' film spoof ''Young Fra ...
and
Doris Roberts Doris May Roberts ( Green; November 4, 1925 – April 17, 2016) was an American actress whose career spanned seven decades of television and film. She received five Emmy Awards and a Screen Actors Guild award during her acting career, which bega ...
from the 1996–2005 TV sitcom ''
Everybody Loves Raymond ''Everybody Loves Raymond'' is an American sitcom television series created by Philip Rosenthal that aired on CBS from September 13, 1996, to May 16, 2005, with a total of 210 episodes spanning nine seasons. It was produced by Where's Lunch and ...
''. Sammy Davis, Jr. recorded two versions of the "Plop Plop Fizz Fizz" jingle in 1978, one of which (the "big band" version) was featured on a television commercial. Both the big band and rock versions had additional lyrics (with at least one verse unique to each song) written by Tom Dawes, former lead singer of
The Cyrkle The Cyrkle was an American rock band active in the early and mid-1960s. The group charted two Top 40 hits, "Red Rubber Ball" and " Turn-Down Day". Career The band was formed by guitarists and lead singers Don Dannemann and Tom Dawes (who also p ...
who wrote the original jingle. In 2009, the brand was featured in television commercials supporting the
United States Ski Team The U.S. Ski Team, operating under the auspices of U.S. Ski & Snowboard, develops and supports men's and women's athletes in the sports of alpine skiing, freestyle skiing, cross-country, ski jumping, and Nordic combined. Since 1974 the team and a ...
that included alpine skier
Lindsey Vonn Lindsey Caroline Vonn ( ; born October 18, 1984) is an American former World Cup alpine ski racer on the US Ski Team. She won four World Cup overall championships — second only amongst female skiers to Annemarie Moser-Pröll — with three ...
and Nordic combined skier
Bill Demong William Demong (born March 29, 1980 in Vermontville, New York) is an American former Nordic combined skier and Olympic gold medalist. Demong is a five-time Olympian, having competed in Nagano, Salt Lake City, Torino, Vancouver and Sochi. Career ...
. Miniature figures of the Speedy mascot were shown with each. Alka-Seltzer products are sold in nighttime and daytime, or non drowsy, formulas. The non-drowsy claims have recently been questioned. In December 2010, Alka-Seltzer began a series of new commercials featuring Speedy, using a CGI character, created by Animation Director David Hulin, to recreate the stop-motion puppetry of the 1950s and 1960s, with Speedy voiced by
Debi Derryberry Debi Derryberry is an American voice actress who has provided voices for a number of animations and video games. Biography Derryberry was born in Indio, California to a family of Hungarian Jewish descent. Her grandparents were Holocaust surviv ...
.


See also

*
Carbonated water Carbonated water (also known as soda water, sparkling water, fizzy water, club soda, water with gas, in many places as mineral water, or especially in the United States as seltzer or seltzer water) is water containing dissolved carbon dioxide gas, ...
* Brioschi


References


External links

* {{authority control Products introduced in 1931 Aspirin Bayer brands Drugs acting on the gastrointestinal system and metabolism Clio Award winners Antacids