Alan Krensky is executive for development at Northwestern Medicine and vice dean for development and alumni relations at Northwestern's

Feinberg School of Medicine Northwestern University Feinberg School of Medicine is the medical school of Northwestern University and is located in the Streeterville neighborhood of Chicago, Illinois. Founded in 1859, Feinberg offers a full-time Doctor of Medicine degree p ...

. He was previously senior investigator in the Laboratory of Cellular and Molecular Biology at the

National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...

(NIH) and served as the first director of the Office of Portfolio Analysis and Strategic Initiatives (OPASI) and a deputy director of NIH. He was

Associate Dean Dean is a title employed in academic administrations such as colleges or universities for a person with significant authority over a specific academic unit, over a specific area of concern, or both. In the United States and Canada, deans are usua ...

for Children’s Health and the Shelagh Galligan

Professor Professor (commonly abbreviated as Prof.) is an academic rank at universities and other post-secondary education and research institutions in most countries. Literally, ''professor'' derives from Latin as a "person who professes". Professors ...

of Pediatrics at Stanford University.

Biography

Krensky was born in Chicago, Illinois in 1951 and attended New Trier High School (East). He received a B.A. in biology, Summa Cum Laude, and M.D. from the

University of Pennsylvania The University of Pennsylvania (also known as Penn or UPenn) is a private research university in Philadelphia. It is the fourth-oldest institution of higher education in the United States and is ranked among the highest-regarded universitie ...

. He was a

Resident (medicine) Residency or postgraduate training is specifically a stage of graduate medical education. It refers to a qualified physician (one who holds the degree of Doctor of medicine, MD, Doctor of Osteopathic Medicine, DO, MBBS, MBChB), veterinarian (Doc ...

and Fellow in Pediatrics at Children’s Hospital Boston and a

research fellow A research fellow is an academic research position at a university or a similar research institution, usually for academic staff or faculty members. A research fellow may act either as an independent investigator or under the supervision of a pr ...

at Dana Farber Cancer Institute, Boston. After one year on the faculty at Harvard and Boston Children’s Hospital, he moved to Stanford in 1984. He was on the faculty at Stanford for 23 years and developed the Children’s Health Initiative, a $500 million investment in research, education and clinical care, at Stanford and

Lucile Packard Children's Hospital Lucile Packard Children's Hospital at Stanford (LPCH) is a nationally ranked women's and children's hospital which is part of the Stanford University Health system. The hospital is located adjacent to the campus at 725 Welch Road, Palo Alto, Cal ...

Work

Krensky has published more than 280 papers and chapters in immunology and pediatrics, and holds 12 U.S. patents. He identified the human lymphocyte function-associated antigens 1-3, immunomodulatory HLA derived peptides (AllotrapTM), chemokine RANTES (

CCL5 Chemokine (C-C motif) ligand 5 (also CCL5) is a protein which in humans is encoded by the ''CCL5'' gene. The gene has been discovered in 1990 by ''in situ'' hybridisation and it is localised on 17q11.2-q12 chromosome. It is also known as RANTE ...

), proinflammatory and cytotoxic molecule granulysin ( GNLY) and the transcription factor Kruppel-like factor 13 ( KLF13). At NIH, Krensky oversaw the Roadmap for Medical Research (Biomedical Research), introducing new programs in

Epigenomics Epigenomics is the study of the complete set of epigenetic modifications on the genetic material of a cell, known as the epigenome. The field is analogous to genomics and proteomics, which are the study of the genome and proteome of a cell. Epigen ...

, Human

Microbiome A microbiome () is the community of microorganisms that can usually be found living together in any given habitat. It was defined more precisely in 1988 by Whipps ''et al.'' as "a characteristic microbial community occupying a reasonably wel ...

and Transformative RO1s. Roadmap projects are designed to rapidly respond to emerging scientific opportunities and public health needs. He led the development of the esearch, Condition, and Disease Categorization (RCDC)system, a computerized tool to permit transparent accounting of NIH funding, and a Science of Science Management effort to develop metrics for accountability in scientific progress. He co-chaired the NIH ouncil of Councils with responsibility for trans-NIH initiatives. Krensky holds numerous awards, including the American Academy of Pediatrics Award for Excellence in Pediatric Research, E. Mead Johnson Award for Research in Pediatrics, and

Novartis Novartis AG is a Swiss-American multinational pharmaceutical corporation based in Basel, Switzerland and Cambridge, Massachusetts, United States (global research).name="novartis.com">https://www.novartis.com/research-development/research-loc ...

Established Investigator Award of the

American Society of Transplantation The American Society of Transplantation (AST) is an international organization of over 4,000 transplant professionals dedicated to advancing the field of transplantation through the promotion of research, education, advocacy, organ donation, and se ...

. He served as president of the Society for Pediatric Research and secretary treasurer of the

American Society of Nephrology Founded in 1966, the American Society of Nephrology (ASN) is the world's largest professional society devoted to the study of kidney disease. Composed of over 20,000 physicians and scientists, ASN promotes expert patient care, advances medical ...

. He is a member of the

American Society for Clinical Investigation The American Society for Clinical Investigation (ASCI), established in 1908, is one of the oldest and most respected medical honor societies in the United States. Organization and purpose The ASCI is an honorary society to which more than 2,800 ph ...

and

Association of American Physicians The Association of American Physicians (AAP) is an honorary medical society founded in 1885 by the Canadian physician Sir William Osler and six other distinguished physicians of his era for "the advancement of scientific and practical medicine." ...

Publications

*Nelson PJ, Krensky AM:

Chemokines Chemokines (), or chemotactic cytokines, are a family of small cytokines or signaling proteins secreted by cells that induce directional movement of leukocytes, as well as other cell types, including endothelial and epithelial cells. In addition ...

chemokine receptors Chemokine receptors are cytokine receptors found on the surface of certain cells that interact with a type of cytokine called a chemokine. There have been 20 distinct chemokine receptors discovered in humans. Each has a rhodopsin-like 7-trans ...

, and allograft rejection. ''Immunity'' 2001; 14: 377-386. *Spada FM, Grant EP, Peters PJ, Sugita M, Melian A, Leslie DS, Lee HK, van Donselaar E, Hanson DA, Krensky AM, Majdic O, Porcelli SA, Morita CT, Brenner MB: Self recognition of

CD1 CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells. They are related to the class I MHC molecules, and are involved in the presentation of lipid antigens to T ...

by γδ T cells: implications for

innate immunity The innate, or nonspecific, immune system is one of the two main immunity strategies (the other being the adaptive immune system) in vertebrates. The innate immune system is an older evolutionary defense strategy, relatively speaking, and is the ...

. ''J. Exp. Med.'' 2000; 191: 937-948. *Stenger S, Hanson DA, Teitlebaum R, Dewan P, Niazi KR, Froelich CJ, Ganz T, Thoma-Uszynski S, Melian A, Bogdan C, Porcelli SA, Bloom BR, Krensky AM, Modlin RL: An antimicrobial activity of cytolytic T cells mediated by granulysin. ''Science'' 1998; 282: 121-125. *Pena SV, Krensky AM: Granulysin, a new human cytolytic granule associated

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...

with possible involvement in cell-mediated cytotoxicity. ''Sem. Immunol.'' 1997; 9:117-125. *Nelson EL, Li XB, Hsu FJ, Kwak LW, Levy R, Clayberger C, Krensky AM:

Tumor A neoplasm () is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists ...

specific

cytotoxic T lymphocyte A cytotoxic T cell (also known as TC, cytotoxic T lymphocyte, CTL, T-killer cell, cytolytic T cell, CD8+ T-cell or killer T cell) is a T cell, T lymphocyte (a type of white blood cell) that kills cancer cells, cells that are infected by intracel ...

response after

idiotype In immunology, an idiotype is a shared characteristic between a group of immunoglobulin or T-cell receptor (TCR) molecules based upon the antigen binding specificity and therefore structure of their variable region. The variable region of antigen ...

vaccination Vaccination is the administration of a vaccine to help the immune system develop immunity from a disease. Vaccines contain a microorganism or virus in a weakened, live or killed state, or proteins or toxins from the organism. In stimulating ...

for B cell, Non-Hodgkin’s

lymphoma Lymphoma is a group of blood and lymph tumors that develop from lymphocytes (a type of white blood cell). In current usage the name usually refers to just the cancerous versions rather than all such tumours. Signs and symptoms may include enla ...

. ''Blood.'' 1996; 88:580-589. *Pattison J, Nelson PJ, Huie P, von Luettichau I, Farshid G, Sibley RK, Krensky AM:

RANTES Chemokine (C-C motif) ligand 5 (also CCL5) is a protein which in humans is encoded by the ''CCL5'' gene. The gene has been discovered in 1990 by ''in situ'' hybridisation and it is localised on 17q11.2-q12 chromosome. It is also known as RANTES ...

chemokine Chemokines (), or chemotactic cytokines, are a family of small cytokines or signaling proteins secreted by cells that induce directional movement of leukocytes, as well as other cell types, including endothelial and epithelial cells. In additio ...

expression in cell mediated transplant rejection of the

kidney The kidneys are two reddish-brown bean-shaped organs found in vertebrates. They are located on the left and right in the retroperitoneal space, and in adult humans are about in length. They receive blood from the paired renal arteries; blo ...

. ''Lancet.'' 1994; 343: 209-211. *Krensky AM, Weiss A, Crabtree G, Davis M, Parham P: Mechanisms of disease:

T lymphocyte A T cell is a type of lymphocyte. T cells are one of the important white blood cells of the immune system and play a central role in the adaptive immune response. T cells can be distinguished from other lymphocytes by the presence of a T-cell r ...

- antigen interactions in

transplant rejection Transplant rejection occurs when transplanted tissue is rejected by the recipient's immune system, which destroys the transplanted tissue. Transplant rejection can be lessened by determining the molecular similitude between donor and recipient ...

. ''N. Engl. J. Med.'' 1990; 322: 510-517. *Salter RD, Benjamin RJ, Wesley PK, Buxton S, Garrett TPJ, Clayberger C, Krensky AM, Norment AM, Littman DR, Parham P: A binding site for the T cell co-receptor,

CD8 CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the CD8 co-receptor plays a role in T cell signaling and aiding with cytotoxic T cell-antigen int ...

, on the alpha3 domain of HLA-A2. ''Nature.'' 1990; 345: 41-46. *Salter RD, Norment AM, Chen BP, Clayberger C, Krensky AM, Littman DR, and Parham P: Polymorphism in the alpha3 domain of

HLA-A HLA-A is a group of human leukocyte antigens (HLA) that are encoded by the HLA-A locus, which is located at human chromosome 6p21.3. HLA is a major histocompatibility complex (MHC) antigen specific to humans. HLA-A is one of three major types of ...

molecules affects binding to

. ''Nature.'' 1989; 338: 345-347. *Krensky AM, Robbins E, Springer TA, and Burakoff SJ:

LFA-1 Lymphocyte function-associated antigen 1 (LFA-1) is an integrin found on lymphocytes and other leukocytes. LFA-1 plays a key role in emigration, which is the process by which leukocytes leave the bloodstream to enter the tissues. LFA-1 also mediates ...

, LFA-2, and LFA-3 antigens are involved in CTL-target conjugation. ''J. Immunol.'' 1984; 132: 2180-2182. *Krensky AM, Sanchez-Madrid F, Robbins E, Nagy J, Springer TA, Burakoff SJ: The functional significance, distribution and structure of

, LFA-2, and LFA-3: Cell surface antigens associated with the CTL-target interactions. ''J. Immunol.'' 1983; 131: 611-616. *Pober JS, Collins T, Gimbrone MA, Cotran RS, Gitlin J, Fiers W, Clayberger C, Krensky AM, Burakoff SJ, Reiss CS: Lymphocytes recognize human vascular

endothelial The endothelium is a single layer of squamous endothelial cells that line the interior surface of blood vessels and lymphatic vessels. The endothelium forms an interface between circulating blood or lymph in the lumen and the rest of the vessel ...

and dermal fibroblast Ia

antigen In immunology, an antigen (Ag) is a molecule or molecular structure or any foreign particulate matter or a pollen grain that can bind to a specific antibody or T-cell receptor. The presence of antigens in the body may trigger an immune respons ...

s induced by recombinant immune interferon. ''Nature'' 1983; 305: 726-729. *Sanchez-Madrid F, Krensky AM, Ware CF, Robbins E, Strominger JL, Burakoff SJ, Springer TA: Three distinct antigens associated with human T-lymphocyte-mediated cytolysis:

, LFA-2 (CD2), and LFA-3 (CD58). ''Proc. Natl. Acad. Sci. USA'' 1982; 79: 7489-7493.

References

{{DEFAULTSORT:Krensky, Alan M. 1951 births University of Pennsylvania alumni Harvard Medical School faculty Stanford University School of Medicine faculty American pediatricians Living people Perelman School of Medicine at the University of Pennsylvania alumni