Alexander Kekulé
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Alexander S. Kekulé (born November 7, 1958 in
Munich Munich ( ; german: München ; bar, Minga ) is the capital and most populous city of the States of Germany, German state of Bavaria. With a population of 1,558,395 inhabitants as of 31 July 2020, it is the List of cities in Germany by popu ...
) is a German
physician A physician (American English), medical practitioner (Commonwealth English), medical doctor, or simply doctor, is a health professional who practices medicine, which is concerned with promoting, maintaining or restoring health through th ...
and
biochemist Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and Cell (biology), cell parts. The word "biochemist" is a portmanteau of ...
. Since 1999 he has held the chair for
Medical Microbiology Medical microbiology, the large subset of microbiology that is applied to medicine, is a branch of medical science concerned with the prevention, diagnosis and treatment of infectious diseases. In addition, this field of science studies various ...
and
Virology Virology is the Scientific method, scientific study of biological viruses. It is a subfield of microbiology that focuses on their detection, structure, classification and evolution, their methods of infection and exploitation of host (biology), ...
of the
Martin Luther University of Halle-Wittenberg Martin Luther University of Halle-Wittenberg (german: Martin-Luther-Universität Halle-Wittenberg), also referred to as MLU, is a public, research-oriented university in the cities of Halle and Wittenberg and the largest and oldest university i ...
and Director of the Institute for Medical Microbiology of the ''Universitätsklinikum Halle'' (University Hospital Halle).


Life

Kekulé is the son of the author Dagmar Kekulé. He attended the
Waldorf School Waldorf education, also known as Steiner education, is based on the educational philosophy of Rudolf Steiner, the founder of anthroposophy. Its educational style is holistic, intended to develop pupils' intellectual, artistic, and practical skil ...
and the ''Rupprecht-Gymnasium'' in Munich, where he received his
Abitur ''Abitur'' (), often shortened colloquially to ''Abi'', is a qualification granted at the end of secondary education in Germany. It is conferred on students who pass their final exams at the end of ISCED 3, usually after twelve or thirteen year ...
in 1979. He studied philosophy,
biochemistry Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and ...
and
human medicine Medicine is the science and practice of caring for a patient, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care practice ...
at the
Freie Universität Berlin The Free University of Berlin (, often abbreviated as FU Berlin or simply FU) is a public research university in Berlin, Germany. It is consistently ranked among Germany's best universities, with particular strengths in political science and t ...
and at the
Ludwig-Maximilians-Universität München The Ludwig Maximilian University of Munich (simply University of Munich or LMU; german: Ludwig-Maximilians-Universität München) is a public research university in Munich, Germany. It is Germany's sixth-oldest university in continuous operatio ...
until 1987. 1988 he worked as an associate for the management consultancy
McKinsey & Company McKinsey & Company is a global management consulting firm founded in 1926 by University of Chicago professor James O. McKinsey, that offers professional services to corporations, governments, and other organizations. McKinsey is the oldest and ...
in New York City (USA). From 1988 to 1993 he conducted research with Peter Hans Hofschneider at the
Max Planck Institute for Biochemistry The Max Planck Institute of Biochemistry (MPIB) is a research institute of the Max Planck Society located in Martinsried, a suburb of Munich. The institute was founded in 1973 by the merger of three formerly independent institutes: the Max Planck ...
in
Martinsried Martinsried is one of Munich's two science suburbs. It is a section of Planegg municipality in the district of Munich in Bavaria, Germany. Martinsried is best known as the location of the Max Planck Institute of Biochemistry, the Max Planck Inst ...
(
Bavaria Bavaria ( ; ), officially the Free State of Bavaria (german: Freistaat Bayern, link=no ), is a state in the south-east of Germany. With an area of , Bavaria is the largest German state by land area, comprising roughly a fifth of the total lan ...
). He received 1990 his PhD in biochemistry from the Free University of Berlin and in 1992 in medicine at the Ludwig Maximilians University in Munich. In 1993 he got his
habilitation Habilitation is the highest university degree, or the procedure by which it is achieved, in many European countries. The candidate fulfills a university's set criteria of excellence in research, teaching and further education, usually including a ...
degree in Medical Microbiology / Virology at the
Technical University of Munich The Technical University of Munich (TUM or TU Munich; german: Technische Universität München) is a public research university in Munich, Germany. It specializes in engineering, technology, medicine, and applied and natural sciences. Establis ...
. From 1993 to 1994 he spent one year as an assistant in internal medicine in the hospital of Barmherzigen Brüder in Munich. From 1994 to 1996 he worked at the ''Max von Pettenkofer-Institut'' at the Ludwig Maximilians University in Munich. Kekulé is Specialist in microbiology, virology and infection epidemiology and specialist in
Laboratory medicine A medical laboratory or clinical laboratory is a laboratory where tests are conducted out on clinical specimens to obtain information about the health of a patient to aid in diagnosis, treatment, and prevention of disease. Clinical Medical labor ...
. From 1997 to 1998 he was deputy head of the Institute for Virology at Eberhard-Karls-Universität Tübingen. In 1999 he accepted a professorship in medical microbiology and virology at the
Martin Luther University of Halle-Wittenberg Martin Luther University of Halle-Wittenberg (german: Martin-Luther-Universität Halle-Wittenberg), also referred to as MLU, is a public, research-oriented university in the cities of Halle and Wittenberg and the largest and oldest university i ...
. He was supespended because of falling short of this teaching load by Martin Luther University of Halle-Wittenberg shortly before Christmas in 2021. Kekulé is married, has five children and lives in Munich. In 1968 Kekulé had the leading role in the film " Bübchen" by
Roland Klick Roland Klick (born 1934) is a German film director and screenwriter. Biography Klick was born in Hof, Bavaria and grew up in Nennslingen after the war. Klick studied theater and German in Munich, worked as a cameraman on a film by Rolf Schünz ...
as a child actor under the actor name "Sascha Urchs".


Research areas

Kekulé's research focuses on
infectious disease An infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmissible disease or communicable dise ...
, biological
civil protection Civil defense ( en, region=gb, civil defence) or civil protection is an effort to protect the citizens of a state (generally non-combatants) from man-made and natural disasters. It uses the principles of emergency operations: prevention, miti ...
and
bioethics Bioethics is both a field of study and professional practice, interested in ethical issues related to health (primarily focused on the human, but also increasingly includes animal ethics), including those emerging from advances in biology, med ...
. In 1992, in search of the molecular causes of
liver cancer Liver cancer (also known as hepatic cancer, primary hepatic cancer, or primary hepatic malignancy) is cancer that starts in the liver. Liver cancer can be primary (starts in liver) or secondary (meaning cancer which has spread from elsewhere to th ...
, he and his research group were able to show that the X gene of the
hepatitis B virus ''Hepatitis B virus'' (HBV) is a partially double-stranded DNA virus, a species of the genus ''Orthohepadnavirus'' and a member of the ''Hepadnaviridae'' family of viruses. This virus causes the disease hepatitis B. Disease Despite there bein ...
activates a signaling cascade in the liver cell that is also responsible for the development of cancer Chemicals is responsible. Furthermore, with his working group he discovered the preS / S transactivator, a novel
regulator gene A regulator gene, regulator, or regulatory gene is a gene involved in controlling the expression of one or more other genes. Regulatory sequences, which encode regulatory genes, are often at the five prime end (5') to the start site of transcript ...
of hepatitis -B virus. Another focus of his work is the
influenza Influenza, commonly known as "the flu", is an infectious disease caused by influenza viruses. Symptoms range from mild to severe and often include fever, runny nose, sore throat, muscle pain, headache, coughing, and fatigue. These symptoms ...
pandemic A pandemic () is an epidemic of an infectious disease that has spread across a large region, for instance multiple continents or worldwide, affecting a substantial number of individuals. A widespread endemic (epidemiology), endemic disease wi ...
.


Honors and awards

Kekulé was awarded the
Hans Popper Hans Popper (24 November 1903 – 6 May 1988) was an Austrian-born Pathology, pathologist, Hepatology, hepatologist and teacher. Together with Dame Sheila Sherlock, he is widely regarded as the founding father of hepatology. He is the namesake of t ...
Award for Basic Research of the International Association for the Study of the Liver (1992) and the Karl Heinrich Bauer Memorial Prize for Cancer Research (1990) for his work in the field of cancer production by viruses. He also received the Doctoral Dissertation Prize of the German Society for Hygiene and Microbiology. (1991), the prize awarded by the Verband der Chemischen Industrie (1991) and the Journalism Prize of
SmithKline Beecham GSK plc, formerly GlaxoSmithKline plc, is a British multinational pharmaceutical and biotechnology company with global headquarters in London, England. Established in 2000 by a merger of Glaxo Wellcome and SmithKline Beecham. GSK is the tent ...
Foundation (1997). He was a scholarship holder of the German National Academic Foundation as well as Bavarian state winner of the competition Jugend forscht, at that time still under the name Alexander Urchs. Kekulé was a member of the Schutzkommission beim Bundesministerium des Innern and has been a member of the Arzneimittelkommission der deutschen Ärzteschaft as well as the selection committee of the Studienstiftung des deutschen Volkes. From 1990 to 2004 he was a member of the commission ''Teaching and Further Education'' of the Society for Virology.


Journalistic activity

Besides his scientific work, Kekulé publishes on social and ethical aspects of the natural sciences. His articles have appeared in the weekly newspaper ''
Die Zeit ''Die Zeit'' (, "The Time") is a German national weekly newspaper published in Hamburg in Germany. The newspaper is generally considered to be among the German newspapers of record and is known for its long and extensive articles. History The ...
'', the magazine ''
Der Spiegel ''Der Spiegel'' (, lit. ''"The Mirror"'') is a German weekly news magazine published in Hamburg. With a weekly circulation of 695,100 copies, it was the largest such publication in Europe in 2011. It was founded in 1947 by John Seymour Chaloner ...
'', the daily newspaper ''
Neue Zürcher Zeitung The ''Neue Zürcher Zeitung'' (''NZZ''; "New Journal of Zürich") is a Swiss, German-language daily newspaper, published by NZZ Mediengruppe in Zürich. The paper was founded in 1780. It was described as having a reputation as a high-quality ne ...
'' and the weekly newspaper '' Jüdische Allgemeine''. Since 1999, he has been writing the column "Was Wissen schafft" (What knowledge creates) in the daily newspaper ''
Der Tagesspiegel ''Der Tagesspiegel'' (meaning ''The Daily Mirror'') is a German daily newspaper. It has regional correspondent offices in Washington D.C. and Potsdam. It is the only major newspaper in the capital to have increased its circulation, now 148,000, s ...
''. In 2001 Kekulé pleaded for the establishment of a global fund for the fight against AIDS in the
Third World The term "Third World" arose during the Cold War to define countries that remained non-aligned with either NATO or the Warsaw Pact. The United States, Canada, Japan, South Korea, Western European nations and their allies represented the " First ...
and advocates a "human right to natural genetic material". The
Database In computing, a database is an organized collection of data stored and accessed electronically. Small databases can be stored on a file system, while large databases are hosted on computer clusters or cloud storage. The design of databases sp ...
Scopus Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-l ...
calculates (as of April 2020) from 32
scientific publication : ''For a broader class of literature, see Academic publishing.'' Scientific literature comprises scholarly publications that report original empirical and theoretical work in the natural and social sciences. Within an academic field, scienti ...
s with a total of 1170 recorded
citations A citation is a reference to a source. More precisely, a citation is an abbreviated alphanumeric expression embedded in the body of an intellectual work that denotes an entry in the bibliographic references section of the work for the purpose of ...
a
h-index The ''h''-index is an author-level metric that measures both the productivity and citation impact of the publications, initially used for an individual scientist or scholar. The ''h''-index correlates with obvious success indicators such as winn ...
of 14.


COVID-19 pandemic

The
Mitteldeutscher Rundfunk Mitteldeutscher Rundfunk (MDR; ''Central German Broadcasting'') is the public broadcaster for the federal states of Thuringia, Saxony and Saxony-Anhalt in Germany. Established in January 1991, its headquarters are in Leipzig, with regional studio ...
produces the
Podcast A podcast is a program made available in digital format for download over the Internet. For example, an episodic series of digital audio or video files that a user can download to a personal device to listen to at a time of their choosing ...
'' Kekulé's Corona Compass'' on weekdays. In the context of the
COVID-19 pandemic The COVID-19 pandemic, also known as the coronavirus pandemic, is an ongoing global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The novel virus was first identif ...
, Kekulé expressed publicly on several occasions that Germany was not sufficiently prepared for a possible epidemic. While he initially thought that the virus did not pose a major threat, he later called for much stricter measures to combat the epidemic, such as interventions at German airports. With the beginning of the epidemic in Germany, Kekulé emphatically advocated his demand for two-week "corona holidays" for schools and kindergartens, which was implemented from Monday, March 16, 2020. Major events should all be cancelled and domestic travel within Germany should be reduced to a minimum. He also warned against "super horror scenarios" regarding the spread of COVID-19 in Germany. On April 11, 2020, ''
The Daily Telegraph ''The Daily Telegraph'', known online and elsewhere as ''The Telegraph'', is a national British daily broadsheet newspaper published in London by Telegraph Media Group and distributed across the United Kingdom and internationally. It was fo ...
'' quoted Kekulé as saying that the German people should "infect the young and isolate those at risk". He said that the
lockdown A lockdown is a restriction policy for people, community or a country to stay where they are, usually due to specific risks (such as COVID-19) that could possibly harm the people if they move and interact freely. The term is used for a prison ...
is "in danger of going on too long and causing more damage than the virus". He was interviewed and said that:


Publications

* "protection of the population from newly appearing Influenzaviren." Report of the protective commission, in 2006. * "highly pathogenic causes and biological agents." MiQ – high-class standards in the microbiological infektiologischen diagnostics (4 volumes), in 2008, , , , . * "bio-death at 45 minutes? – Facts and fictions to the Iraqi bioweapon programme." In: Bernd W. Kubbig (Ed.): "Source of fire Iraq." Campus, Frankfurt am Main 2003, , page 44–49.


References


External links


Kekulé in the research main entrance Saxony-Anhalt

of Alexander S. Kekulé
{{DEFAULTSORT:Kekule, Alexander S. German microbiologists German immunologists German virologists Bioethicists 1958 births Living people HIV/AIDS researchers Physicians from Munich Academic staff of the University of Halle Ludwig Maximilian University of Munich alumni German medical researchers COVID-19 pandemic in Germany