Alice Motion
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Alice Elizabeth Motion (born Alice Williamson, 28 October 1984) is a British
chemist A chemist (from Greek ''chēm(ía)'' alchemy; replacing ''chymist'' from Medieval Latin ''alchemist'') is a scientist trained in the study of chemistry. Chemists study the composition of matter and its properties. Chemists carefully describe t ...
,
science communicator Science communication is the practice of informing, educating, raising awareness of science-related topics, and increasing the sense of wonder about scientific discoveries and arguments. Science communicators and audiences are ambiguously def ...
, and associate professor at the School of Chemistry, University of Sydney. She is the founder of the Breaking Good project which encourages high school and undergraduate students to take part in research that can benefit human health. In 2018, the Breaking Good project was a finalist on the
Google.org Google.org, founded in October 2005, is the charitable arm of Google, a multinational technology company. The organization has committed roughly US$100 million in investments and grants to nonprofits annually. The organization is noted for se ...
Impact Challenge.


Education

Motion received her MChem from the
University of Leeds , mottoeng = And knowledge will be increased , established = 1831 – Leeds School of Medicine1874 – Yorkshire College of Science1884 - Yorkshire College1887 – affiliated to the federal Victoria University1904 – University of Leeds , ...
in 2007 where she worked with
Philip Kocienski Philip Joseph Kocienski (born 23 December 1946) is a British organic chemist. He is an Emeritus Professor at the University of Leeds. Research Kocienski has made contributions to the design and development of new organometallic reagents in ...
on the synthesis of an N-acetylcolchinol-combretastatin hybrid. She moved to the
University of Cambridge The University of Cambridge is a public collegiate research university in Cambridge, England. Founded in 1209 and granted a royal charter by Henry III in 1231, Cambridge is the world's third oldest surviving university and one of its most pr ...
where she obtained her PhD in 2012 while working with Matthew J. Gaunt on strategies for asymmetric
aryl In organic chemistry, an aryl is any functional group or substituent derived from an aromaticity, aromatic ring, usually an aromatic hydrocarbon, such as phenyl and naphthyl. "Aryl" is used for the sake of abbreviation or generalization, and "Ar ...
ation.


Career

In 2012, Motion moved to the
University of Sydney The University of Sydney (USYD), also known as Sydney University, or informally Sydney Uni, is a public research university located in Sydney, Australia. Founded in 1850, it is the oldest university in Australia and is one of the country's ...
in Australia to work with Matthew H. Todd on the Open Source Malaria project as Postdoctoral Research Fellow. In 2014, she became a Postdoctoral Teaching Fellow at the same institution until her promotion to Lecturer in Chemical Education and Outreach at the same institution in 2017.
Pyrimethamine Pyrimethamine, sold under the brand name Daraprim among others, is a medication used with leucovorin (leucovorin is used to decrease side effects of pyrimethamine; it does not have intrinsic anti-parasitic activity) to treat the parasitic dise ...
is a
pharmaceutical medicine Pharmaceutical medicine is a medical discipline concerned with the discovery, evaluation, registration, monitoring and clinical aspects of pharmaceutical development. All medical specialties overlap to some extent, and likewise the boundaries of pha ...
used in combination with
leucovorin Folinic acid, also known as leucovorin, is a medication used to decrease the toxic effects of methotrexate and pyrimethamine. It is also used in combination with 5-fluorouracil to treat colorectal cancer and pancreatic cancer, may be used to tr ...
to treat
toxoplasmosis Toxoplasmosis is a parasitic disease caused by '' Toxoplasma gondii'', an apicomplexan. Infections with toxoplasmosis are associated with a variety of neuropsychiatric and behavioral conditions. Occasionally, people may have a few weeks or mont ...
and cystoisosporiasis and in combination with dapsone to prevent ''Pneumocystis jiroveci'' pneumonia in
HIV/AIDS Human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV), a retrovirus. Following initial infection an individual ...
patients. In 2015,
Turing Pharmaceuticals Vyera Pharmaceuticals (formerly Turing Pharmaceuticals) is a pharmaceutical company incorporated in Zug, Switzerland, with offices in New York City. The company started to do business in the US as Vyera Pharmaceuticals in September 2017. The co ...
drastically increased the price of pyrimethamine, which it markets as Daraprim, from about US$13.50 to $750 per tablet. In response, Motion, along with her academic advisor, Matthew H. Todd, and the Open Source Malaria team led a small team of high school students from Sydney Grammar School to synthesise the drug. The team produced 3.7 grams of pyrimethamine for under US$20, which would be worth between $US35,000 and $US110,000 in the United States according to
Turing Pharmaceuticals Vyera Pharmaceuticals (formerly Turing Pharmaceuticals) is a pharmaceutical company incorporated in Zug, Switzerland, with offices in New York City. The company started to do business in the US as Vyera Pharmaceuticals in September 2017. The co ...
's pricing. This received significant media attention and was featured in ''
The Guardian ''The Guardian'' is a British daily newspaper. It was founded in 1821 as ''The Manchester Guardian'', and changed its name in 1959. Along with its sister papers ''The Observer'' and ''The Guardian Weekly'', ''The Guardian'' is part of the Gu ...
'' and ''
Time Time is the continued sequence of existence and events that occurs in an apparently irreversible succession from the past, through the present, into the future. It is a component quantity of various measurements used to sequence events, ...
'' magazine, and on ABC News (Australia), the
BBC #REDIRECT BBC #REDIRECT BBC Here i going to introduce about the best teacher of my life b BALAJI sir. He is the precious gift that I got befor 2yrs . How has helped and thought all the concept and made my success in the 10th board exam. ...
...
, and
CNN CNN (Cable News Network) is a multinational cable news channel headquartered in Atlanta, Georgia, U.S. Founded in 1980 by American media proprietor Ted Turner and Reese Schonfeld as a 24-hour cable news channel, and presently owned by ...
. Motion, like her former research advisor, is a proponent of open science. She believes that open science and
research Research is " creative and systematic work undertaken to increase the stock of knowledge". It involves the collection, organization and analysis of evidence to increase understanding of a topic, characterized by a particular attentiveness ...
provides transparency of data and results that prevent unnecessary duplication. In December 2022 Motion was appointed interim director of Sydney Nano.


Honours and awards

*2015 –
ABC ABC are the first three letters of the Latin script known as the alphabet. ABC or abc may also refer to: Arts, entertainment, and media Broadcasting * American Broadcasting Company, a commercial U.S. TV broadcaster ** Disney–ABC Television ...
RN and
UNSW The University of New South Wales (UNSW), also known as UNSW Sydney, is a public research university based in Sydney, New South Wales, Australia. It is one of the founding members of Group of Eight, a coalition of Australian research-intensive ...
Top 5 Under 40 *2017 and 2018 – RACI Nyholm Lectureship: "Mother Nature's Molecules – the good, the bad and the ugly" *2020 – Celestino
Eureka Prize The Eureka Prizes are awarded annually by the Australian Museum, Sydney, to recognise individuals and organizations who have contributed to science and the understanding of science in Australia. They were founded in 1990 following a suggestion ...
for Promoting Understanding of Science


See also

* Open access * Open collaboration *
Open innovation Open innovation is a term used to promote an information age mindset toward innovation that runs counter to the secrecy and silo mentality of traditional corporate research labs. The benefits and driving forces behind increased openness have bee ...
*
Open science data Open scientific data or open research data is a type of open data focused on publishing observations and results of scientific activities available for anyone to analyze and reuse. A major purpose of the drive for open data is to allow the verificat ...
*
Open research Open research is research that is openly accessible and modifiable by others. The central theme of open research is to make clear accounts of research methods freely available via the internet, along with any data or results extracted or derived ...
*
Open-source model Open source is source code that is made freely available for possible modification and redistribution. Products include permission to use the source code, design documents, or content of the product. The open-source model is a decentralized sof ...


References


External links

* * *
Breaking GoodOpen Source MalariaOpen Source Malaria
on
GitHub GitHub, Inc. () is an Internet hosting service for software development and version control using Git. It provides the distributed version control of Git plus access control, bug tracking, software feature requests, task management, continu ...
{{DEFAULTSORT:Motion, Alice English chemists Women chemists Organic chemists Living people University of Sydney faculty 1984 births Science communicators